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result sql = [The study of apoptosis induction effect of vitamin E succinate on Tca8113 human tongue cancer cells].
[The study of apoptosis induction effect of vitamin E succinate on Tca8113 human tongue cancer cells].
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char = d;code = 100
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char = t;code = 116
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = e;code = 101
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char = n;code = 110
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char = f;code = 102
char = l;code = 108
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char = o;code = 111
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char = c;code = 99
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char = y;code = 121
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char = r;code = 114
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char = r;code = 114
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char = C;code = 67
char = L;code = 76
char = U;code = 85
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char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
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char = ;code = 32
char = <;code = 60
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char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = ;code = 32
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char = n;code = 110
char = d;code = 100
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char = e;code = 101
char = ;code = 32
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char = p;code = 112
char = t;code = 116
char = o;code = 111
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char = s;code = 115
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char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = ;code = 32
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char = f;code = 102
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char = ;code = 32
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char = r;code = 114
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char = ;code = 32
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char = l;code = 108
char = a;code = 97
char = y;code = 121
char = ;code = 32
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char = n;code = 110
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
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result sql = OBJECTIVE : To investigate the apoptosis induction effect of vitamin E succinate (VES) on Tca8113 cells and its possible mechanisms.

METHODS : The proliferative activity of Tca8113 was assessed by methyl thiazolyl tetrazolium (MTT) assay. After Tca8113 cells were treated with different concentrations of VES, apoptotic rates were analyzed by flow cytometry (FCM). Fas monoclonal antibody was used for the blocking test. Fas expression was detected by immuocytochemistry(SABC assay) and FCM.

RESULTS : VES demonstrated a significant growth inhibitory effect and apoptosis induced effect on the Tca8113 cells in a dose- and time-dependent manner. Fas neutralizing antibody can block the apoptosis induced by VES. After the administration of VES, the expression of Fas protein increased and the kytoplasm staining enhanced. Proteinum quantitative analysis showed that the mean fluorescence intensity increased.

CONCLUSION : VES can induce apoptosis in human tongue cancer cells, and the up-regulation of the cell surface Fas protein may play an important role in the process.

Publication: Hua Xi Kou Qiang Yi Xue Za Zhi 2008 Aug ;26(4)::362-4.
Publication Date: 2008 Aug
Study Author(s): Cao, Xuan-ping;Wang, Shu-bin;Zhou, Hong;Wu, Hao-yang;Zhang, Yan-xi;Liu, Xue-jun;Zhang, Song-tao;
Institution: Dept. of Oral and Maxillofacial Surgery, College of Stomatology, Zhengzhou University, Zhengzhou 450052, China.
Shortcut link to this study:
OBJECTIVE : To investigate the apoptosis induction effect of vitamin E succinate (VES) on Tca8113 cells and its possible mechanisms.

METHODS : The proliferative activity of Tca8113 was assessed by methyl thiazolyl tetrazolium (MTT) assay. After Tca8113 cells were treated with different concentrations of VES, apoptotic rates were analyzed by flow cytometry (FCM). Fas monoclonal antibody was used for the blocking test. Fas expression was detected by immuocytochemistry(SABC assay) and FCM.

RESULTS : VES demonstrated a significant growth inhibitory effect and apoptosis induced effect on the Tca8113 cells in a dose- and time-dependent manner. Fas neutralizing antibody can block the apoptosis induced by VES. After the administration of VES, the expression of Fas protein increased and the kytoplasm staining enhanced. Proteinum quantitative analysis showed that the mean fluorescence intensity increased.

CONCLUSION : VES can induce apoptosis in human tongue cancer cells, and the up-regulation of the cell surface Fas protein may play an important role in the process.
PMID: 18780489

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