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char = m;code = 109
char = e;code = 101
char = n;code = 110
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char = m;code = 109
char = e;code = 101
char = m;code = 109
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char = u;code = 117
char = l;code = 108
char = i;code = 105
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char = 5;code = 53
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char = c;code = 99
char = t;code = 116
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char = o;code = 111
char = n;code = 110
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = s;code = 115
char = u;code = 117
char = p;code = 112
char = p;code = 112
char = r;code = 114
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char = s;code = 115
char = s;code = 115
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char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
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char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = .;code = 46
result sql = Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth.
Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth.
char = T;code = 84
char = h;code = 104
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char = l;code = 108
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char = n;code = 110
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char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = f;code = 102
char = a;code = 97
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char = l;code = 108
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char = e;code = 101
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char = p;code = 112
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char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
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char = t;code = 116
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char = a;code = 97
char = t;code = 116
char = ;code = 32
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char = a;code = 97
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char = z;code = 122
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char = y;code = 121
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char = h;code = 104
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char = f;code = 102
char = a;code = 97
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char = o;code = 111
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char = k;code = 107
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char = u;code = 117
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char = q;code = 113
char = u;code = 117
char = e;code = 101
char = ;code = 32
char = C;code = 67
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char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
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char = c;code = 99
char = t;code = 116
char = u;code = 117
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char = e;code = 101
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char = ;code = 32
char = F;code = 70
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char = b;code = 98
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char = i;code = 105
char = t;code = 116
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char = O;code = 79
char = u;code = 117
char = r;code = 114
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char = e;code = 101
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char = C;code = 67
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char = h;code = 104
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char = D;code = 68
char = ,;code = 44
char = ;code = 32
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char = .;code = 46
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char = e;code = 101
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char = s;code = 115
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char = s;code = 115
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char = m;code = 109
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char = e;code = 101
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char = e;code = 101
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char = a;code = 97
char = r;code = 114
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char = w;code = 119
char = e;code = 101
char = i;code = 105
char = g;code = 103
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char = t;code = 116
char = ;code = 32
char = a;code = 97
char = s;code = 115
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char = f;code = 102
char = i;code = 105
char = b;code = 98
char = u;code = 117
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char = i;code = 105
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char = h;code = 104
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char = ;code = 32
char = f;code = 102
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char = a;code = 97
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char = m;code = 109
char = e;code = 101
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char = ;code = 32
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char = n;code = 110
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char = d;code = 100
char = ;code = 32
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char = e;code = 101
char = o;code = 111
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = b;code = 98
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char = h;code = 104
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char = i;code = 105
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char = l;code = 108
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char = l;code = 108
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char = d;code = 100
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char = i;code = 105
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char = n;code = 110
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char = o;code = 111
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char = ;code = 32
char = b;code = 98
char = a;code = 97
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char = e;code = 101
char = m;code = 109
char = e;code = 101
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char = r;code = 114
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char = ;code = 32
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char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = h;code = 104
char = ;code = 32
char = f;code = 102
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char = b;code = 98
char = u;code = 117
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char = 1;code = 49
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char = r;code = 114
char = a;code = 97
char = g;code = 103
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char = e;code = 101
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char = s;code = 115
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char = d;code = 100
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char = i;code = 105
char = b;code = 98
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char = i;code = 105
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char = c;code = 99
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char = ;code = 32
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char = c;code = 99
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char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = ;code = 32
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char = n;code = 110
char = g;code = 103
char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = i;code = 105
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char = >;code = 62
result sql = The fibulins are a family of secreted glycoproteins that are characterized by repeated epidermal-growth-factor-like domains and a unique C-terminus structure. Fibulins modulate cell morphology, growth, adhesion, and motility. Our initial basement membrane degradome screen using Cathepsin D, a tumor microenvironment-associated protease, contained fragments of fibulin-1 and full length fibulin-5. In this report, we evaluate the antiangiogenic activity of fibulin-1 and fibulin-5. Tumor studies demonstrate that both fibulin-1 and fibulin-5 suppress HT1080 tumor growth. CD31 labeling and TUNEL assay further reveal that fibulin-1 suppression of HT1080 tumor growth is associated with diminished angiogenesis and also enhanced apoptosis of endothelial cells and tumor cells. In contrast, fibulin-5 inhibits tumor angiogenesis with a minimal anti-apoptotic affect. Cathepsin D digestion of fibulin-1 produces a fragment with nearly the same molecular weight as fibulin-5, and this fragment (named Neostatin) inhibits endothelial cell proliferation. Additionally, degradation of basement membrane by cathepsin D liberates both fibulin-1 fragments and fibulin-5, which function to inhibit angiogenesis.

Publication: Exp. Biol. Med. (Maywood) 2008 Feb ;233(2)::155-62. :doi: 10.3181/0706-RM-167.
Publication Date: 2008 Feb
Study Author(s): Xie, Liang;Palmsten, Kristin;MacDonald, Brian;Kieran, Mark W;Potenta, Scott;Vong, Sylvia;Kalluri, Raghu;
Institution: Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Shortcut link to this study:
The fibulins are a family of secreted glycoproteins that are characterized by repeated epidermal-growth-factor-like domains and a unique C-terminus structure. Fibulins modulate cell morphology, growth, adhesion, and motility. Our initial basement membrane degradome screen using Cathepsin D, a tumor microenvironment-associated protease, contained fragments of fibulin-1 and full length fibulin-5. In this report, we evaluate the antiangiogenic activity of fibulin-1 and fibulin-5. Tumor studies demonstrate that both fibulin-1 and fibulin-5 suppress HT1080 tumor growth. CD31 labeling and TUNEL assay further reveal that fibulin-1 suppression of HT1080 tumor growth is associated with diminished angiogenesis and also enhanced apoptosis of endothelial cells and tumor cells. In contrast, fibulin-5 inhibits tumor angiogenesis with a minimal anti-apoptotic affect. Cathepsin D digestion of fibulin-1 produces a fragment with nearly the same molecular weight as fibulin-5, and this fragment (named Neostatin) inhibits endothelial cell proliferation. Additionally, degradation of basement membrane by cathepsin D liberates both fibulin-1 fragments and fibulin-5, which function to inhibit angiogenesis.
PMID: 18222970

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