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result sql = Bilayer tablets of atorvastatin calcium and nicotinic acid: formulation and evaluation.
Bilayer tablets of atorvastatin calcium and nicotinic acid: formulation and evaluation.
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char = l;code = 108
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char = e;code = 101
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char = l;code = 108
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char = m;code = 109
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char = ;code = 32
char = c;code = 99
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char = t;code = 116
char = e;code = 101
char = n;code = 110
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char = n;code = 110
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char = ;code = 32
char = w;code = 119
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char = s;code = 115
char = ;code = 32
char = m;code = 109
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char = c;code = 99
char = h;code = 104
char = ;code = 32
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char = ;code = 32
char = f;code = 102
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char = t;code = 116
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char = v;code = 118
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = r;code = 114
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char = d;code = 100
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char = f;code = 102
char = f;code = 102
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char = r;code = 114
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = ;code = 32
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char = a;code = 97
char = l;code = 108
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char = s;code = 115
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char = y;code = 121
char = e;code = 101
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char = ;code = 32
char = t;code = 116
char = a;code = 97
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char = l;code = 108
char = e;code = 101
char = t;code = 116
char = s;code = 115
char = ;code = 32
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char = u;code = 117
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char = e;code = 101
char = ;code = 32
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char = ;code = 32
char = p;code = 112
char = o;code = 111
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char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = ;code = 32
char = d;code = 100
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char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = A;code = 65
char = T;code = 84
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = N;code = 78
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result sql = The objective of the study is to formulate bilayer tablets consisting of atorvastatin calcium (AT) as an immediate release layer and nicotinic acid (NA) as an extended release layer. The immediate release layer was prepared using super disintegrant croscarmellose sodium and extended release layer using hydroxypropylmethyl cellulose (HPMC K100M). Both the matrix and bilayer tablets were evaluated for hardness, friability, weight variation, thickness, and drug content uniformity and subjected to in vitro drug release studies. The amount of AT and NA released at different time intervals were estimated by HPLC method. The bilayer tablets showed no significant change either in physical appearance, drug content or in dissolution pattern after storing at 40 degrees C/75% relative humiding (RH) for 3 months. The release of the drug from the tablet was influenced by the polymer content and it was much evident from thermogravimetry/differential thermal analysis (TG/DTA) analysis. The results indicated that the bilayer tablets could be a potential dosage form for delivering AT and NA.

Publication: Chem. Pharm. Bull. 2008 Oct ;56(10)::1455-8.
Publication Date: 2008 Oct
Study Author(s): Nirmal, Jayabalan;Saisivam, Srinivasan;Peddanna, Chintalapati;Muralidharan, Selvadurai;Godwinkumar, Sundaram;Nagarajan, Muthuraja;
Institution: Department of Pharmaceutics, K.M. College of Pharmacy, Madurai, Tamil Nadu, India. nirmal21pharm@rediffmail.com
Shortcut link to this study:
The objective of the study is to formulate bilayer tablets consisting of atorvastatin calcium (AT) as an immediate release layer and nicotinic acid (NA) as an extended release layer. The immediate release layer was prepared using super disintegrant croscarmellose sodium and extended release layer using hydroxypropylmethyl cellulose (HPMC K100M). Both the matrix and bilayer tablets were evaluated for hardness, friability, weight variation, thickness, and drug content uniformity and subjected to in vitro drug release studies. The amount of AT and NA released at different time intervals were estimated by HPLC method. The bilayer tablets showed no significant change either in physical appearance, drug content or in dissolution pattern after storing at 40 degrees C/75% relative humiding (RH) for 3 months. The release of the drug from the tablet was influenced by the polymer content and it was much evident from thermogravimetry/differential thermal analysis (TG/DTA) analysis. The results indicated that the bilayer tablets could be a potential dosage form for delivering AT and NA.
PMID: 18827389

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