char = I;code = 73
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char = i;code = 105
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = ;code = 32
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char = i;code = 105
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = r;code = 114
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char = o;code = 111
char = i;code = 105
char = l;code = 108
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = s;code = 115
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char = o;code = 111
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char = t;code = 116
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char = n;code = 110
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char = u;code = 117
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char = d;code = 100
char = ;code = 32
char = P;code = 80
char = G;code = 71
char = F;code = 70
char = 2;code = 50
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
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char = d;code = 100
char = ;code = 32
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = m;code = 109
char = y;code = 121
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = .;code = 46
result sql = Inhibitory effects of ginger oil on spontaneous and PGF2alpha-induced contraction of rat myometrium.
Inhibitory effects of ginger oil on spontaneous and PGF2alpha-induced contraction of rat myometrium.
char = S;code = 83
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
char = x;code = 120
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = o;code = 111
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char = ;code = 32
char = g;code = 103
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char = n;code = 110
char = g;code = 103
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char = r;code = 114
char = ,;code = 44
char = ;code = 32
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char = e;code = 101
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char = r;code = 114
char = h;code = 104
char = i;code = 105
char = z;code = 122
char = o;code = 111
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char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = Z;code = 90
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = i;code = 105
char = b;code = 98
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = n;code = 110
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = R;code = 82
char = o;code = 111
char = s;code = 115
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char = o;code = 111
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = Z;code = 90
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char = n;code = 110
char = g;code = 103
char = i;code = 105
char = b;code = 98
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char = r;code = 114
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = a;code = 97
char = e;code = 101
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char = ,;code = 44
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char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = b;code = 98
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char = e;code = 101
char = n;code = 110
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char = s;code = 115
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char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = s;code = 115
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char = u;code = 117
char = d;code = 100
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = i;code = 105
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char = p;code = 112
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char = a;code = 97
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = c;code = 99
char = o;code = 111
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char = o;code = 111
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = m;code = 109
char = o;code = 111
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = s;code = 115
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = H;code = 72
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char = e;code = 101
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char = r;code = 114
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char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = g;code = 103
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = o;code = 111
char = i;code = 105
char = l;code = 108
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = m;code = 109
char = o;code = 111
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = s;code = 115
char = c;code = 99
char = l;code = 108
char = e;code = 101
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char = c;code = 99
char = o;code = 111
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char = t;code = 116
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char = c;code = 99
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char = i;code = 105
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char = o;code = 111
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char = b;code = 98
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char = e;code = 101
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char = e;code = 101
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char = d;code = 100
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = m;code = 109
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
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char = w;code = 119
char = e;code = 101
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char = e;code = 101
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char = o;code = 111
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char = i;code = 105
char = n;code = 110
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char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = g;code = 103
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = i;code = 105
char = l;code = 108
char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = m;code = 109
char = y;code = 121
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
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char = o;code = 111
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char = t;code = 116
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char = a;code = 97
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char = i;code = 105
char = l;code = 108
char = i;code = 105
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char = ;code = 32
char = W;code = 87
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char = p;code = 112
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char = c;code = 99
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char = r;code = 114
char = l;code = 108
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char = x;code = 120
char = a;code = 97
char = m;code = 109
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char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = o;code = 111
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char = ;code = 32
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = c;code = 99
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char = t;code = 116
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char = s;code = 115
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char = s;code = 115
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char = y;code = 121
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char = r;code = 114
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = P;code = 80
char = G;code = 71
char = F;code = 70
char = ;code = 32
char = (;code = 40
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char = ;code = 32
char = (;code = 40
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char = a;code = 97
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char = .;code = 46
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char = g;code = 103
char = a;code = 97
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char = s;code = 115
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char = s;code = 115
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char = h;code = 104
char = ;code = 32
char = C;code = 67
char = O;code = 79
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char = (;code = 40
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char = e;code = 101
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char = s;code = 115
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result sql = Solvent extracts of ginger, the rhizome of Zingiber officinale Roscoe (Zingiberaceae), have been extensively studied for their pharmacological activities in smooth muscles. However, the effects of ginger essential oil on smooth muscle contractility have not been elucidated. The aims of the study were to investigate the effects of ginger oil on rat myometrial contractility. We particularly examined the effects on phasic contractions arising either spontaneously or with PGF (2) (alpha) stimulation. Ginger oil was obtained by hydrodistillation and its constituents analyzed using gas chromatography and mass spectrometry. Rats were humanely killed by asphyxiation with CO (2), and longitudinal uterine smooth muscles were isolated. Isometric force was measured and the effects of ginger oil studied. It was found that citral was the main constituent of ginger oil (24 %). Ginger oil inhibited spontaneous contractions with an IC (50) of 50 microL/100 mL (10 - 150 microL/100 mL). The PGF (2) (alpha)-induced contractions were also significantly reduced by ginger oil. Increases in external calcium concentration completely reversed the relaxant effects of ginger oil. This was the case for both spontaneous and PGF (2) (alpha)-induced contractions. The effects of ginger oil were indistinguishable from those of pure citral. In conclusion, ginger oil is a potent inhibitor of phasic activity in rat uterus, irrespective of how it was produced. Our data suggest that the effects are largely due to citral, and could be via inhibition of L-type Ca channels.

Publication: Planta Med. 2008 Mar ;74(4)::385-91. :doi: 10.1055/s-2008-1034323.
Publication Date: 2008 Mar
Study Author(s): Buddhakala, Nopparat;Talubmook, Chusri;Sriyotha, Poonsook;Wray, Susan;Kupittayanant, Sajeera;
Institution: Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Shortcut link to this study:
Solvent extracts of ginger, the rhizome of Zingiber officinale Roscoe (Zingiberaceae), have been extensively studied for their pharmacological activities in smooth muscles. However, the effects of ginger essential oil on smooth muscle contractility have not been elucidated. The aims of the study were to investigate the effects of ginger oil on rat myometrial contractility. We particularly examined the effects on phasic contractions arising either spontaneously or with PGF (2) (alpha) stimulation. Ginger oil was obtained by hydrodistillation and its constituents analyzed using gas chromatography and mass spectrometry. Rats were humanely killed by asphyxiation with CO (2), and longitudinal uterine smooth muscles were isolated. Isometric force was measured and the effects of ginger oil studied. It was found that citral was the main constituent of ginger oil (24 %). Ginger oil inhibited spontaneous contractions with an IC (50) of 50 microL/100 mL (10 - 150 microL/100 mL). The PGF (2) (alpha)-induced contractions were also significantly reduced by ginger oil. Increases in external calcium concentration completely reversed the relaxant effects of ginger oil. This was the case for both spontaneous and PGF (2) (alpha)-induced contractions. The effects of ginger oil were indistinguishable from those of pure citral. In conclusion, ginger oil is a potent inhibitor of phasic activity in rat uterus, irrespective of how it was produced. Our data suggest that the effects are largely due to citral, and could be via inhibition of L-type Ca channels.
PMID: 18484528

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