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|
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result sql = Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity.
Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity.char = F;code = 70
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char = f;code = 102
char = r;code = 114
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char = m;code = 109
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char = M;code = 77
char = C;code = 67
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = s;code = 115
char = p;code = 112
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char = e;code = 101
char = n;code = 110
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char = f;code = 102
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result sql = Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently, we demonstrated that fucoidan stimulates the antigen-presenting functions of dendritic cells. In this study, we investigated the radioprotective effects of fucoidan on bone marrow cells (BMCs), which are the main cellular reservoir for the hematopoietic and immune system. To evaluate the effects of fucoidan, we assayed cell viability and immune responses. In a viability assay, fucoidan significantly increased the viability of BMCs. Based on the results of flow cytometric analysis, the increased viability of fucoidan-treated BMCs was attributed to the inhibition of radiation-induced apoptosis. Furthermore, fucoidan altered the production of immune-related cytokines from BMCs and increased the capability of BMCs to induce proliferation of allogeneic splenocytes. Taken together, our study demonstrated that fucoidan has radioprotective effects on BMCs with respect to cell viability and immunoreactivity. These results may provide valuable information, useful in the field of radiotherapy.
char = a;code = 97
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char = i;code = 105
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char = p;code = 112
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char = o;code = 111
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char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = f;code = 102
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char = n;code = 110
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = o;code = 111
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char = e;code = 101
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char = m;code = 109
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char = r;code = 114
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char = l;code = 108
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char = l;code = 108
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char = d;code = 100
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char = i;code = 105
char = m;code = 109
char = m;code = 109
char = u;code = 117
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char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = .;code = 46
result sql = Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity.
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char = ;code = 32
char = i;code = 105
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char = o;code = 111
char = n;code = 110
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char = a;code = 97
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char = l;code = 108
char = o;code = 111
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char = e;code = 101
char = n;code = 110
char = e;code = 101
char = i;code = 105
char = c;code = 99
char = ;code = 32
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char = p;code = 112
char = l;code = 108
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = c;code = 99
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char = k;code = 107
char = e;code = 101
char = n;code = 110
char = ;code = 32
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char = g;code = 103
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = u;code = 117
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char = t;code = 116
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char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = t;code = 116
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char = c;code = 99
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char = d;code = 100
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char = n;code = 110
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char = p;code = 112
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char = c;code = 99
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = v;code = 118
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char = u;code = 117
char = a;code = 97
char = b;code = 98
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char = n;code = 110
char = f;code = 102
char = o;code = 111
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char = i;code = 105
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char = e;code = 101
char = f;code = 102
char = u;code = 117
char = l;code = 108
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char = i;code = 105
char = n;code = 110
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char = f;code = 102
char = i;code = 105
char = e;code = 101
char = l;code = 108
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char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = a;code = 97
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = y;code = 121
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result sql = Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently, we demonstrated that fucoidan stimulates the antigen-presenting functions of dendritic cells. In this study, we investigated the radioprotective effects of fucoidan on bone marrow cells (BMCs), which are the main cellular reservoir for the hematopoietic and immune system. To evaluate the effects of fucoidan, we assayed cell viability and immune responses. In a viability assay, fucoidan significantly increased the viability of BMCs. Based on the results of flow cytometric analysis, the increased viability of fucoidan-treated BMCs was attributed to the inhibition of radiation-induced apoptosis. Furthermore, fucoidan altered the production of immune-related cytokines from BMCs and increased the capability of BMCs to induce proliferation of allogeneic splenocytes. Taken together, our study demonstrated that fucoidan has radioprotective effects on BMCs with respect to cell viability and immunoreactivity. These results may provide valuable information, useful in the field of radiotherapy.
Publication: J. Vet. Sci. 2008 Dec ;9(4)::359-65.
Publication Date: 2008 Dec
Study Author(s): Byon, Yun Young;Kim, Mi Hyoung;Yoo, Eun Sook;Hwang, Kyu Kye;Jee, Youngheun;Shin, Taekyun;Joo, Hong Gu;
Institution: College of Veterinary Medicine, Cheju National University, Jeju 690-756, Korea.
Shortcut link to this study:
Publication Date: 2008 Dec
Study Author(s): Byon, Yun Young;Kim, Mi Hyoung;Yoo, Eun Sook;Hwang, Kyu Kye;Jee, Youngheun;Shin, Taekyun;Joo, Hong Gu;
Institution: College of Veterinary Medicine, Cheju National University, Jeju 690-756, Korea.
Shortcut link to this study:
Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently, we demonstrated that fucoidan stimulates the antigen-presenting functions of dendritic cells. In this study, we investigated the radioprotective effects of fucoidan on bone marrow cells (BMCs), which are the main cellular reservoir for the hematopoietic and immune system. To evaluate the effects of fucoidan, we assayed cell viability and immune responses. In a viability assay, fucoidan significantly increased the viability of BMCs. Based on the results of flow cytometric analysis, the increased viability of fucoidan-treated BMCs was attributed to the inhibition of radiation-induced apoptosis. Furthermore, fucoidan altered the production of immune-related cytokines from BMCs and increased the capability of BMCs to induce proliferation of allogeneic splenocytes. Taken together, our study demonstrated that fucoidan has radioprotective effects on BMCs with respect to cell viability and immunoreactivity. These results may provide valuable information, useful in the field of radiotherapy.
PMID: 19043310
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