|
|
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char = e;code = 101
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result sql = Glutaraldehyde (GA) induces DNA-protein crosslinks (DPX), but conflicting results have been reported with regard to other genotoxic and mutagenic effects in mammalian cells in vitro. We, therefore, characterized the genotoxic and mutagenic potential of GA in V79 cells. Using the alkaline comet assay we demonstrated the induction of DPX by GA (reduction of gamma ray-induced DNA migration) at a concentration of 10 microM and above. The standard comet assay did not reveal a significant DNA strand-breaking activity of GA. Cross-linking concentrations of GA were also cytotoxic, i.e. inhibited cell growth of treated V79 cultures. Interestingly, a small but statistically significant increase in sister chromatid exchange (SCE) and micronuclei (MN) was already measured at lower concentrations (2 and 5 microM) FISH : analysis revealed that the majority of GA-induced MN was due to chromosome breaks. We also compared the genotoxic activity of GA to that of formaldehyde (FA). Similar to GA, FA-induced DPX, SCE and MN, but distinct differences exist with regard to the sensitivity of the endpoints and the relationship between genotoxicity and cytotoxicity. However, the differences in genotoxicity cannot readily explain the different carcinogenic activities of the two compounds.
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result sql = The genotoxic potential of glutaraldehyde in mammalian cells in vitro in comparison with formaldehyde.
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char = o;code = 111
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char = ;code = 32
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char = P;code = 80
char = X;code = 88
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char = y;code = 121
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char = A;code = 65
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char = d;code = 100
char = u;code = 117
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char = o;code = 111
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char = ;code = 32
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char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
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char = u;code = 117
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char = ;code = 32
char = D;code = 68
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char = m;code = 109
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char = g;code = 103
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = i;code = 105
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char = o;code = 111
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char = ;code = 32
char = 1;code = 49
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char = T;code = 84
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char = s;code = 115
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char = s;code = 115
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char = r;code = 114
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char = a;code = 97
char = l;code = 108
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char = a;code = 97
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char = s;code = 115
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = D;code = 68
char = N;code = 78
char = A;code = 65
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
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char = a;code = 97
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char = a;code = 97
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char = i;code = 105
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = G;code = 71
char = A;code = 65
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = r;code = 114
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char = s;code = 115
char = s;code = 115
char = -;code = 45
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = c;code = 99
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = G;code = 71
char = A;code = 65
char = ;code = 32
char = w;code = 119
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char = r;code = 114
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char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = c;code = 99
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char = t;code = 116
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char = t;code = 116
char = o;code = 111
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char = c;code = 99
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char = ;code = 32
char = i;code = 105
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char = b;code = 98
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = t;code = 116
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char = e;code = 101
char = a;code = 97
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char = e;code = 101
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char = c;code = 99
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char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
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char = .;code = 46
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char = I;code = 73
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char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = s;code = 115
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char = i;code = 105
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char = l;code = 108
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char = g;code = 103
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char = f;code = 102
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char = c;code = 99
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char = e;code = 101
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char = w;code = 119
char = a;code = 97
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char = <;code = 60
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char = F;code = 70
char = I;code = 73
char = S;code = 83
char = H;code = 72
char = ;code = 32
char = :;code = 58
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char = <;code = 60
char = /;code = 47
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char = e;code = 101
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char = e;code = 101
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char = G;code = 71
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char = u;code = 117
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char = e;code = 101
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char = M;code = 77
char = N;code = 78
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char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = d;code = 100
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char = c;code = 99
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char = m;code = 109
char = e;code = 101
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char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = s;code = 115
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char = W;code = 87
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char = t;code = 116
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char = a;code = 97
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char = E;code = 69
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char = M;code = 77
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char = b;code = 98
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char = t;code = 116
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char = H;code = 72
char = o;code = 111
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char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
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result sql = Glutaraldehyde (GA) induces DNA-protein crosslinks (DPX), but conflicting results have been reported with regard to other genotoxic and mutagenic effects in mammalian cells in vitro. We, therefore, characterized the genotoxic and mutagenic potential of GA in V79 cells. Using the alkaline comet assay we demonstrated the induction of DPX by GA (reduction of gamma ray-induced DNA migration) at a concentration of 10 microM and above. The standard comet assay did not reveal a significant DNA strand-breaking activity of GA. Cross-linking concentrations of GA were also cytotoxic, i.e. inhibited cell growth of treated V79 cultures. Interestingly, a small but statistically significant increase in sister chromatid exchange (SCE) and micronuclei (MN) was already measured at lower concentrations (2 and 5 microM) FISH : analysis revealed that the majority of GA-induced MN was due to chromosome breaks. We also compared the genotoxic activity of GA to that of formaldehyde (FA). Similar to GA, FA-induced DPX, SCE and MN, but distinct differences exist with regard to the sensitivity of the endpoints and the relationship between genotoxicity and cytotoxicity. However, the differences in genotoxicity cannot readily explain the different carcinogenic activities of the two compounds.
Publication: Mutat. Res. 2008 Jan 8 ;649(1-2)::146-54.
Publication Date: 2008 Jan 8
Study Author(s): Speit, Günter;Neuss, Simone;Schütz, Petra;Fröhler-Keller, Manuela;Schmid, Oliver;
Institution: Universität Ulm, Institut für Humangenetik, Ulm, Germany. [email protected]
Shortcut link to this study:
Publication Date: 2008 Jan 8
Study Author(s): Speit, Günter;Neuss, Simone;Schütz, Petra;Fröhler-Keller, Manuela;Schmid, Oliver;
Institution: Universität Ulm, Institut für Humangenetik, Ulm, Germany. [email protected]
Shortcut link to this study:
Glutaraldehyde (GA) induces DNA-protein crosslinks (DPX), but conflicting results have been reported with regard to other genotoxic and mutagenic effects in mammalian cells in vitro. We, therefore, characterized the genotoxic and mutagenic potential of GA in V79 cells. Using the alkaline comet assay we demonstrated the induction of DPX by GA (reduction of gamma ray-induced DNA migration) at a concentration of 10 microM and above. The standard comet assay did not reveal a significant DNA strand-breaking activity of GA. Cross-linking concentrations of GA were also cytotoxic, i.e. inhibited cell growth of treated V79 cultures. Interestingly, a small but statistically significant increase in sister chromatid exchange (SCE) and micronuclei (MN) was already measured at lower concentrations (2 and 5 microM) FISH : analysis revealed that the majority of GA-induced MN was due to chromosome breaks. We also compared the genotoxic activity of GA to that of formaldehyde (FA). Similar to GA, FA-induced DPX, SCE and MN, but distinct differences exist with regard to the sensitivity of the endpoints and the relationship between genotoxicity and cytotoxicity. However, the differences in genotoxicity cannot readily explain the different carcinogenic activities of the two compounds.
PMID: 18006368
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