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char = a;code = 97
char = t;code = 116
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char = .;code = 46
result sql = [Influence of canthaxanthin on D-galactose induced osseous changes of rat].
[Influence of canthaxanthin on D-galactose induced osseous changes of rat].
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char = <;code = 60
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char = T;code = 84
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char = O;code = 79
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char = S;code = 83
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char = F;code = 70
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char = y;code = 121
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char = e;code = 101
char = k;code = 107
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char = W;code = 87
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char = t;code = 116
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char = l;code = 108
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char = s;code = 115
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char = e;code = 101
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char = m;code = 109
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char = e;code = 101
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char = W;code = 87
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char = m;code = 109
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char = a;code = 97
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char = s;code = 115
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char = e;code = 101
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char = u;code = 117
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char = d;code = 100
char = ;code = 32
char = a;code = 97
char = s;code = 115
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char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = r;code = 114
char = o;code = 111
char = l;code = 108
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = p;code = 112
char = .;code = 46
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char = e;code = 101
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char = e;code = 101
char = ;code = 32
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char = o;code = 111
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char = n;code = 110
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char = f;code = 102
char = i;code = 105
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char = f;code = 102
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char = e;code = 101
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char = i;code = 105
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = (;code = 40
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char = ;code = 32
char = <;code = 60
char = ;code = 32
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char = .;code = 46
char = 0;code = 48
char = 1;code = 49
char = );code = 41
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
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char = O;code = 79
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char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
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char = <;code = 60
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char = >;code = 62
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char = ;code = 32
char = h;code = 104
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char = g;code = 103
char = h;code = 104
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = l;code = 108
char = a;code = 97
char = c;code = 99
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char = o;code = 111
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char = n;code = 110
char = t;code = 116
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char = ;code = 32
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char = a;code = 97
char = n;code = 110
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char = c;code = 99
char = a;code = 97
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char = i;code = 105
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char = g;code = 103
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char = t;code = 116
char = h;code = 104
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char = n;code = 110
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char = ;code = 32
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char = e;code = 101
char = n;code = 110
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char = ;code = 32
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char = n;code = 110
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char = i;code = 105
char = t;code = 116
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char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = c;code = 99
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result sql = OBJECTIVE : To study the influence of canthaxanthin on D-galactose induced osseous changes of rat.

METHODS : Forty-five six-week-old Wistar male rats were randomly divided into model group, canthaxanthin group and young control group. In addition, 15 sixteen-month-old Wistar male rats were used as old control group. Model group and canthaxanthin group were given injections of D-galactose for 5 months (20 mg/kg/once per-day) to cause aging of rat. Then routine osseous parameters were tested and compared among the 4 groups.

RESULTS : Compared with young control group, the BMD, parameters of structural mechanics and biomechanics, bone calcium, manganese, magnesium and the content of hydroxyproline in the model group decreased significantly (P < 0.01), however, the content of bone phosphorus, the activity of bone and serum ALP increased significantly (P < 0.01). Those changes of the model group were the same as the old control group,but the changes in the canthaxanthin group significantly differed with the model group (P < 0.01).

CONCLUSION : The high does of D-galactose intake can cause aging and osteoporosis at the same time in rat, but canthaxanthin can prevent and inhibit D-galactose induced osseous changes.

Publication: Zhongguo Gu Shang 2008 Aug ;21(8)::613-6.
Publication Date: 2008 Aug
Study Author(s): Pei, Ling-peng;Hui, Bo-di;Dong, Fu-hui;
Institution: The Research Institution of Orthopaedics, China Academy of Chinese Medicine Science, Beijing 100700, Chinai.
Shortcut link to this study:
OBJECTIVE : To study the influence of canthaxanthin on D-galactose induced osseous changes of rat.

METHODS : Forty-five six-week-old Wistar male rats were randomly divided into model group, canthaxanthin group and young control group. In addition, 15 sixteen-month-old Wistar male rats were used as old control group. Model group and canthaxanthin group were given injections of D-galactose for 5 months (20 mg/kg/once per-day) to cause aging of rat. Then routine osseous parameters were tested and compared among the 4 groups.

RESULTS : Compared with young control group, the BMD, parameters of structural mechanics and biomechanics, bone calcium, manganese, magnesium and the content of hydroxyproline in the model group decreased significantly (P < 0.01), however, the content of bone phosphorus, the activity of bone and serum ALP increased significantly (P < 0.01). Those changes of the model group were the same as the old control group,but the changes in the canthaxanthin group significantly differed with the model group (P < 0.01).

CONCLUSION : The high does of D-galactose intake can cause aging and osteoporosis at the same time in rat, but canthaxanthin can prevent and inhibit D-galactose induced osseous changes.
PMID: 19108380

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