char = E;code = 69
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = c;code = 99
char = y;code = 121
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char = n;code = 110
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char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = t;code = 116
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char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
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char = p;code = 112
char = p;code = 112
char = l;code = 108
char = e;code = 101
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = ;code = 32
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char = o;code = 111
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = B;code = 66
char = 1;code = 49
char = 2;code = 50
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = i;code = 105
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = l;code = 108
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char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = -;code = 45
char = s;code = 115
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = l;code = 108
char = u;code = 117
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
result sql = Efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B12 in previously treated patients with non-small cell lung cancer.
Efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B12 in previously treated patients with non-small cell lung cancer.
char = <;code = 60
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char = S;code = 83
char = E;code = 69
char = ;code = 32
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char = ;code = 32
char = <;code = 60
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char = B;code = 66
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char = L;code = 76
char = C;code = 67
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char = I;code = 73
char = I;code = 73
char = I;code = 73
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char = e;code = 101
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char = ;code = 32
char = 9;code = 57
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char = 2;code = 50
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char = .;code = 46
char = 6;code = 54
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char = ,;code = 44
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char = m;code = 109
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char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = s;code = 115
char = u;code = 117
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char = i;code = 105
char = v;code = 118
char = a;code = 97
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char = t;code = 116
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char = m;code = 109
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char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = 1;code = 49
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char = .;code = 46
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char = a;code = 97
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char = 1;code = 49
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char = .;code = 46
char = 6;code = 54
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char = m;code = 109
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char = t;code = 116
char = h;code = 104
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = 1;code = 49
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char = y;code = 121
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = a;code = 97
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char = r;code = 114
char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = 5;code = 53
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char = 2;code = 50
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = 5;code = 53
char = 3;code = 51
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char = %;code = 37
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = i;code = 105
char = a;code = 97
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char = p;code = 112
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char = o;code = 111
char = g;code = 103
char = r;code = 114
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char = s;code = 115
char = s;code = 115
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char = o;code = 111
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char = f;code = 102
char = r;code = 114
char = e;code = 101
char = e;code = 101
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char = s;code = 115
char = u;code = 117
char = r;code = 114
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char = i;code = 105
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = 3;code = 51
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char = 0;code = 48
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = 2;code = 50
char = .;code = 46
char = 5;code = 53
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char = m;code = 109
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = h;code = 104
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = P;code = 80
char = 5;code = 53
char = 0;code = 48
char = 0;code = 48
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = P;code = 80
char = 1;code = 49
char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
char = ,;code = 44
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = o;code = 111
char = x;code = 120
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = i;code = 105
char = p;code = 112
char = l;code = 108
char = e;code = 101
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char = r;code = 114
char = e;code = 101
char = g;code = 103
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = p;code = 112
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char = m;code = 109
char = e;code = 101
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = x;code = 120
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = o;code = 111
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char = e;code = 101
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = t;code = 116
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = n;code = 110
char = o;code = 111
char = s;code = 115
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = D;code = 68
char = r;code = 114
char = u;code = 117
char = g;code = 103
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char = r;code = 114
char = e;code = 101
char = l;code = 108
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
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char = t;code = 116
char = y;code = 121
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char = w;code = 119
char = a;code = 97
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char = g;code = 103
char = e;code = 101
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char = r;code = 114
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
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char = t;code = 116
char = o;code = 111
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = b;code = 98
char = o;code = 111
char = t;code = 116
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char = e;code = 101
char = s;code = 115
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char = e;code = 101
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char = y;code = 121
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char = r;code = 114
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char = f;code = 102
char = i;code = 105
char = l;code = 108
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char = P;code = 80
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char = 0;code = 48
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char = o;code = 111
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char = a;code = 97
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char = l;code = 108
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char = a;code = 97
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char = i;code = 105
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char = e;code = 101
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char = t;code = 116
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char = g;code = 103
char = r;code = 114
char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = 3;code = 51
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char = o;code = 111
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char = 4;code = 52
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char = w;code = 119
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char = e;code = 101
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char = e;code = 101
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char = t;code = 116
char = r;code = 114
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char = p;code = 112
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char = i;code = 105
char = l;code = 108
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char = c;code = 99
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char = t;code = 116
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char = c;code = 99
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
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char = 2;code = 50
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char = .;code = 46
char = 2;code = 50
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char = a;code = 97
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char = a;code = 97
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char = f;code = 102
char = e;code = 101
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char = a;code = 97
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char = e;code = 101
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char = g;code = 103
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char = u;code = 117
char = t;code = 116
char = a;code = 97
char = m;code = 109
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char = n;code = 110
char = e;code = 101
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char = p;code = 112
char = y;code = 121
char = r;code = 114
char = u;code = 117
char = v;code = 118
char = i;code = 105
char = c;code = 99
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char = s;code = 115
char = a;code = 97
char = m;code = 109
char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = i;code = 105
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char = c;code = 99
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 5;code = 53
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char = 8;code = 56
char = %;code = 37
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char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = P;code = 80
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char = 0;code = 48
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char = t;code = 116
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char = p;code = 112
char = h;code = 104
char = i;code = 105
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char = a;code = 97
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char = d;code = 100
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char = 2;code = 50
char = 4;code = 52
char = .;code = 46
char = 3;code = 51
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char = ,;code = 44
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char = W;code = 87
char = B;code = 66
char = C;code = 67
char = ;code = 32
char = c;code = 99
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char = a;code = 97
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char = 1;code = 49
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char = .;code = 46
char = 0;code = 48
char = %;code = 37
char = );code = 41
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = P;code = 80
char = 1;code = 49
char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
char = .;code = 46
char = ;code = 32
char = O;code = 79
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char = e;code = 101
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char = d;code = 100
char = r;code = 114
char = u;code = 117
char = g;code = 103
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char = e;code = 101
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char = a;code = 97
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char = a;code = 97
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char = h;code = 104
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char = f;code = 102
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char = m;code = 109
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char = i;code = 105
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char = e;code = 101
char = r;code = 114
char = s;code = 115
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char = i;code = 105
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char = i;code = 105
char = a;code = 97
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char = l;code = 108
char = u;code = 117
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char = e;code = 101
char = a;code = 97
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char = e;code = 101
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char = o;code = 111
char = c;code = 99
char = c;code = 99
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char = r;code = 114
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char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = P;code = 80
char = 5;code = 53
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char = 0;code = 48
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = P;code = 80
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char = 0;code = 48
char = 0;code = 48
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = P;code = 80
char = 1;code = 49
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char = 0;code = 48
char = 0;code = 48
char = ;code = 32
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char = r;code = 114
char = e;code = 101
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char = s;code = 115
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char = m;code = 109
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char = l;code = 108
char = a;code = 97
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char = l;code = 108
char = y;code = 121
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char = a;code = 97
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = s;code = 115
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char = n;code = 110
char = g;code = 103
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = c;code = 99
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result sql = PURPOSE : The objective of this study was to evaluate the efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B(12) in pretreated Japanese patients with advanced non-small cell lung cancer (NSCLC).

EXPERIMENTAL DESIGN : Patients with an Eastern Cooperative Oncology Group performance status 0 to 2, stage III or IV, and who received previously one or two chemotherapy regimens were randomized to receive 500 mg/m(2) pemetrexed (P500) or 1,000 mg/m(2) pemetrexed (P1000) on day 1 every 3 weeks. The primary endpoint was response rate.

RESULTS : Of the 216 patients evaluable for efficacy (108 in each arm), response rates were 18.5% (90% confidence interval, 12.6-25.8%) and 14.8% (90% confidence interval, 9.5-21.6%), median survival times were 16.0 and 12.6 months, 1-year survival rates were 59.2% and 53.7%, and median progression-free survival were 3.0 and 2.5 months for the P500 and P1000, respectively. Cox multiple regression analysis indicated that pemetrexed dose was not a significant prognostic factor. Drug-related toxicity was generally tolerable for both doses; however, the safety profile of P500 showed generally milder toxicity. Main adverse drug reactions of severity grade 3 or 4 were neutrophil count decreased (20.2%) and alanine aminotransferase (glutamine pyruvic transaminase) increased (15.8%) in P500 and neutrophil count decreased (24.3%), WBC count decreased (20.7%), and lymphocyte count decreased (18.0%) in P1000. One drug-related death from interstitial lung disease occurred in the P500.

CONCLUSION : P500 and P1000 are similarly active with promising efficacy and acceptable safety outcomes in pretreated patients with NSCLC. These results support the use of P500 as a second- and third-line treatment of NSCLC.

Publication: Clin. Cancer Res. 2008 Jul 1 ;14(13)::4206-12. :doi: 10.1158/1078-0432.CCR-07-5143.
Publication Date: 2008 Jul 1
Study Author(s): Ohe, Yuichiro;Ichinose, Yukito;Nakagawa, Kazuhiko;Tamura, Tomohide;Kubota, Kaoru;Yamamoto, Nobuyuki;Adachi, Susumu;Nambu, Yoshihiro;Fujimoto, Toshio;Nishiwaki, Yutaka;Saijo, Nagahiro;Fukuoka, Masahiro;
Institution: Department of Internal Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. [email protected]
Shortcut link to this study:
PURPOSE : The objective of this study was to evaluate the efficacy and safety of two doses of pemetrexed supplemented with folic acid and vitamin B(12) in pretreated Japanese patients with advanced non-small cell lung cancer (NSCLC).

EXPERIMENTAL DESIGN : Patients with an Eastern Cooperative Oncology Group performance status 0 to 2, stage III or IV, and who received previously one or two chemotherapy regimens were randomized to receive 500 mg/m(2) pemetrexed (P500) or 1,000 mg/m(2) pemetrexed (P1000) on day 1 every 3 weeks. The primary endpoint was response rate.

RESULTS : Of the 216 patients evaluable for efficacy (108 in each arm), response rates were 18.5% (90% confidence interval, 12.6-25.8%) and 14.8% (90% confidence interval, 9.5-21.6%), median survival times were 16.0 and 12.6 months, 1-year survival rates were 59.2% and 53.7%, and median progression-free survival were 3.0 and 2.5 months for the P500 and P1000, respectively. Cox multiple regression analysis indicated that pemetrexed dose was not a significant prognostic factor. Drug-related toxicity was generally tolerable for both doses; however, the safety profile of P500 showed generally milder toxicity. Main adverse drug reactions of severity grade 3 or 4 were neutrophil count decreased (20.2%) and alanine aminotransferase (glutamine pyruvic transaminase) increased (15.8%) in P500 and neutrophil count decreased (24.3%), WBC count decreased (20.7%), and lymphocyte count decreased (18.0%) in P1000. One drug-related death from interstitial lung disease occurred in the P500.

CONCLUSION : P500 and P1000 are similarly active with promising efficacy and acceptable safety outcomes in pretreated patients with NSCLC. These results support the use of P500 as a second- and third-line treatment of NSCLC.
PMID: 18594001

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