|
|
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result sql = Protective effects of Chlorella vulgaris on liver toxicity in cadmium-administered rats.
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char = s;code = 115
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char = f;code = 102
char = e;code = 101
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result sql = The biochemical mechanisms of Chlorella vulgaris protection against cadmium (Cd)-induced liver toxicity were investigated in male Sprague-Dawley rats (5 weeks of age, weighing 90-110 g). Forty rats were randomly divided into one control and three groups treated with 10 ppm CD: one Cd without Chlorella (Cd-0C), one Cd with 5% Chlorella (Cd-5C), and one Cd with 10% Chlorella (Cd-10C) groups. The rats had free access to water and diet for 8 weeks. Body weight gain and relative liver weight were significantly lower in the Cd-0C group than in Cd-5C and Cd-10C groups. Rats in the Cd-0C group had significantly higher hepatic concentrations of Cd and metallothioneins (MTs) than in the Cd-5C or Cd-10C group. The hepatic MT I/II mRNA was expressed in all experimental rats. MT II was more expressed in the Cd-5C and Cd-10C groups than in the Cd-0C group. Morphologically, a higher level of congestion and vacuolation was observed in the livers of the Cd-0C group compared to those of the Cd-5C and Cd-10C groups. Therefore, this study suggests that C. vulgaris has a protective effect against Cd-induced liver damage by reducing Cd accumulation and stimulating the expression of MT II in liver. However, the details of the mechanism of C. vulgaris on liver toxicity remains to be clarified by further studies.
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char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = h;code = 104
char = l;code = 108
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = a;code = 97
char = ;code = 32
char = v;code = 118
char = u;code = 117
char = l;code = 108
char = g;code = 103
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = o;code = 111
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char = c;code = 99
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char = t;code = 116
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char = d;code = 100
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Protective effects of Chlorella vulgaris on liver toxicity in cadmium-administered rats.
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char = l;code = 108
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char = C;code = 67
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char = C;code = 67
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char = l;code = 108
char = l;code = 108
char = a;code = 97
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char = (;code = 40
char = C;code = 67
char = d;code = 100
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char = 5;code = 53
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char = ,;code = 44
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char = a;code = 97
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char = ;code = 32
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char = C;code = 67
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = %;code = 37
char = ;code = 32
char = C;code = 67
char = h;code = 104
char = l;code = 108
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char = e;code = 101
char = l;code = 108
char = l;code = 108
char = a;code = 97
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char = (;code = 40
char = C;code = 67
char = d;code = 100
char = -;code = 45
char = 1;code = 49
char = 0;code = 48
char = C;code = 67
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char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
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char = h;code = 104
char = a;code = 97
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
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char = e;code = 101
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char = a;code = 97
char = c;code = 99
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = s;code = 115
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char = t;code = 116
char = o;code = 111
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char = w;code = 119
char = a;code = 97
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char = e;code = 101
char = r;code = 114
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char = a;code = 97
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char = d;code = 100
char = i;code = 105
char = e;code = 101
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = 8;code = 56
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
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char = .;code = 46
char = ;code = 32
char = B;code = 66
char = o;code = 111
char = d;code = 100
char = y;code = 121
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char = w;code = 119
char = e;code = 101
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
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char = g;code = 103
char = a;code = 97
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char = n;code = 110
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = r;code = 114
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char = l;code = 108
char = a;code = 97
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char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = w;code = 119
char = e;code = 101
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = l;code = 108
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = C;code = 67
char = d;code = 100
char = -;code = 45
char = 0;code = 48
char = C;code = 67
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = C;code = 67
char = d;code = 100
char = -;code = 45
char = 5;code = 53
char = C;code = 67
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = C;code = 67
char = d;code = 100
char = -;code = 45
char = 1;code = 49
char = 0;code = 48
char = C;code = 67
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = R;code = 82
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = C;code = 67
char = d;code = 100
char = -;code = 45
char = 0;code = 48
char = C;code = 67
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
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char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = m;code = 109
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char = t;code = 116
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = o;code = 111
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char = h;code = 104
char = i;code = 105
char = o;code = 111
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char = e;code = 101
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = ;code = 32
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char = M;code = 77
char = T;code = 84
char = s;code = 115
char = );code = 41
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = C;code = 67
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char = 5;code = 53
char = C;code = 67
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char = o;code = 111
char = r;code = 114
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char = C;code = 67
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char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = M;code = 77
char = T;code = 84
char = ;code = 32
char = I;code = 73
char = /;code = 47
char = I;code = 73
char = I;code = 73
char = ;code = 32
char = m;code = 109
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = e;code = 101
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char = s;code = 115
char = s;code = 115
char = e;code = 101
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char = a;code = 97
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char = l;code = 108
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char = e;code = 101
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char = a;code = 97
char = l;code = 108
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = T;code = 84
char = ;code = 32
char = I;code = 73
char = I;code = 73
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = m;code = 109
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
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char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = C;code = 67
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char = 5;code = 53
char = C;code = 67
char = ;code = 32
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char = d;code = 100
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char = C;code = 67
char = d;code = 100
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char = 1;code = 49
char = 0;code = 48
char = C;code = 67
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = p;code = 112
char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = C;code = 67
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char = 0;code = 48
char = C;code = 67
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = p;code = 112
char = .;code = 46
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char = M;code = 77
char = o;code = 111
char = r;code = 114
char = p;code = 112
char = h;code = 104
char = o;code = 111
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char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = l;code = 108
char = y;code = 121
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char = h;code = 104
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char = g;code = 103
char = h;code = 104
char = e;code = 101
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char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = ;code = 32
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char = f;code = 102
char = ;code = 32
char = c;code = 99
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = i;code = 105
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char = b;code = 98
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char = r;code = 114
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
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char = e;code = 101
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char = l;code = 108
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char = v;code = 118
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = e;code = 101
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char = C;code = 67
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char = 0;code = 48
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char = g;code = 103
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char = a;code = 97
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char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = f;code = 102
char = o;code = 111
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char = i;code = 105
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char = e;code = 101
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char = f;code = 102
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char = a;code = 97
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char = a;code = 97
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char = n;code = 110
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char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = r;code = 114
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char = s;code = 115
char = s;code = 115
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
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char = M;code = 77
char = T;code = 84
char = ;code = 32
char = I;code = 73
char = I;code = 73
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = H;code = 72
char = o;code = 111
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char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = m;code = 109
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result sql = The biochemical mechanisms of Chlorella vulgaris protection against cadmium (Cd)-induced liver toxicity were investigated in male Sprague-Dawley rats (5 weeks of age, weighing 90-110 g). Forty rats were randomly divided into one control and three groups treated with 10 ppm CD: one Cd without Chlorella (Cd-0C), one Cd with 5% Chlorella (Cd-5C), and one Cd with 10% Chlorella (Cd-10C) groups. The rats had free access to water and diet for 8 weeks. Body weight gain and relative liver weight were significantly lower in the Cd-0C group than in Cd-5C and Cd-10C groups. Rats in the Cd-0C group had significantly higher hepatic concentrations of Cd and metallothioneins (MTs) than in the Cd-5C or Cd-10C group. The hepatic MT I/II mRNA was expressed in all experimental rats. MT II was more expressed in the Cd-5C and Cd-10C groups than in the Cd-0C group. Morphologically, a higher level of congestion and vacuolation was observed in the livers of the Cd-0C group compared to those of the Cd-5C and Cd-10C groups. Therefore, this study suggests that C. vulgaris has a protective effect against Cd-induced liver damage by reducing Cd accumulation and stimulating the expression of MT II in liver. However, the details of the mechanism of C. vulgaris on liver toxicity remains to be clarified by further studies.
Publication: J Med Food 2008 Sep ;11(3)::479-85. :doi: 10.1089/jmf.2007.0075.
Publication Date: 2008 Sep
Study Author(s): Shim, Jae-Young;Shin, Hye-seoung;Han, Jae-Gab;Park, Hyeung-Suk;Lim, Byung-Lak;Chung, Kyung-Won;Om, Ae-Son;
Institution: Department of Food and Nutrition, College of Human Ecology, Hanyang University, Seoul, Republic of Korea.
Shortcut link to this study:
Publication Date: 2008 Sep
Study Author(s): Shim, Jae-Young;Shin, Hye-seoung;Han, Jae-Gab;Park, Hyeung-Suk;Lim, Byung-Lak;Chung, Kyung-Won;Om, Ae-Son;
Institution: Department of Food and Nutrition, College of Human Ecology, Hanyang University, Seoul, Republic of Korea.
Shortcut link to this study:
The biochemical mechanisms of Chlorella vulgaris protection against cadmium (Cd)-induced liver toxicity were investigated in male Sprague-Dawley rats (5 weeks of age, weighing 90-110 g). Forty rats were randomly divided into one control and three groups treated with 10 ppm CD: one Cd without Chlorella (Cd-0C), one Cd with 5% Chlorella (Cd-5C), and one Cd with 10% Chlorella (Cd-10C) groups. The rats had free access to water and diet for 8 weeks. Body weight gain and relative liver weight were significantly lower in the Cd-0C group than in Cd-5C and Cd-10C groups. Rats in the Cd-0C group had significantly higher hepatic concentrations of Cd and metallothioneins (MTs) than in the Cd-5C or Cd-10C group. The hepatic MT I/II mRNA was expressed in all experimental rats. MT II was more expressed in the Cd-5C and Cd-10C groups than in the Cd-0C group. Morphologically, a higher level of congestion and vacuolation was observed in the livers of the Cd-0C group compared to those of the Cd-5C and Cd-10C groups. Therefore, this study suggests that C. vulgaris has a protective effect against Cd-induced liver damage by reducing Cd accumulation and stimulating the expression of MT II in liver. However, the details of the mechanism of C. vulgaris on liver toxicity remains to be clarified by further studies.
PMID: 18800895
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