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char = h;code = 104
char = a;code = 97
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = c;code = 99
char = o;code = 111
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = v;code = 118
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = z;code = 122
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = b;code = 98
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = -;code = 45
char = a;code = 97
char = d;code = 100
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = ;code = 32
char = f;code = 102
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Pharmacokinetics and tolerability of voriconazole and a combination oral contraceptive co-administered in healthy female subjects.

Pharmacokinetics and tolerability of voriconazole and a combination oral contraceptive co-administered in healthy female subjects.

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char = W;code = 87
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char = T;code = 84
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char = I;code = 73
char = S;code = 83
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char = L;code = 76
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char = W;code = 87
char = N;code = 78
char = ;code = 32
char = A;code = 65
char = B;code = 66
char = O;code = 79
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char = T;code = 84
char = ;code = 32
char = T;code = 84
char = H;code = 72
char = I;code = 73
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char = S;code = 83
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char = ;code = 32
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char = ;code = 32
char = b;code = 98
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char = u;code = 117
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char = ;code = 32
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char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = d;code = 100
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
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char = i;code = 105
char = t;code = 116
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char = ;code = 32
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char = f;code = 102
char = ;code = 32
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char = Y;code = 89
char = P;code = 80
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char = C;code = 67
char = 1;code = 49
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
char = C;code = 67
char = Y;code = 89
char = P;code = 80
char = 3;code = 51
char = A;code = 65
char = 4;code = 52
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = z;code = 122
char = y;code = 121
char = m;code = 109
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = *;code = 42
char = ;code = 32
char = E;code = 69
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = n;code = 110
char = y;code = 121
char = l;code = 108
char = ;code = 32
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char = e;code = 101
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = h;code = 104
char = i;code = 105
char = n;code = 110
char = d;code = 100
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char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ,;code = 44
char = ;code = 32
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char = m;code = 109
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = b;code = 98
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char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
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char = c;code = 99
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char = e;code = 101
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char = O;code = 79
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char = u;code = 117
char = m;code = 109
char = ;code = 32
char = 1;code = 49
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char = 5;code = 53
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char = o;code = 111
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char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
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char = P;code = 80
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char = 1;code = 49
char = 9;code = 57
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char = ;code = 32
char = C;code = 67
char = Y;code = 89
char = P;code = 80
char = 3;code = 51
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char = 4;code = 52
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = z;code = 122
char = y;code = 121
char = m;code = 109
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = *;code = 42
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char = ;code = 32
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char = m;code = 109
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char = i;code = 105
char = s;code = 115
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = r;code = 114
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = z;code = 122
char = o;code = 111
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char = e;code = 101
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char = d;code = 100
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char = O;code = 79
char = r;code = 114
char = t;code = 116
char = h;code = 104
char = o;code = 111
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char = N;code = 78
char = o;code = 111
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char = u;code = 117
char = m;code = 109
char = ;code = 32
char = 1;code = 49
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char = 5;code = 53
char = ;code = 32
char = c;code = 99
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char = d;code = 100
char = ;code = 32
char = p;code = 112
char = o;code = 111
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char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = l;code = 108
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char = i;code = 105
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char = <;code = 60
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char = n;code = 110
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char = o;code = 111
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = r;code = 114
char = a;code = 97
char = c;code = 99
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char = d;code = 100
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char = i;code = 105
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char = i;code = 105
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char = e;code = 101
char = d;code = 100
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char = s;code = 115
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char = u;code = 117
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
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char = l;code = 108
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = r;code = 114
char = u;code = 117
char = g;code = 103
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = c;code = 99
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char = -;code = 45
char = a;code = 97
char = d;code = 100
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = s;code = 115
char = a;code = 97
char = f;code = 102
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = *;code = 42
char = ;code = 32
char = I;code = 73
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = o;code = 111
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char = m;code = 109
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char = d;code = 100
char = e;code = 101
char = d;code = 100
char = ,;code = 44
char = ;code = 32
char = h;code = 104
char = o;code = 111
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char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = -;code = 45
char = a;code = 97
char = d;code = 100
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = v;code = 118
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = z;code = 122
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = m;code = 109
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char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = A;code = 65
char = I;code = 73
char = M;code = 77
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = o;code = 111
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = w;code = 119
char = o;code = 111
char = -;code = 45
char = w;code = 119
char = a;code = 97
char = y;code = 121
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char = p;code = 112
char = h;code = 104
char = a;code = 97
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = c;code = 99
char = o;code = 111
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char = n;code = 110
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = i;code = 105
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char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = t;code = 116
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char = o;code = 111
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char = b;code = 98
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char = t;code = 116
char = w;code = 119
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char = e;code = 101
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char = v;code = 118
char = o;code = 111
char = r;code = 114
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char = o;code = 111
char = n;code = 110
char = a;code = 97
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = O;code = 79
char = r;code = 114
char = t;code = 116
char = h;code = 104
char = o;code = 111
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char = N;code = 78
char = o;code = 111
char = v;code = 118
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = 1;code = 49
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char = a;code = 97
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char = ;code = 32
char = o;code = 111
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
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char = t;code = 116
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char = i;code = 105
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char = d;code = 100
char = r;code = 114
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char = n;code = 110
char = e;code = 101
char = ;code = 32
char = 1;code = 49
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char = m;code = 109
char = g;code = 103
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = e;code = 101
char = t;code = 116
char = h;code = 104
char = i;code = 105
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char = y;code = 121
char = l;code = 108
char = ;code = 32
char = o;code = 111
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char = s;code = 115
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char = r;code = 114
char = a;code = 97
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = 3;code = 51
char = 5;code = 53
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = -;code = 45
char = l;code = 108
char = a;code = 97
char = b;code = 98
char = e;code = 101
char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = -;code = 45
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = x;code = 120
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char = d;code = 100
char = -;code = 45
char = s;code = 115
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = 1;code = 49
char = 6;code = 54
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = h;code = 104
char = y;code = 121
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char = f;code = 102
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = v;code = 118
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = z;code = 122
char = o;code = 111
char = l;code = 108
char = e;code = 101
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char = (;code = 40
char = 4;code = 52
char = 0;code = 48
char = 0;code = 48
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char = g;code = 103
char = ;code = 32
char = q;code = 113
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char = d;code = 100
char = a;code = 97
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char = 1;code = 49
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char = 0;code = 48
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char = d;code = 100
char = a;code = 97
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char = s;code = 115
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char = ;code = 32
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char = p;code = 112
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char = ,;code = 44
char = ;code = 32
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char = a;code = 97
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char = v;code = 118
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char = q;code = 113
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char = h;code = 104
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char = d;code = 100
char = a;code = 97
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char = -;code = 45
char = 3;code = 51
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char = );code = 41
char = ;code = 32
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char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = o;code = 111
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char = v;code = 118
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char = c;code = 99
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char = a;code = 97
char = z;code = 122
char = o;code = 111
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char = e;code = 101
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char = 4;code = 52
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char = 0;code = 48
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char = m;code = 109
char = g;code = 103
char = ;code = 32
char = q;code = 113
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char = ,;code = 44
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char = d;code = 100
char = a;code = 97
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char = 5;code = 53
char = 7;code = 55
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char = 0;code = 48
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char = m;code = 109
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char = h;code = 104
char = ,;code = 44
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char = d;code = 100
char = a;code = 97
char = y;code = 121
char = s;code = 115
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char = 5;code = 53
char = 8;code = 56
char = -;code = 45
char = 6;code = 54
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char = a;code = 97
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char = o;code = 111
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char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = p;code = 112
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = (;code = 40
char = q;code = 113
char = 2;code = 50
char = 4;code = 52
char = ;code = 32
char = h;code = 104
char = ,;code = 44
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = y;code = 121
char = s;code = 115
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char = 4;code = 52
char = 0;code = 48
char = -;code = 45
char = 6;code = 54
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char = );code = 41
char = ;code = 32
char = (;code = 40
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = d;code = 100
char = ;code = 32
char = 3;code = 51
char = );code = 41
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = V;code = 86
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = z;code = 122
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char = l;code = 108
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char = C;code = 67
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char = t;code = 116
char = a;code = 97
char = u;code = 117
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char = a;code = 97
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char = i;code = 105
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char = c;code = 99
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char = a;code = 97
char = s;code = 115
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char = d;code = 100
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char = 4;code = 52
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char = (;code = 40
char = 1;code = 49
char = 2;code = 50
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char = 6;code = 54
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char = 2;code = 50
char = -;code = 45
char = 1;code = 49
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char = I;code = 73
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char = 2;code = 50
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char = 6;code = 54
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char = 1;code = 49
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char = 2;code = 50
char = 4;code = 52
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char = 5;code = 53
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char = -;code = 45
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char = ;;code = 59
char = ;code = 32
char = 9;code = 57
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char = %;code = 37
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char = C;code = 67
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char = 3;code = 51
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char = ;code = 32
char = 2;code = 50
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char = );code = 41
char = ,;code = 44
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char = r;code = 114
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char = s;code = 115
char = p;code = 112
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char = w;code = 119
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char = s;code = 115
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char = e;code = 101
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char = w;code = 119
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char = t;code = 116
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char = a;code = 97
char = l;code = 108
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
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char = v;code = 118
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = v;code = 118
char = o;code = 111
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char = a;code = 97
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char = ;code = 32
char = E;code = 69
char = t;code = 116
char = h;code = 104
char = i;code = 105
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char = y;code = 121
char = l;code = 108
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char = s;code = 115
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char = r;code = 114
char = a;code = 97
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char = m;code = 109
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char = t;code = 116
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char = i;code = 105
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char = m;code = 109
char = e;code = 101
char = a;code = 97
char = n;code = 110
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char = A;code = 65
char = U;code = 85
char = C;code = 67
char = (;code = 40
char = t;code = 116
char = a;code = 97
char = u;code = 117
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char = ;code = 32
char = a;code = 97
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char = C;code = 67
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char = m;code = 109
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char = a;code = 97
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char = 6;code = 54
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char = %;code = 37
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 0;code = 48
char = 3;code = 51
char = 1;code = 49
char = -;code = 45
char = 1;code = 49
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char = 5;code = 53
char = 7;code = 55
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char = h;code = 104
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char = -;code = 45
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char = ;;code = 59
char = ;code = 32
char = 9;code = 57
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char = %;code = 37
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char = C;code = 67
char = I;code = 73
char = ;code = 32
char = 5;code = 53
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char = ,;code = 44
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char = 7;code = 55
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char = 3;code = 51
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char = %;code = 37
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 1;code = 49
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char = -;code = 45
char = 1;code = 49
char = 6;code = 54
char = 1;code = 49
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char = ;;code = 59
char = ;code = 32
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char = C;code = 67
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char = ;code = 32
char = 2;code = 50
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char = A;code = 65
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char = t;code = 116
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char = a;code = 97
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char = 1;code = 49
char = 1;code = 49
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char = 1;code = 49
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char = ;;code = 59
char = ;code = 32
char = 9;code = 57
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char = %;code = 37
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char = C;code = 67
char = I;code = 73
char = ;code = 32
char = 4;code = 52
char = 4;code = 52
char = ,;code = 44
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char = 6;code = 54
char = 4;code = 52
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char = ;;code = 59
char = ;code = 32
char = 9;code = 57
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char = C;code = 67
char = I;code = 73
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char = 3;code = 51
char = ,;code = 44
char = ;code = 32
char = 2;code = 50
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char = N;code = 78
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result sql = WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT : * Voriconazole, a broad-spectrum antifungal drug, is a substrate and inhibitor of CYP2C19 and CYP3A4 isozymes. * Ethinyl oestradiol and norethindrone, components of the combination oral contraceptive drug Ortho-Novum 1/35, also are substrates of cytochrome P450 CYP2C19 and CYP3A4 isozymes. * Because co-administration of voriconazole and Ortho-Novum 1/35 could potentially result in pharmacokinetic interactions that increase systemic exposure of one or both drugs to unsafe levels, clinical studies are needed to define better the two-way pharmacokinetic interaction between these drugs.

WHAT THIS STUDY ADDS : * Although co-administered voriconazole and oral contraceptive did result in increased systemic exposures of all three drugs relative to respective monotherapy, co-administered treatment was generally safe and well tolerated. * It is recommended, however, that patients receiving co-administered voriconazole and oral contraceptives be monitored for the development of adverse events commonly associated with these medications.

AIM : To assess the two-way pharmacokinetic interaction between voriconazole and Ortho-Novum 1/35, an oral contraceptive containing norethindrone 1 mg and ethinyl oestradiol 35 microg.

METHODS : In this open-label, three-period, fixed-sequence study, 16 healthy females received voriconazole (400 mg q12 h, day 1; 200 mg q12 h, days 2-4) (period 1), oral contraceptive (q24 h, days 12-32) (period 2), and combination voriconazole (400 mg q12 h, day 57; 200 mg q12 h, days 58-60) and oral contraceptive (q24 h, days 40-60) (period 3).

RESULTS : Voriconazole geometric mean AUC(tau) and C(max) increased 46% (12 682-18 495 ng h ml(-1); 90% confidence interval [CI] 32, 61) and 14% (2485-2840 ng ml(-1); 90% CI 3, 27), respectively, when co-administered with oral contraceptive vs. voriconazole alone. Ethinyl oestradiol geometric mean AUC(tau) and C(max) increased 61% (1031-1657 ng h ml(-1); 90% CI 50, 72) and 36% (119-161 ng ml(-1); 90% CI 28, 45), respectively, and norethindrone geometric mean AUC(tau) and C(max) increased 53% (116-177 ng h ml(-1); 90% CI 44, 64) and 15% (18-20 ng ml(-1); 90% CI 3, 28), respectively, during voriconazole co-administration vs. oral contraceptive alone. Neither ethinyl oestradiol nor norethindrone levels were reduced in subjects following voriconazole co-administration. Adverse events (AEs) were generally mild, occurring less in subjects receiving voriconazole alone (36 events) vs. oral contraceptive alone (88 events) or combination treatment (68 events); four subjects experienced a severe AE.

CONCLUSIONS : Co-administration of voriconazole and oral contraceptive increased systemic exposures of all analytes relative to respective monotherapy. Although generally safe and well tolerated, it is recommended that patients receiving co-administered voriconazole and oral contraceptive be monitored for development of AEs commonly associated with these medications.

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