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result sql = Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling.
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result sql = The synthesis and in vitro biological evaluation (JEG-3 cells) of a series of novel and potent aromatase inhibitors, prepared by microwave-enhanced Suzuki cross-coupling methodology, are reported. These compounds possess a biphenyl template incorporated with the haem-ligating triazolylmethyl moiety, either on its own or in combination with other substituent(s) at various positions on the phenyl rings. The most potent aromatase inhibitor reported herein has an IC(50) value of 0.12 nM, although seven of its congeners are also highly potent (IC(50)
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result sql = Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling.
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char = t;code = 116
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char = ;code = 32
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = S;code = 83
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = 4;code = 52
char = 7;code = 55
char = 8;code = 56
char = .;code = 46
char = ;code = 32
char = F;code = 70
char = u;code = 117
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char = t;code = 116
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char = e;code = 101
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char = ;code = 32
char = f;code = 102
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char = ;code = 32
char = t;code = 116
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char = m;code = 109
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char = m;code = 109
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char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
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char = a;code = 97
char = r;code = 114
char = r;code = 114
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char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = i;code = 105
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = l;code = 108
char = e;code = 101
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char = e;code = 101
char = l;code = 108
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = b;code = 98
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = .;code = 46
char = <;code = 60
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char = /;code = 47
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result sql = The synthesis and in vitro biological evaluation (JEG-3 cells) of a series of novel and potent aromatase inhibitors, prepared by microwave-enhanced Suzuki cross-coupling methodology, are reported. These compounds possess a biphenyl template incorporated with the haem-ligating triazolylmethyl moiety, either on its own or in combination with other substituent(s) at various positions on the phenyl rings. The most potent aromatase inhibitor reported herein has an IC(50) value of 0.12 nM, although seven of its congeners are also highly potent (IC(50)
Publication: ChemMedChem 2008 Apr ;3(4)::603-18. :doi: 10.1002/cmdc.200700266.
Publication Date: 2008 Apr
Study Author(s): Jackson, Toby;Woo, L W Lawrence;Trusselle, Melanie N;Purohit, Atul;Reed, Michael J;Potter, Barry V L;
Institution: Medicinal Chemistry, Department of Pharmacy and Pharmacology, and Sterix Ltd. University of Bath, Claverton Down, UK.
Shortcut link to this study:
Publication Date: 2008 Apr
Study Author(s): Jackson, Toby;Woo, L W Lawrence;Trusselle, Melanie N;Purohit, Atul;Reed, Michael J;Potter, Barry V L;
Institution: Medicinal Chemistry, Department of Pharmacy and Pharmacology, and Sterix Ltd. University of Bath, Claverton Down, UK.
Shortcut link to this study:
The synthesis and in vitro biological evaluation (JEG-3 cells) of a series of novel and potent aromatase inhibitors, prepared by microwave-enhanced Suzuki cross-coupling methodology, are reported. These compounds possess a biphenyl template incorporated with the haem-ligating triazolylmethyl moiety, either on its own or in combination with other substituent(s) at various positions on the phenyl rings. The most potent aromatase inhibitor reported herein has an IC(50) value of 0.12 nM, although seven of its congeners are also highly potent (IC(50)
PMID: 18236493
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