|
|
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result sql = Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.
Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.char = C;code = 67
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char = c;code = 99
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char = K;code = 75
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char = l;code = 108
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char = r;code = 114
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char = i;code = 105
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char = c;code = 99
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char = c;code = 99
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char = s;code = 115
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = F;code = 70
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
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char = ;code = 32
char = w;code = 119
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
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char = d;code = 100
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = r;code = 114
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = e;code = 101
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char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = c;code = 99
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char = t;code = 116
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char = 3;code = 51
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char = m;code = 109
char = a;code = 97
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char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = s;code = 115
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char = i;code = 105
char = t;code = 116
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = N;code = 78
char = F;code = 70
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
char = ;code = 32
char = s;code = 115
char = i;code = 105
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char = a;code = 97
char = l;code = 108
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char = n;code = 110
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char = c;code = 99
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char = c;code = 99
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char = b;code = 98
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char = ;code = 32
char = r;code = 114
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char = K;code = 75
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char = p;code = 112
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char = s;code = 115
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char = ;code = 32
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char = c;code = 99
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char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = c;code = 99
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char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Constitutive nuclear factor kappaB (NF-kappaB) activation is among the many deregulated signaling pathways that are proposed to drive pancreatic cancer cell growth and survival. Recent reports suggest that glycogen synthase kinase-3beta (GSK-3beta) plays a key role in maintaining basal NF-kappaB target gene expression and cell survival in pancreatic cancer cell lines. However, the mechanism by which GSK-3beta facilitates constitutive NF-kappaB signaling in pancreatic cancer remains unclear. In this report, we analyze the contributions of both GSK-3 isoforms (GSK-3alpha and GSK-3beta) in regulating NF-kappaB activation and cell proliferation in pancreatic cancer cell lines (Panc-1 and MiaPaCa-2). We show that GSK-3 isoforms are differentially required to maintain basal NF-kappaB DNA binding activity, transcriptional activity, and cell proliferation in Panc-1 and MiaPaCa-2 cells. Our data also indicate that IkappaB kinase (IKK) subunits are not equally required to regulate pancreatic cancer-associated NF-kappaB activity and cell growth. Importantly, we provide the first evidence that GSK-3 maintains constitutive NF-kappaB signaling in pancreatic cancer by regulating IKK activity. These data provide new insight into GSK-3-dependent NF-kappaB regulation and further establish GSK-3 and IKK as potential therapeutic targets for pancreatic cancer.
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char = e;code = 101
char = n;code = 110
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = I;code = 73
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
char = ;code = 32
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = k;code = 107
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char = p;code = 112
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
result sql = Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.
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char = p;code = 112
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char = e;code = 101
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char = S;code = 83
char = K;code = 75
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char = t;code = 116
char = a;code = 97
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char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = y;code = 121
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char = a;code = 97
char = ;code = 32
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char = r;code = 114
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char = i;code = 105
char = n;code = 110
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char = a;code = 97
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char = n;code = 110
char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = n;code = 110
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char = b;code = 98
char = a;code = 97
char = s;code = 115
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = N;code = 78
char = F;code = 70
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char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
char = ;code = 32
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
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char = g;code = 103
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char = n;code = 110
char = e;code = 101
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char = e;code = 101
char = x;code = 120
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char = r;code = 114
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char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = a;code = 97
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char = d;code = 100
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = s;code = 115
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char = r;code = 114
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = a;code = 97
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char = i;code = 105
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char = p;code = 112
char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = e;code = 101
char = c;code = 99
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char = a;code = 97
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char = i;code = 105
char = s;code = 115
char = m;code = 109
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = G;code = 71
char = S;code = 83
char = K;code = 75
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char = 3;code = 51
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char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = f;code = 102
char = a;code = 97
char = c;code = 99
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char = l;code = 108
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
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char = s;code = 115
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char = g;code = 103
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char = a;code = 97
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = i;code = 105
char = n;code = 110
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char = p;code = 112
char = a;code = 97
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char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = r;code = 114
char = e;code = 101
char = m;code = 109
char = a;code = 97
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char = n;code = 110
char = s;code = 115
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char = u;code = 117
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char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = r;code = 114
char = e;code = 101
char = p;code = 112
char = o;code = 111
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char = t;code = 116
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char = w;code = 119
char = e;code = 101
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char = a;code = 97
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char = a;code = 97
char = l;code = 108
char = y;code = 121
char = z;code = 122
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = c;code = 99
char = o;code = 111
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char = t;code = 116
char = r;code = 114
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char = b;code = 98
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = G;code = 71
char = S;code = 83
char = K;code = 75
char = -;code = 45
char = 3;code = 51
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char = i;code = 105
char = s;code = 115
char = o;code = 111
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = G;code = 71
char = S;code = 83
char = K;code = 75
char = -;code = 45
char = 3;code = 51
char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
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char = G;code = 71
char = S;code = 83
char = K;code = 75
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char = e;code = 101
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char = a;code = 97
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char = r;code = 114
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char = u;code = 117
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char = a;code = 97
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char = i;code = 105
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char = N;code = 78
char = F;code = 70
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char = k;code = 107
char = a;code = 97
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char = p;code = 112
char = a;code = 97
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char = l;code = 108
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char = 1;code = 49
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char = M;code = 77
char = i;code = 105
char = a;code = 97
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char = a;code = 97
char = C;code = 67
char = a;code = 97
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char = 2;code = 50
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char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
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char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = G;code = 71
char = S;code = 83
char = K;code = 75
char = -;code = 45
char = 3;code = 51
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char = o;code = 111
char = f;code = 102
char = o;code = 111
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char = s;code = 115
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char = f;code = 102
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char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
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char = q;code = 113
char = u;code = 117
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char = b;code = 98
char = a;code = 97
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char = a;code = 97
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char = ;code = 32
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
char = ;code = 32
char = D;code = 68
char = N;code = 78
char = A;code = 65
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char = b;code = 98
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char = n;code = 110
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char = c;code = 99
char = t;code = 116
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char = v;code = 118
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char = a;code = 97
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char = t;code = 116
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char = t;code = 116
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char = ;code = 32
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char = c;code = 99
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char = l;code = 108
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char = o;code = 111
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = i;code = 105
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char = P;code = 80
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = 1;code = 49
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char = M;code = 77
char = i;code = 105
char = a;code = 97
char = P;code = 80
char = a;code = 97
char = C;code = 67
char = a;code = 97
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char = 2;code = 50
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char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = s;code = 115
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char = a;code = 97
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char = I;code = 73
char = k;code = 107
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char = a;code = 97
char = B;code = 66
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char = n;code = 110
char = a;code = 97
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char = I;code = 73
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char = K;code = 75
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char = b;code = 98
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char = a;code = 97
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char = l;code = 108
char = y;code = 121
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char = g;code = 103
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char = a;code = 97
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char = i;code = 105
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char = c;code = 99
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char = i;code = 105
char = a;code = 97
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char = e;code = 101
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char = N;code = 78
char = F;code = 70
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
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char = a;code = 97
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char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = t;code = 116
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char = c;code = 99
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char = l;code = 108
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char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = m;code = 109
char = p;code = 112
char = o;code = 111
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char = t;code = 116
char = a;code = 97
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char = l;code = 108
char = y;code = 121
char = ,;code = 44
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char = w;code = 119
char = e;code = 101
char = ;code = 32
char = p;code = 112
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char = o;code = 111
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = r;code = 114
char = s;code = 115
char = t;code = 116
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char = e;code = 101
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = c;code = 99
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = G;code = 71
char = S;code = 83
char = K;code = 75
char = -;code = 45
char = 3;code = 51
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char = m;code = 109
char = a;code = 97
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char = a;code = 97
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char = c;code = 99
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char = i;code = 105
char = t;code = 116
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = N;code = 78
char = F;code = 70
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
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result sql = Constitutive nuclear factor kappaB (NF-kappaB) activation is among the many deregulated signaling pathways that are proposed to drive pancreatic cancer cell growth and survival. Recent reports suggest that glycogen synthase kinase-3beta (GSK-3beta) plays a key role in maintaining basal NF-kappaB target gene expression and cell survival in pancreatic cancer cell lines. However, the mechanism by which GSK-3beta facilitates constitutive NF-kappaB signaling in pancreatic cancer remains unclear. In this report, we analyze the contributions of both GSK-3 isoforms (GSK-3alpha and GSK-3beta) in regulating NF-kappaB activation and cell proliferation in pancreatic cancer cell lines (Panc-1 and MiaPaCa-2). We show that GSK-3 isoforms are differentially required to maintain basal NF-kappaB DNA binding activity, transcriptional activity, and cell proliferation in Panc-1 and MiaPaCa-2 cells. Our data also indicate that IkappaB kinase (IKK) subunits are not equally required to regulate pancreatic cancer-associated NF-kappaB activity and cell growth. Importantly, we provide the first evidence that GSK-3 maintains constitutive NF-kappaB signaling in pancreatic cancer by regulating IKK activity. These data provide new insight into GSK-3-dependent NF-kappaB regulation and further establish GSK-3 and IKK as potential therapeutic targets for pancreatic cancer.
Publication: Cancer Res. 2008 Oct 1 ;68(19)::8156-63. :doi: 10.1158/0008-5472.CAN-08-1061.
Publication Date: 2008 Oct 1
Study Author(s): Wilson, Willie;Baldwin, Albert S;
Institution: Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, USA. 27599-7295
Shortcut link to this study:
Publication Date: 2008 Oct 1
Study Author(s): Wilson, Willie;Baldwin, Albert S;
Institution: Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, USA. 27599-7295
Shortcut link to this study:
Constitutive nuclear factor kappaB (NF-kappaB) activation is among the many deregulated signaling pathways that are proposed to drive pancreatic cancer cell growth and survival. Recent reports suggest that glycogen synthase kinase-3beta (GSK-3beta) plays a key role in maintaining basal NF-kappaB target gene expression and cell survival in pancreatic cancer cell lines. However, the mechanism by which GSK-3beta facilitates constitutive NF-kappaB signaling in pancreatic cancer remains unclear. In this report, we analyze the contributions of both GSK-3 isoforms (GSK-3alpha and GSK-3beta) in regulating NF-kappaB activation and cell proliferation in pancreatic cancer cell lines (Panc-1 and MiaPaCa-2). We show that GSK-3 isoforms are differentially required to maintain basal NF-kappaB DNA binding activity, transcriptional activity, and cell proliferation in Panc-1 and MiaPaCa-2 cells. Our data also indicate that IkappaB kinase (IKK) subunits are not equally required to regulate pancreatic cancer-associated NF-kappaB activity and cell growth. Importantly, we provide the first evidence that GSK-3 maintains constitutive NF-kappaB signaling in pancreatic cancer by regulating IKK activity. These data provide new insight into GSK-3-dependent NF-kappaB regulation and further establish GSK-3 and IKK as potential therapeutic targets for pancreatic cancer.
PMID: 18829575
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