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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = o;code = 111
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char = i;code = 105
char = s;code = 115
char = m;code = 109
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = x;code = 120
char = i;code = 105
char = d;code = 100
char = a;code = 97
char = n;code = 110
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char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = s;code = 115
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char = n;code = 110
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = m;code = 109
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char = e;code = 101
char = l;code = 108
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char = y;code = 121
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = m;code = 109
char = .;code = 46
result sql = Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system.
Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system.
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char = l;code = 108
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char = e;code = 101
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char = e;code = 101
char = l;code = 108
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char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
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char = r;code = 114
char = o;code = 111
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char = d;code = 100
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = ;code = 32
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char = m;code = 109
char = a;code = 97
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char = o;code = 111
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char = ;code = 32
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char = h;code = 104
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char = a;code = 97
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char = t;code = 116
char = a;code = 97
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char = d;code = 100
char = e;code = 101
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char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = i;code = 105
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char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = t;code = 116
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char = u;code = 117
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char = o;code = 111
char = n;code = 110
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char = ;code = 32
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char = l;code = 108
char = ;code = 32
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char = h;code = 104
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char = e;code = 101
char = ;code = 32
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char = e;code = 101
char = s;code = 115
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char = t;code = 116
char = ;code = 32
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char = e;code = 101
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char = d;code = 100
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = i;code = 105
char = v;code = 118
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char = ;code = 32
char = c;code = 99
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char = m;code = 109
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char = e;code = 101
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char = v;code = 118
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char = ;code = 32
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char = s;code = 115
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char = o;code = 111
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char = e;code = 101
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result sql = The chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds was examined on DMBA-induced skin and B(a)P-induced forestomach papillomagenesis in Swiss albino mice. To the best of our knowledge, this is the first report of Fennel seeds exhibiting a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group. Further, biochemical assays showed a significant increase in the content/activities of phase I enzymes especially in the case of 6% test diet. A concomitant increase in the activities of the phase II enzymes were observed with all the doses of test diet under study. A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6% test diets of Fennel. Glyoxalase I activity and the content of reduced glutathione were significantly elevated. Expectedly, the levels of peroxidative damage along with lactate dehydrogenase activity, exhibited a significant reduction at all three doses of test diets. These findings were indicative of chemopreventive potential of Fennel against carcinogenesis.

Publication: Food Chem. Toxicol. 2008 Dec ;46(12)::3842-50.
Publication Date: 2008 Dec
Study Author(s): Singh, B;Kale, R K;
Institution: Radiation and Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, Lab No. 215, New Delhi 110067, India. [email protected]
Shortcut link to this study:
The chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds was examined on DMBA-induced skin and B(a)P-induced forestomach papillomagenesis in Swiss albino mice. To the best of our knowledge, this is the first report of Fennel seeds exhibiting a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group. Further, biochemical assays showed a significant increase in the content/activities of phase I enzymes especially in the case of 6% test diet. A concomitant increase in the activities of the phase II enzymes were observed with all the doses of test diet under study. A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6% test diets of Fennel. Glyoxalase I activity and the content of reduced glutathione were significantly elevated. Expectedly, the levels of peroxidative damage along with lactate dehydrogenase activity, exhibited a significant reduction at all three doses of test diets. These findings were indicative of chemopreventive potential of Fennel against carcinogenesis.
PMID: 18976688

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