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char = s;code = 115
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char = e;code = 101
char = .;code = 46
result sql = Antioxidant effects of vitamins C and E, multivitamin-mineral complex and flavonoids in a model of retinal oxidative stress: the ApoE-deficient mouse.
Antioxidant effects of vitamins C and E, multivitamin-mineral complex and flavonoids in a model of retinal oxidative stress: the ApoE-deficient mouse.
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char = s;code = 115
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char = r;code = 114
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char = e;code = 101
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char = t;code = 116
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char = t;code = 116
char = r;code = 114
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char = c;code = 99
char = t;code = 116
char = u;code = 117
char = r;code = 114
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char = .;code = 46
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char = A;code = 65
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char = m;code = 109
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char = a;code = 97
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char = ;code = 32
char = s;code = 115
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char = g;code = 103
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char = f;code = 102
char = i;code = 105
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char = r;code = 114
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = v;code = 118
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char = t;code = 116
char = r;code = 114
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char = s;code = 115
char = s;code = 115
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char = p;code = 112
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = r;code = 114
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char = t;code = 116
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char = n;code = 110
char = a;code = 97
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = a;code = 97
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char = m;code = 109
char = e;code = 101
char = n;code = 110
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = N;code = 78
char = O;code = 79
char = x;code = 120
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char = c;code = 99
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char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = W;code = 87
char = T;code = 84
char = -;code = 45
char = C;code = 67
char = o;code = 111
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = e;code = 101
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char = ;code = 32
char = R;code = 82
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = T;code = 84
char = B;code = 66
char = A;code = 65
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char = S;code = 83
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = A;code = 65
char = E;code = 69
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char = C;code = 67
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = A;code = 65
char = E;code = 69
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char = C;code = 67
char = E;code = 69
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
char = l;code = 108
char = s;code = 115
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = A;code = 65
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char = -;code = 45
char = C;code = 67
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = p;code = 112
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char = (;code = 40
char = P;code = 80
char = <;code = 60
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char = 0;code = 48
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char = a;code = 97
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char = d;code = 100
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char = P;code = 80
char = <;code = 60
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char = .;code = 46
char = 0;code = 48
char = 1;code = 49
char = ,;code = 44
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char = .;code = 46
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char = O;code = 79
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char = l;code = 108
char = y;code = 121
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char = A;code = 65
char = E;code = 69
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char = t;code = 116
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char = t;code = 116
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char = .;code = 46
char = 0;code = 48
char = 1;code = 49
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char = ;code = 32
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char = e;code = 101
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char = e;code = 101
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char = N;code = 78
char = O;code = 79
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char = ;code = 32
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char = o;code = 111
char = r;code = 114
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char = a;code = 97
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char = A;code = 65
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char = r;code = 114
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char = u;code = 117
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char = a;code = 97
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char = h;code = 104
char = e;code = 101
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char = A;code = 65
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char = C;code = 67
char = E;code = 69
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = A;code = 65
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char = M;code = 77
char = C;code = 67
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
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char = .;code = 46
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char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = i;code = 105
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char = e;code = 101
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char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = ;code = 32
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char = e;code = 101
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char = A;code = 65
char = E;code = 69
char = -;code = 45
char = C;code = 67
char = D;code = 68
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = A;code = 65
char = E;code = 69
char = -;code = 45
char = C;code = 67
char = C;code = 67
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = W;code = 87
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char = C;code = 67
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char = a;code = 97
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char = a;code = 97
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char = a;code = 97
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char = s;code = 115
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char = u;code = 117
char = r;code = 114
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char = m;code = 109
char = o;code = 111
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char = e;code = 101
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char = o;code = 111
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char = ;code = 32
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char = y;code = 121
char = p;code = 112
char = e;code = 101
char = r;code = 114
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char = s;code = 115
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char = a;code = 97
char = .;code = 46
char = <;code = 60
char = b;code = 98
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result sql = The aim of the current study was to investigate the biochemical changes in the plasma and retina of apolipoprotein E deficient (apoE-/-) mice supplemented with various antioxidants. Ten wild type (WT-Con, C57BL/6) and 10 apoE-/- (AE-Con) mice received drinking water. Another 40 apoE-/- animals were divided into four groups of 10 mice each and received either chromocarbe diethylamine (AE-CD, 50mg/kg), cyaninosides chloride (AE-CC, 50mg/kg), multivitamin complex (AE-MC, 50mg/kg), or vitamins C and E (AE-CE, 100mg/kg and 200IU/kg). Cholesterol, triglycerides, and lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) were measured in plasma, and TBARS and nitric oxide metabolites (NOx) concentration were determined in retinal homogenates. Transmission electron microscopy was performed to examine the retinal ultrastructure. AE-Con mice had significantly (P<0.05) increased oxidative stress in the plasma and retina with augmented production of retinal NOx compared with WT-Con mice. Retinal TBARS decreased in the AE-MC and AE-CE animals compared with the AE-Con group (P<0.05 and P<0.01, respectively). Only AE-CE treatment significantly (P<0.01) lowered retinal NOx. Morphologic retinal changes in the AE-Con group decreased in the AE-CE and AE-MC groups. There were no significant changes in the biochemical and structural parameters in the AE-CD and AE-CC groups. AE-Con mice had increased systemic and retinal oxidative stress compared with WT-Con animals. Vitamins C and E and the multivitamin-mineral complex reduced oxidative stress and ultrastructural retinal changes in this murine model of hypercholesterolemia.

Publication: Exp. Eye Res. 2008 Mar ;86(3)::470-9. :doi: 10.1016/j.exer.2007.11.020.
Publication Date: 2008 Mar
Study Author(s): Sádaba, Luis M;Fernández-Robredo, Patricia;Rodríguez, José Antonio;García-Layana, Alfredo;
Institution: Department of Ophthalmology, School of Medicine, University of Navarra, Pamplona, Spain.
Shortcut link to this study:
The aim of the current study was to investigate the biochemical changes in the plasma and retina of apolipoprotein E deficient (apoE-/-) mice supplemented with various antioxidants. Ten wild type (WT-Con, C57BL/6) and 10 apoE-/- (AE-Con) mice received drinking water. Another 40 apoE-/- animals were divided into four groups of 10 mice each and received either chromocarbe diethylamine (AE-CD, 50mg/kg), cyaninosides chloride (AE-CC, 50mg/kg), multivitamin complex (AE-MC, 50mg/kg), or vitamins C and E (AE-CE, 100mg/kg and 200IU/kg). Cholesterol, triglycerides, and lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) were measured in plasma, and TBARS and nitric oxide metabolites (NOx) concentration were determined in retinal homogenates. Transmission electron microscopy was performed to examine the retinal ultrastructure. AE-Con mice had significantly (P<0.05) increased oxidative stress in the plasma and retina with augmented production of retinal NOx compared with WT-Con mice. Retinal TBARS decreased in the AE-MC and AE-CE animals compared with the AE-Con group (P<0.05 and P<0.01, respectively). Only AE-CE treatment significantly (P<0.01) lowered retinal NOx. Morphologic retinal changes in the AE-Con group decreased in the AE-CE and AE-MC groups. There were no significant changes in the biochemical and structural parameters in the AE-CD and AE-CC groups. AE-Con mice had increased systemic and retinal oxidative stress compared with WT-Con animals. Vitamins C and E and the multivitamin-mineral complex reduced oxidative stress and ultrastructural retinal changes in this murine model of hypercholesterolemia.
PMID: 18243175

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