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result sql = Late cardiotoxic effects of anthracycline chemotherapy in childhood malignancies.
Late cardiotoxic effects of anthracycline chemotherapy in childhood malignancies.char = <;code = 60
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char = ;code = 32
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result sql = OBJECTIVE : To determine the frequency of changes in left ventricular function in patients, at least 5 years after completion of anthracycline-therapy for childhood malignancy.
METHODS : Echocardiographic examination was performed on 58 patients (36 males and 22 females) with mean age of 17.5+/-4.6 years (range 9-29 years, median 17.5 years). The control group was 58 healthy age and sex matched children.
RESULTS : The age at the time of diagnosis and start of treatment ranged from 2 to 14 years with a median of 6 years. The time of follow-up was between 5 to 22 years with a median of 9 years. The cumulative dose of anthracycline was 30 to 557 mg/m2, median 128.5 mg/m2. All the patients were asymptomatic. Abnormal systolic and/or diastolic functions were found in 29 (50%) patients. We found a strong correlation between systolic and diastolic cardiac dysfunction and longer time of follow-up (P = 0.02 and p = 0.04), respectively, but not a relation to the cumulative dose, sex, and age at diagnosis.
CONCLUSION : The data showed a relatively high incidence of subclinical cardiotoxicity in long-term survivors. The significance of this subclinical cardiotoxicity on the morbidity and mortality of patients should be followed in the future.
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char = o;code = 111
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char = o;code = 111
char = x;code = 120
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char = f;code = 102
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result sql = Late cardiotoxic effects of anthracycline chemotherapy in childhood malignancies.
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char = s;code = 115
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char = a;code = 97
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char = 7;code = 55
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char = 5;code = 53
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char = e;code = 101
char = a;code = 97
char = r;code = 114
char = s;code = 115
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char = .;code = 46
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char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = o;code = 111
char = l;code = 108
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char = g;code = 103
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char = o;code = 111
char = u;code = 117
char = p;code = 112
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char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = 5;code = 53
char = 8;code = 56
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = a;code = 97
char = l;code = 108
char = t;code = 116
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char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = s;code = 115
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char = x;code = 120
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char = m;code = 109
char = a;code = 97
char = t;code = 116
char = c;code = 99
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
char = n;code = 110
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char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
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char = >;code = 62
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = t;code = 116
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char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = n;code = 110
char = o;code = 111
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char = s;code = 115
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char = d;code = 100
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = r;code = 114
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = f;code = 102
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char = o;code = 111
char = m;code = 109
char = ;code = 32
char = 2;code = 50
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = 1;code = 49
char = 4;code = 52
char = ;code = 32
char = y;code = 121
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
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char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 6;code = 54
char = ;code = 32
char = y;code = 121
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = -;code = 45
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = 5;code = 53
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = 2;code = 50
char = 2;code = 50
char = ;code = 32
char = y;code = 121
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
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char = m;code = 109
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char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 9;code = 57
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char = y;code = 121
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
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char = m;code = 109
char = u;code = 117
char = l;code = 108
char = a;code = 97
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char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = d;code = 100
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = r;code = 114
char = a;code = 97
char = c;code = 99
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char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = 3;code = 51
char = 0;code = 48
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char = t;code = 116
char = o;code = 111
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char = 5;code = 53
char = 5;code = 53
char = 7;code = 55
char = ;code = 32
char = m;code = 109
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char = /;code = 47
char = m;code = 109
char = 2;code = 50
char = ,;code = 44
char = ;code = 32
char = m;code = 109
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char = d;code = 100
char = i;code = 105
char = a;code = 97
char = n;code = 110
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char = 1;code = 49
char = 2;code = 50
char = 8;code = 56
char = .;code = 46
char = 5;code = 53
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char = m;code = 109
char = g;code = 103
char = /;code = 47
char = m;code = 109
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = a;code = 97
char = s;code = 115
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = c;code = 99
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char = o;code = 111
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char = a;code = 97
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char = s;code = 115
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char = d;code = 100
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char = a;code = 97
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char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = u;code = 117
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char = c;code = 99
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char = i;code = 105
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char = i;code = 105
char = n;code = 110
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char = 2;code = 50
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char = ;code = 32
char = (;code = 40
char = 5;code = 53
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char = %;code = 37
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char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
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char = a;code = 97
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char = s;code = 115
char = t;code = 116
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char = c;code = 99
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char = r;code = 114
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char = a;code = 97
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char = e;code = 101
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char = y;code = 121
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char = c;code = 99
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char = c;code = 99
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char = c;code = 99
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char = a;code = 97
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char = y;code = 121
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char = f;code = 102
char = u;code = 117
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char = c;code = 99
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char = i;code = 105
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char = a;code = 97
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char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = m;code = 109
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = -;code = 45
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = =;code = 61
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char = 0;code = 48
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char = 0;code = 48
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = p;code = 112
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char = =;code = 61
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char = .;code = 46
char = 0;code = 48
char = 4;code = 52
char = );code = 41
char = ,;code = 44
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char = r;code = 114
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char = s;code = 115
char = p;code = 112
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char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = y;code = 121
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char = b;code = 98
char = u;code = 117
char = t;code = 116
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char = a;code = 97
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char = >;code = 62
char = <;code = 60
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char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
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char = T;code = 84
char = h;code = 104
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char = f;code = 102
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char = y;code = 121
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char = i;code = 105
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char = s;code = 115
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char = r;code = 114
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = s;code = 115
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char = g;code = 103
char = n;code = 110
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char = c;code = 99
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char = e;code = 101
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char = o;code = 111
char = f;code = 102
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char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = s;code = 115
char = u;code = 117
char = b;code = 98
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char = i;code = 105
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char = d;code = 100
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char = o;code = 111
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char = t;code = 116
char = y;code = 121
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char = e;code = 101
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char = f;code = 102
char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = i;code = 105
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result sql = OBJECTIVE : To determine the frequency of changes in left ventricular function in patients, at least 5 years after completion of anthracycline-therapy for childhood malignancy.
METHODS : Echocardiographic examination was performed on 58 patients (36 males and 22 females) with mean age of 17.5+/-4.6 years (range 9-29 years, median 17.5 years). The control group was 58 healthy age and sex matched children.
RESULTS : The age at the time of diagnosis and start of treatment ranged from 2 to 14 years with a median of 6 years. The time of follow-up was between 5 to 22 years with a median of 9 years. The cumulative dose of anthracycline was 30 to 557 mg/m2, median 128.5 mg/m2. All the patients were asymptomatic. Abnormal systolic and/or diastolic functions were found in 29 (50%) patients. We found a strong correlation between systolic and diastolic cardiac dysfunction and longer time of follow-up (P = 0.02 and p = 0.04), respectively, but not a relation to the cumulative dose, sex, and age at diagnosis.
CONCLUSION : The data showed a relatively high incidence of subclinical cardiotoxicity in long-term survivors. The significance of this subclinical cardiotoxicity on the morbidity and mortality of patients should be followed in the future.
Publication: J Pak Med Assoc 2008 Dec ;58(12)::683-7.
Publication Date: 2008 Dec
Study Author(s): Roodpeyma, Shahla;Moussavi, Farideh;Kamali, Zinat;
Institution: Department of Pediatrics, Taleghani Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Shortcut link to this study:
Publication Date: 2008 Dec
Study Author(s): Roodpeyma, Shahla;Moussavi, Farideh;Kamali, Zinat;
Institution: Department of Pediatrics, Taleghani Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Shortcut link to this study:
OBJECTIVE : To determine the frequency of changes in left ventricular function in patients, at least 5 years after completion of anthracycline-therapy for childhood malignancy.
METHODS : Echocardiographic examination was performed on 58 patients (36 males and 22 females) with mean age of 17.5+/-4.6 years (range 9-29 years, median 17.5 years). The control group was 58 healthy age and sex matched children.
RESULTS : The age at the time of diagnosis and start of treatment ranged from 2 to 14 years with a median of 6 years. The time of follow-up was between 5 to 22 years with a median of 9 years. The cumulative dose of anthracycline was 30 to 557 mg/m2, median 128.5 mg/m2. All the patients were asymptomatic. Abnormal systolic and/or diastolic functions were found in 29 (50%) patients. We found a strong correlation between systolic and diastolic cardiac dysfunction and longer time of follow-up (P = 0.02 and p = 0.04), respectively, but not a relation to the cumulative dose, sex, and age at diagnosis.
CONCLUSION : The data showed a relatively high incidence of subclinical cardiotoxicity in long-term survivors. The significance of this subclinical cardiotoxicity on the morbidity and mortality of patients should be followed in the future.
METHODS : Echocardiographic examination was performed on 58 patients (36 males and 22 females) with mean age of 17.5+/-4.6 years (range 9-29 years, median 17.5 years). The control group was 58 healthy age and sex matched children.
RESULTS : The age at the time of diagnosis and start of treatment ranged from 2 to 14 years with a median of 6 years. The time of follow-up was between 5 to 22 years with a median of 9 years. The cumulative dose of anthracycline was 30 to 557 mg/m2, median 128.5 mg/m2. All the patients were asymptomatic. Abnormal systolic and/or diastolic functions were found in 29 (50%) patients. We found a strong correlation between systolic and diastolic cardiac dysfunction and longer time of follow-up (P = 0.02 and p = 0.04), respectively, but not a relation to the cumulative dose, sex, and age at diagnosis.
CONCLUSION : The data showed a relatively high incidence of subclinical cardiotoxicity in long-term survivors. The significance of this subclinical cardiotoxicity on the morbidity and mortality of patients should be followed in the future.
PMID: 19157322
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