char = P;code = 80 char = h;code = 104 char = a;code = 97 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = I;code = 73 char = ;code = 32 char = c;code = 99 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = p;code = 112 char = h;code = 104 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = x;code = 120 char = i;code = 105 char = n;code = 110 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = l;code = 108 char = e;code = 101 char = u;code = 117 char = k;code = 107 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = f;code = 102 char = u;code = 117 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = y;code = 121 char = e;code = 101 char = l;code = 108 char = o;code = 111 char = i;code = 105 char = d;code = 100 char = ;code = 32 char = l;code = 108 char = e;code = 101 char = u;code = 117 char = k;code = 107 char = e;code = 101 char = m;code = 109 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = m;code = 109 char = y;code = 121 char = e;code = 101 char = l;code = 108 char = o;code = 111 char = d;code = 100 char = y;code = 121 char = s;code = 115 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = s;code = 115 char = i;code = 105 char = a;code = 97 char = .;code = 46 result sql = Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia.
Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia.char = D;code = 68 char = T;code = 84 char = (;code = 40 char = 3;code = 51 char = 8;code = 56 char = 8;code = 56 char = );code = 41 char = I;code = 73 char = L;code = 76 char = 3;code = 51 char = ;code = 32 char = f;code = 102 char = u;code = 117 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = a;code = 97 char = t;code = 116 char = a;code = 97 char = l;code = 108 char = y;code = 121 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = s;code = 115 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = m;code = 109 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = p;code = 112 char = h;code = 104 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = x;code = 120 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = f;code = 102 char = u;code = 117 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = h;code = 104 char = u;code = 117 char = m;code = 109 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = l;code = 108 char = e;code = 101 char = u;code = 117 char = k;code = 107 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = -;code = 45 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = s;code = 115 char = c;code = 99 char = a;code = 97 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = 1;code = 49 char = 5;code = 53 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = .;code = 46 char = v;code = 118 char = .;code = 46 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = f;code = 102 char = u;code = 117 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 6;code = 54 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = e;code = 101 char = m;code = 109 char = o;code = 111 char = -;code = 45 char = r;code = 114 char = e;code = 101 char = f;code = 102 char = r;code = 114 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = y;code = 121 char = e;code = 101 char = l;code = 108 char = o;code = 111 char = i;code = 105 char = d;code = 100 char = ;code = 32 char = l;code = 108 char = e;code = 101 char = u;code = 117 char = k;code = 107 char = e;code = 101 char = m;code = 109 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = (;code = 40 char = A;code = 65 char = M;code = 77 char = L;code = 76 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = m;code = 109 char = y;code = 121 char = e;code = 101 char = l;code = 108 char = o;code = 111 char = d;code = 100 char = y;code = 121 char = s;code = 115 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = s;code = 115 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = (;code = 40 char = M;code = 77 char = D;code = 68 char = S;code = 83 char = );code = 41 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = x;code = 120 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = l;code = 108 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = >;code = 62 char = 1;code = 49 char = 2;code = 50 char = .;code = 46 char = 5;code = 53 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = r;code = 114 char = o;code = 111 char = g;code = 103 char = /;code = 47 char = k;code = 107 char = g;code = 103 char = /;code = 47 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = a;code = 97 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = s;code = 115 char = a;code = 97 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = s;code = 115 char = e;code = 101 char = m;code = 109 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = a;code = 97 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = 2;code = 50 char = ;code = 32 char = f;code = 102 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = i;code = 105 char = l;code = 108 char = l;code = 108 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = h;code = 104 char = y;code = 121 char = p;code = 112 char = o;code = 111 char = a;code = 97 char = l;code = 108 char = b;code = 98 char = u;code = 117 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = m;code = 109 char = i;code = 105 char = a;code = 97 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = h;code = 104 char = y;code = 121 char = p;code = 112 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = c;code = 99 char = c;code = 99 char = u;code = 117 char = r;code = 114 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = .;code = 46 char = ;code = 32 char = P;code = 80 char = e;code = 101 char = a;code = 97 char = k;code = 107 char = ;code = 32 char = D;code = 68 char = T;code = 84 char = (;code = 40 char = 3;code = 51 char = 8;code = 56 char = 8;code = 56 char = );code = 41 char = I;code = 73 char = L;code = 76 char = 3;code = 51 char = ;code = 32 char = l;code = 108 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = r;code = 114 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = b;code = 98 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = b;code = 98 char = o;code = 111 char = d;code = 100 char = y;code = 121 char = ;code = 32 char = t;code = 116 char = i;code = 105 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = .;code = 46 char = ;code = 32 char = A;code = 65 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = -;code = 45 char = D;code = 68 char = T;code = 84 char = (;code = 40 char = 3;code = 51 char = 8;code = 56 char = 8;code = 56 char = );code = 41 char = I;code = 73 char = L;code = 76 char = 3;code = 51 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = b;code = 98 char = o;code = 111 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = l;code = 108 char = o;code = 111 char = p;code = 112 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = 1;code = 49 char = 5;code = 53 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 3;code = 51 char = 0;code = 48 char = .;code = 46 char = ;code = 32 char = O;code = 79 char = f;code = 102 char = ;code = 32 char = 4;code = 52 char = 0;code = 48 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = u;code = 117 char = a;code = 97 char = b;code = 98 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = A;code = 65 char = M;code = 77 char = L;code = 76 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = C;code = 67 char = R;code = 82 char = ;code = 32 char = (;code = 40 char = 8;code = 56 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = d;code = 100 char = ;code = 32 char = P;code = 80 char = R;code = 82 char = ;code = 32 char = (;code = 40 char = 3;code = 51 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = );code = 41 char = .;code = 46 char = ;code = 32 char = O;code = 79 char = f;code = 102 char = ;code = 32 char = 5;code = 53 char = ;code = 32 char = M;code = 77 char = D;code = 68 char = S;code = 83 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = P;code = 80 char = R;code = 82 char = ;code = 32 char = (;code = 40 char = 4;code = 52 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = );code = 41 char = .;code = 46 char = ;code = 32 char = B;code = 66 char = e;code = 101 char = c;code = 99 char = a;code = 97 char = u;code = 117 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = o;code = 111 char = n;code = 110 char = g;code = 103 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = f;code = 102 char = u;code = 117 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = c;code = 99 char = h;code = 104 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = l;code = 108 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = n;code = 110 char = y;code = 121 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = f;code = 102 char = a;code = 97 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = x;code = 120 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = D;code = 68 char = T;code = 84 char = (;code = 40 char = 3;code = 51 char = 8;code = 56 char = 8;code = 56 char = );code = 41 char = I;code = 73 char = L;code = 76 char = 3;code = 51 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = m;code = 109 char = i;code = 105 char = s;code = 115 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = a;code = 97 char = p;code = 112 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = /;code = 47 char = r;code = 114 char = e;code = 101 char = f;code = 102 char = r;code = 114 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = A;code = 65 char = M;code = 77 char = L;code = 76 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = M;code = 77 char = D;code = 68 char = S;code = 83 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = x;code = 120 char = i;code = 105 char = c;code = 99 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = c;code = 99 char = h;code = 104 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = l;code = 108 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = e;code = 101 char = d;code = 100 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = h;code = 104 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = p;code = 112 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 result sql = DT(388)IL3 fusion protein containing the catalytic and translocation domains of diphtheria toxin fused to human interleukin 3 was administered in an inter-patient dose escalation trial by 15 min i.v. infusions every other day for up to 6 doses to patients with chemo-refractory acute myeloid leukemia (AML) and myelodysplasia (MDS). The maximal tolerated dose was >12.5 microg/kg/dose. Transient grade 3 transaminasemia and grade 2 fevers, chills, hypoalbuminemia, and hypotension occurred. Peak DT(388)IL3 levels correlated with dose and day of administration but not antibody titer. Anti-DT(388)IL3 antibodies developed in most patients between day 15 and 30. Of 40 evaluable AML patients, 1 had a CR (8 months) and 1 had PR (3 months). Of 5 MDS patients, 1 had a PR (4 months). Because of the prolonged infusion schedule, many patients failed to receive six doses. DT(388)IL3 produces remissions in patients with relapsed/refractory AML and MDS with minimal toxicities, and alternate schedules of administration are needed to enhance the response rate.
Publication: Leuk. Lymphoma 2008 Mar ;49(3)::543-53.
Publication Date: 2008 Mar
Study Author(s): Frankel, Arthur;Liu, Jen-Sing;Rizzieri, David;Hogge, Donna;
Institution: Scott & White Cancer Research Institute, Temple, TX, USA.
Shortcut link to this study:
DT(388)IL3 fusion protein containing the catalytic and translocation domains of diphtheria toxin fused to human interleukin 3 was administered in an inter-patient dose escalation trial by 15 min i.v. infusions every other day for up to 6 doses to patients with chemo-refractory acute myeloid leukemia (AML) and myelodysplasia (MDS). The maximal tolerated dose was >12.5 microg/kg/dose. Transient grade 3 transaminasemia and grade 2 fevers, chills, hypoalbuminemia, and hypotension occurred. Peak DT(388)IL3 levels correlated with dose and day of administration but not antibody titer. Anti-DT(388)IL3 antibodies developed in most patients between day 15 and 30. Of 40 evaluable AML patients, 1 had a CR (8 months) and 1 had PR (3 months). Of 5 MDS patients, 1 had a PR (4 months). Because of the prolonged infusion schedule, many patients failed to receive six doses. DT(388)IL3 produces remissions in patients with relapsed/refractory AML and MDS with minimal toxicities, and alternate schedules of administration are needed to enhance the response rate.
PMID: 18297533