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result sql = RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells.
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells.char = T;code = 84
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char = i;code = 105
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char = i;code = 105
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = (;code = 40
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char = o;code = 111
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char = o;code = 111
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result sql = The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. Additionally, 1,25(OH)(2)D(3) has several nongenomic effects of uncertain relevance. We show that 1,25(OH)(2)D(3) induces a transcription-independent Ca(2+) influx and activation of RhoA-Rho-associated coiled kinase (ROCK). This requires VDR and is followed by activation of the p38 mitogen-activated protein kinase (p38MAPK) and mitogen- and stress-activated kinase 1 (MSK1). As shown by the use of chemical inhibitors, dominant-negative mutants and small interfering RNA, RhoA-ROCK, and p38MAPK-MSK1 activation is necessary for the induction of CDH1/E-cadherin, CYP24, and other genes and of an adhesive phenotype by 1,25(OH)(2)D(3). RhoA-ROCK and MSK1 are also required for the inhibition of Wnt-beta-catenin pathway and cell proliferation. Thus, the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1.
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char = A;code = 65
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char = M;code = 77
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char = m;code = 109
char = e;code = 101
char = d;code = 100
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char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells.
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char = t;code = 116
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char = ;code = 32
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char = s;code = 115
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char = D;code = 68
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char = ;code = 32
char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = h;code = 104
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char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = e;code = 101
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char = b;code = 98
char = y;code = 121
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char = ,;code = 44
char = 2;code = 50
char = 5;code = 53
char = (;code = 40
char = O;code = 79
char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = D;code = 68
char = (;code = 40
char = 3;code = 51
char = );code = 41
char = .;code = 46
char = ;code = 32
char = R;code = 82
char = h;code = 104
char = o;code = 111
char = A;code = 65
char = -;code = 45
char = R;code = 82
char = O;code = 79
char = C;code = 67
char = K;code = 75
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = M;code = 77
char = S;code = 83
char = K;code = 75
char = 1;code = 49
char = ;code = 32
char = a;code = 97
char = r;code = 114
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char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = q;code = 113
char = u;code = 117
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char = r;code = 114
char = e;code = 101
char = d;code = 100
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char = f;code = 102
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char = r;code = 114
char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = W;code = 87
char = n;code = 110
char = t;code = 116
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char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = -;code = 45
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = n;code = 110
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char = p;code = 112
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char = h;code = 104
char = w;code = 119
char = a;code = 97
char = y;code = 121
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = l;code = 108
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char = r;code = 114
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char = i;code = 105
char = f;code = 102
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char = r;code = 114
char = a;code = 97
char = t;code = 116
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char = o;code = 111
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char = s;code = 115
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = c;code = 99
char = t;code = 116
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = ,;code = 44
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char = 5;code = 53
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char = O;code = 79
char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = D;code = 68
char = (;code = 40
char = 3;code = 51
char = );code = 41
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
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char = c;code = 99
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char = t;code = 116
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char = e;code = 101
char = ;code = 32
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char = u;code = 117
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char = l;code = 108
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char = s;code = 115
char = c;code = 99
char = r;code = 114
char = i;code = 105
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = R;code = 82
char = h;code = 104
char = o;code = 111
char = A;code = 65
char = -;code = 45
char = R;code = 82
char = O;code = 79
char = C;code = 67
char = K;code = 75
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = 3;code = 51
char = 8;code = 56
char = M;code = 77
char = A;code = 65
char = P;code = 80
char = K;code = 75
char = -;code = 45
char = M;code = 77
char = S;code = 83
char = K;code = 75
char = 1;code = 49
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char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. Additionally, 1,25(OH)(2)D(3) has several nongenomic effects of uncertain relevance. We show that 1,25(OH)(2)D(3) induces a transcription-independent Ca(2+) influx and activation of RhoA-Rho-associated coiled kinase (ROCK). This requires VDR and is followed by activation of the p38 mitogen-activated protein kinase (p38MAPK) and mitogen- and stress-activated kinase 1 (MSK1). As shown by the use of chemical inhibitors, dominant-negative mutants and small interfering RNA, RhoA-ROCK, and p38MAPK-MSK1 activation is necessary for the induction of CDH1/E-cadherin, CYP24, and other genes and of an adhesive phenotype by 1,25(OH)(2)D(3). RhoA-ROCK and MSK1 are also required for the inhibition of Wnt-beta-catenin pathway and cell proliferation. Thus, the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1.
Publication: J. Cell Biol. 2008 Nov 17 ;183(4)::697-710. :doi: 10.1083/jcb.200803020.
Publication Date: 2008 Nov 17
Study Author(s): Ordóñez-Morán, Paloma;Larriba, María Jesús;Pálmer, Héctor G;Valero, Ruth A;Barbáchano, Antonio;Duñach, Mireia;de Herreros, Antonio García;Villalobos, Carlos;Berciano, María Teresa;Lafarga, Miguel;Muñoz, Alberto;
Institution: Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.
Shortcut link to this study:
Publication Date: 2008 Nov 17
Study Author(s): Ordóñez-Morán, Paloma;Larriba, María Jesús;Pálmer, Héctor G;Valero, Ruth A;Barbáchano, Antonio;Duñach, Mireia;de Herreros, Antonio García;Villalobos, Carlos;Berciano, María Teresa;Lafarga, Miguel;Muñoz, Alberto;
Institution: Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.
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The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. Additionally, 1,25(OH)(2)D(3) has several nongenomic effects of uncertain relevance. We show that 1,25(OH)(2)D(3) induces a transcription-independent Ca(2+) influx and activation of RhoA-Rho-associated coiled kinase (ROCK). This requires VDR and is followed by activation of the p38 mitogen-activated protein kinase (p38MAPK) and mitogen- and stress-activated kinase 1 (MSK1). As shown by the use of chemical inhibitors, dominant-negative mutants and small interfering RNA, RhoA-ROCK, and p38MAPK-MSK1 activation is necessary for the induction of CDH1/E-cadherin, CYP24, and other genes and of an adhesive phenotype by 1,25(OH)(2)D(3). RhoA-ROCK and MSK1 are also required for the inhibition of Wnt-beta-catenin pathway and cell proliferation. Thus, the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1.
PMID: 19015318
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