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result sql = Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model.
Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model.
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char = n;code = 110
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char = l;code = 108
char = y;code = 121
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char = l;code = 108
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char = d;code = 100
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char = c;code = 99
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char = i;code = 105
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char = s;code = 115
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char = e;code = 101
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char = i;code = 105
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char = l;code = 108
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char = s;code = 115
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char = s;code = 115
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char = k;code = 107
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char = p;code = 112
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char = a;code = 97
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char = c;code = 99
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = u;code = 117
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = o;code = 111
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char = v;code = 118
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char = n;code = 110
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char = ;code = 32
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char = t;code = 116
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char = g;code = 103
char = e;code = 101
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char = i;code = 105
char = c;code = 99
char = -;code = 45
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char = i;code = 105
char = f;code = 102
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = r;code = 114
char = u;code = 117
char = s;code = 115
char = e;code = 101
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result sql = H5N1 highly pathogenic avian influenza viruses evolved into several clades, leading to appreciably distinct antigenicities of their hemagglutinins. As such, candidate H5N1 pre-pandemic vaccines for human use should be sought. Here, to evaluate fundamental immunogenic variations between H5N1 vaccines, we prepared four inactivated H5N1 test vaccines from different phylogenetic clades (clade 1, 2.1, 2.2, and 2.3.4) in accordance with the WHO recommendation, and tested their cross-clade immunity in a mouse model by vaccination followed by challenge with heterologous virulent viruses. All H5N1 vaccines tested provided full or partial cross-clade protective immunity, except one clade 2.2-based vaccine, which did not protect mice from clade 2.3.4 virus challenge. Among the test vaccines, a clade 2.1-based vaccine possessed the broadest-spectrum cross-immunity. These results suggest that currently stockpiled pre-pandemic vaccines, especially clade 2.1-based vaccines, will likely be useful as backup vaccines in a pandemic situation, even one involving antigenic-drifted viruses.

Publication: Vaccine 2008 Nov 25 ;26(50)::6398-404. :doi: 10.1016/j.vaccine.2008.08.053.
Publication Date: 2008 Nov 25
Study Author(s): Murakami, Shin;Iwasa, Ayaka;Iwatsuki-Horimoto, Kiyoko;Ito, Mutsumi;Kiso, Maki;Kida, Hiroshi;Takada, Ayato;Nidom, Chairul A;Mai, Le Quynh;Yamada, Shinya;Imai, Hirotaka;Sakai-Tagawa, Yuko;Kawaoka, Yoshihiro;Horimoto, Taisuke;
Institution: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Shortcut link to this study:
H5N1 highly pathogenic avian influenza viruses evolved into several clades, leading to appreciably distinct antigenicities of their hemagglutinins. As such, candidate H5N1 pre-pandemic vaccines for human use should be sought. Here, to evaluate fundamental immunogenic variations between H5N1 vaccines, we prepared four inactivated H5N1 test vaccines from different phylogenetic clades (clade 1, 2.1, 2.2, and 2.3.4) in accordance with the WHO recommendation, and tested their cross-clade immunity in a mouse model by vaccination followed by challenge with heterologous virulent viruses. All H5N1 vaccines tested provided full or partial cross-clade protective immunity, except one clade 2.2-based vaccine, which did not protect mice from clade 2.3.4 virus challenge. Among the test vaccines, a clade 2.1-based vaccine possessed the broadest-spectrum cross-immunity. These results suggest that currently stockpiled pre-pandemic vaccines, especially clade 2.1-based vaccines, will likely be useful as backup vaccines in a pandemic situation, even one involving antigenic-drifted viruses.
PMID: 18804131

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