|
|
char = S;code = 83
char = e;code = 101
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char = n;code = 110
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char = h;code = 104
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char = s;code = 115
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char = ;code = 32
char = f;code = 102
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = u;code = 117
char = r;code = 114
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char = .;code = 46
result sql = Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture.
Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture.char = O;code = 79
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char = r;code = 114
char = ;code = 32
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char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
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char = a;code = 97
char = c;code = 99
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = r;code = 114
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
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char = v;code = 118
char = a;code = 97
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char = i;code = 105
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char = s;code = 115
char = a;code = 97
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char = s;code = 115
char = ;code = 32
char = (;code = 40
char = t;code = 116
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char = ,;code = 44
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char = e;code = 101
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char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = o;code = 111
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char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = d;code = 100
char = e;code = 101
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = a;code = 97
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char = t;code = 116
char = s;code = 115
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char = m;code = 109
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char = o;code = 111
char = a;code = 97
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char = n;code = 110
char = e;code = 101
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char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = B;code = 66
char = ;code = 32
char = i;code = 105
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char = i;code = 105
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char = d;code = 100
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char = s;code = 115
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char = w;code = 119
char = i;code = 105
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char = h;code = 104
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char = f;code = 102
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char = y;code = 121
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char = e;code = 101
char = l;code = 108
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char = i;code = 105
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char = s;code = 115
char = h;code = 104
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char = f;code = 102
char = e;code = 101
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char = b;code = 98
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
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char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
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char = o;code = 111
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char = ;code = 32
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char = s;code = 115
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char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = c;code = 99
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char = c;code = 99
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = -;code = 45
char = c;code = 99
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char = o;code = 111
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = 1;code = 49
char = 2;code = 50
char = 4;code = 52
char = ,;code = 44
char = 6;code = 54
char = 5;code = 53
char = 5;code = 53
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = c;code = 99
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char = e;code = 101
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char = 3;code = 51
char = 7;code = 55
char = 3;code = 51
char = ,;code = 44
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char = 2;code = 50
char = ;code = 32
char = a;code = 97
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char = g;code = 103
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char = d;code = 100
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char = m;code = 109
char = a;code = 97
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char = a;code = 97
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char = ;code = 32
char = u;code = 117
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char = e;code = 101
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char = a;code = 97
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char = m;code = 109
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char = ,;code = 44
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char = a;code = 97
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result sql = Our aim was to study fracture risk in users of various antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, and the group of other antidepressants including monoamine oxidase B inhibitors and drugs with effect on the norepinephrine system) and its relationship with effects on inhibition of the cholinergic and serotonin transporter system. We conducted a case-control study with 124,655 fracture cases and 373,962 age- and gender-matched controls. The exposure was use of antidepressants and a number of confounders. Among the tricyclic antidepressants, amitriptyline and clomipramine were associated with a dose-dependent increase in fracture risk, while imipramine and nortriptyline were not. Amityriptyline was associated with an increased risk of fractures at low doses, while the other tricyclic antidepressants were not. Among the selective serotonin reuptake inhibitors, citalopram, fluoxetine, and sertraline were associated with a dose-dependent increase in fracture risk, while the increase was borderline statistically insignificant for paroxetine. The group of other antidepressants was not associated with fracture risk. The increase in fracture risk was significantly associated with the pharmacodynamic effect on the serotonin transporter system but not on other signaling systems. The effect of antidepressants on the risk of fractures may be linked to their effect on the serotonin transporter system. While selective serotonin receptor uptake inhibitors were associated with an increased fracture risk, tricyclic antidepressants and the group of other antidepressants were not systematically associated with fracture risk.
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char = c;code = 99
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char = u;code = 117
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char = .;code = 46
result sql = Selective serotonin reuptake inhibitors and other antidepressants and risk of fracture.
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char = s;code = 115
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char = (;code = 40
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char = s;code = 115
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char = s;code = 115
char = ,;code = 44
char = ;code = 32
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char = t;code = 116
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char = e;code = 101
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char = g;code = 103
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char = u;code = 117
char = p;code = 112
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = o;code = 111
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char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = d;code = 100
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char = t;code = 116
char = s;code = 115
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char = e;code = 101
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char = B;code = 66
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char = ;code = 32
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char = p;code = 112
char = ;code = 32
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char = t;code = 116
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char = f;code = 102
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char = i;code = 105
char = b;code = 98
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char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = c;code = 99
char = h;code = 104
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char = e;code = 101
char = r;code = 114
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char = o;code = 111
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char = n;code = 110
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char = W;code = 87
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char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = 1;code = 49
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char = 5;code = 53
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char = 3;code = 51
char = 7;code = 55
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char = t;code = 116
char = c;code = 99
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = r;code = 114
char = o;code = 111
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char = T;code = 84
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char = e;code = 101
char = ;code = 32
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char = i;code = 105
char = s;code = 115
char = k;code = 107
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char = ;code = 32
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char = ;code = 32
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
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char = f;code = 102
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char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
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char = e;code = 101
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = p;code = 112
char = o;code = 111
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char = r;code = 114
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char = y;code = 121
char = s;code = 115
char = t;code = 116
char = e;code = 101
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char = W;code = 87
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = s;code = 115
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
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char = i;code = 105
char = n;code = 110
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char = e;code = 101
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char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = u;code = 117
char = p;code = 112
char = t;code = 116
char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
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char = s;code = 115
char = ;code = 32
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char = e;code = 101
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char = i;code = 105
char = d;code = 100
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char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
char = ;code = 32
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char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
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result sql = Our aim was to study fracture risk in users of various antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, and the group of other antidepressants including monoamine oxidase B inhibitors and drugs with effect on the norepinephrine system) and its relationship with effects on inhibition of the cholinergic and serotonin transporter system. We conducted a case-control study with 124,655 fracture cases and 373,962 age- and gender-matched controls. The exposure was use of antidepressants and a number of confounders. Among the tricyclic antidepressants, amitriptyline and clomipramine were associated with a dose-dependent increase in fracture risk, while imipramine and nortriptyline were not. Amityriptyline was associated with an increased risk of fractures at low doses, while the other tricyclic antidepressants were not. Among the selective serotonin reuptake inhibitors, citalopram, fluoxetine, and sertraline were associated with a dose-dependent increase in fracture risk, while the increase was borderline statistically insignificant for paroxetine. The group of other antidepressants was not associated with fracture risk. The increase in fracture risk was significantly associated with the pharmacodynamic effect on the serotonin transporter system but not on other signaling systems. The effect of antidepressants on the risk of fractures may be linked to their effect on the serotonin transporter system. While selective serotonin receptor uptake inhibitors were associated with an increased fracture risk, tricyclic antidepressants and the group of other antidepressants were not systematically associated with fracture risk.
Publication: Calcif. Tissue Int. 2008 Feb ;82(2)::92-101. :doi: 10.1007/s00223-007-9099-9.
Publication Date: 2008 Feb
Study Author(s): Vestergaard, Peter;Rejnmark, Lars;Mosekilde, Leif;
Institution: Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK-8000 Aarhus C, Denmark. [email protected]
Shortcut link to this study:
Publication Date: 2008 Feb
Study Author(s): Vestergaard, Peter;Rejnmark, Lars;Mosekilde, Leif;
Institution: Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK-8000 Aarhus C, Denmark. [email protected]
Shortcut link to this study:
Our aim was to study fracture risk in users of various antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, and the group of other antidepressants including monoamine oxidase B inhibitors and drugs with effect on the norepinephrine system) and its relationship with effects on inhibition of the cholinergic and serotonin transporter system. We conducted a case-control study with 124,655 fracture cases and 373,962 age- and gender-matched controls. The exposure was use of antidepressants and a number of confounders. Among the tricyclic antidepressants, amitriptyline and clomipramine were associated with a dose-dependent increase in fracture risk, while imipramine and nortriptyline were not. Amityriptyline was associated with an increased risk of fractures at low doses, while the other tricyclic antidepressants were not. Among the selective serotonin reuptake inhibitors, citalopram, fluoxetine, and sertraline were associated with a dose-dependent increase in fracture risk, while the increase was borderline statistically insignificant for paroxetine. The group of other antidepressants was not associated with fracture risk. The increase in fracture risk was significantly associated with the pharmacodynamic effect on the serotonin transporter system but not on other signaling systems. The effect of antidepressants on the risk of fractures may be linked to their effect on the serotonin transporter system. While selective serotonin receptor uptake inhibitors were associated with an increased fracture risk, tricyclic antidepressants and the group of other antidepressants were not systematically associated with fracture risk.
PMID: 18219438
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The order of these related concepts is determined by a statistical analysis of the scientific literature. Highest-frequency concepts appear first.
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