char = B;code = 66
char = i;code = 105
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char = e;code = 101
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char = o;code = 111
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char = ;code = 32
char = d;code = 100
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char = c;code = 99
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char = l;code = 108
char = y;code = 121
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char = t;code = 116
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = s;code = 115
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char = t;code = 116
char = u;code = 117
char = b;code = 98
char = u;code = 117
char = l;code = 108
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char = n;code = 110
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char = d;code = 100
char = l;code = 108
char = e;code = 101
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char = o;code = 111
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char = a;code = 97
char = n;code = 110
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char = z;code = 122
char = a;code = 97
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char = o;code = 111
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char = i;code = 105
char = n;code = 110
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char = m;code = 109
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Bisphenol A directly targets tubulin to disrupt spindle organization in embryonic and somatic cells.
Bisphenol A directly targets tubulin to disrupt spindle organization in embryonic and somatic cells.
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char = h;code = 104
char = e;code = 101
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char = s;code = 115
char = ;code = 32
char = i;code = 105
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char = c;code = 99
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char = a;code = 97
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char = g;code = 103
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char = o;code = 111
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
char = l;code = 108
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
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char = r;code = 114
char = e;code = 101
char = p;code = 112
char = r;code = 114
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char = s;code = 115
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char = f;code = 102
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char = o;code = 111
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char = x;code = 120
char = e;code = 101
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char = o;code = 111
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char = t;code = 116
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
char = t;code = 116
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char = a;code = 97
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char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = o;code = 111
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char = e;code = 101
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char = s;code = 115
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char = h;code = 104
char = ;code = 32
char = c;code = 99
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char = ,;code = 44
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char = B;code = 66
char = i;code = 105
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char = e;code = 101
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char = o;code = 111
char = l;code = 108
char = ;code = 32
char = A;code = 65
char = ;code = 32
char = (;code = 40
char = B;code = 66
char = P;code = 80
char = A;code = 65
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = s;code = 115
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char = m;code = 109
char = e;code = 101
char = i;code = 105
char = o;code = 111
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = i;code = 105
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char = t;code = 116
char = i;code = 105
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char = g;code = 103
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char = s;code = 115
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = k;code = 107
char = i;code = 105
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char = d;code = 100
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
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char = l;code = 108
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = o;code = 111
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char = t;code = 116
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = ;code = 32
char = B;code = 66
char = i;code = 105
char = s;code = 115
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = o;code = 111
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char = ;code = 32
char = A;code = 65
char = ;code = 32
char = m;code = 109
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char = g;code = 103
char = h;code = 104
char = t;code = 116
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = r;code = 114
char = u;code = 117
char = p;code = 112
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
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char = a;code = 97
char = l;code = 108
char = y;code = 121
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char = i;code = 105
char = s;code = 115
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = r;code = 114
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char = e;code = 101
char = d;code = 100
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char = o;code = 111
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char = t;code = 116
char = ;code = 32
char = u;code = 117
char = s;code = 115
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = ;code = 32
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = h;code = 104
char = i;code = 105
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char = e;code = 101
char = g;code = 103
char = g;code = 103
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char = h;code = 104
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char = s;code = 115
char = e;code = 101
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char = e;code = 101
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char = l;code = 108
char = y;code = 121
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char = e;code = 101
char = m;code = 109
char = b;code = 98
char = r;code = 114
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char = i;code = 105
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char = i;code = 105
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char = i;code = 105
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char = .;code = 46
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char = L;code = 76
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char = o;code = 111
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char = e;code = 101
char = d;code = 100
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char = B;code = 66
char = P;code = 80
char = A;code = 65
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char = f;code = 102
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char = e;code = 101
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char = l;code = 108
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char = d;code = 100
char = e;code = 101
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char = t;code = 116
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char = m;code = 109
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char = n;code = 110
char = n;code = 110
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char = r;code = 114
char = .;code = 46
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char = u;code = 117
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char = e;code = 101
char = l;code = 108
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char = B;code = 66
char = P;code = 80
char = A;code = 65
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result sql = There is increasing concern that animal and human reproduction may be adversely affected by exposure to xenoestrogens that activate estrogen receptors. There is evidence that one such compound, Bisphenol A (BPA), also induces meiotic and mitotic aneuploidy, suggesting that these kinds of molecules may also have effects on cell division. In an effort to understand how Bisphenol A might disrupt cell division, a phenotypic analysis was carried out using sea urchin eggs, whose early embryonic divisions are independent of zygotic transcription. Fertilized Lytechinus pictus eggs exposed to BPA formed multipolar spindles resulting in failed cytokinesis in a dose-dependent, transcriptionally independent manner. By use of novel biotinylated BPA affinity probes to fractionate cell-free extracts, tubulin was identified as a candidate binding protein by mass spectrometry, and BPA promoted microtubule polymerization and centrosome-based microtubule nucleation in vitro but did not appear to display microtubule-stabilizing activity. Treatment of mammalian cells demonstrated that BPA as well as a series of Bisphenol A derivatives induced ectopic spindle pole formation in the absence of centrosome overduplication. Together, these results suggest a novel mechanism by which Bisphenol A affects the nucleation of microtubules, disrupting the tight spatial control associated with normal chromosome segregation, resulting in aneuploidy.

Publication: ACS Chem. Biol. 2008 Mar 20 ;3(3)::167-79. :doi: 10.1021/cb700210u.
Publication Date: 2008 Mar 20
Study Author(s): George, Olivia;Bryant, Bj K;Chinnasamy, Ramesh;Corona, Cesear;Arterburn, Jeffrey B;Shuster, Charles B;
Institution: Department of Biology, New Mexico State University, Las Cruces, New Mexico 88003, USA.
Shortcut link to this study:
There is increasing concern that animal and human reproduction may be adversely affected by exposure to xenoestrogens that activate estrogen receptors. There is evidence that one such compound, Bisphenol A (BPA), also induces meiotic and mitotic aneuploidy, suggesting that these kinds of molecules may also have effects on cell division. In an effort to understand how Bisphenol A might disrupt cell division, a phenotypic analysis was carried out using sea urchin eggs, whose early embryonic divisions are independent of zygotic transcription. Fertilized Lytechinus pictus eggs exposed to BPA formed multipolar spindles resulting in failed cytokinesis in a dose-dependent, transcriptionally independent manner. By use of novel biotinylated BPA affinity probes to fractionate cell-free extracts, tubulin was identified as a candidate binding protein by mass spectrometry, and BPA promoted microtubule polymerization and centrosome-based microtubule nucleation in vitro but did not appear to display microtubule-stabilizing activity. Treatment of mammalian cells demonstrated that BPA as well as a series of Bisphenol A derivatives induced ectopic spindle pole formation in the absence of centrosome overduplication. Together, these results suggest a novel mechanism by which Bisphenol A affects the nucleation of microtubules, disrupting the tight spatial control associated with normal chromosome segregation, resulting in aneuploidy.
PMID: 18225860

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