|
|
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char = o;code = 111
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char = n;code = 110
char = g;code = 103
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char = o;code = 111
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char = t;code = 116
char = e;code = 101
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char = i;code = 105
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char = l;code = 108
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char = e;code = 101
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char = a;code = 97
char = l;code = 108
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char = a;code = 97
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
result sql = Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.
Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.char = W;code = 87
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char = f;code = 102
char = e;code = 101
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char = o;code = 111
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char = c;code = 99
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char = l;code = 108
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char = ;code = 32
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char = i;code = 105
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char = F;code = 70
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char = u;code = 117
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char = g;code = 103
char = i;code = 105
char = o;code = 111
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char = e;code = 101
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char = i;code = 105
char = s;code = 115
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char = n;code = 110
char = d;code = 100
char = ;code = 32
char = V;code = 86
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char = G;code = 71
char = F;code = 70
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
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char = d;code = 100
char = ;code = 32
char = V;code = 86
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = R;code = 82
char = -;code = 45
char = 2;code = 50
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = r;code = 114
char = y;code = 121
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = H;code = 72
char = U;code = 85
char = V;code = 86
char = E;code = 69
char = C;code = 67
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = 3;code = 51
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char = A;code = 65
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = y;code = 121
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char = h;code = 104
char = a;code = 97
char = m;code = 109
char = a;code = 97
char = u;code = 117
char = d;code = 100
char = o;code = 111
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char = ;code = 32
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = i;code = 105
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char = u;code = 117
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = d;code = 100
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char = t;code = 116
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char = o;code = 111
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char = g;code = 103
char = h;code = 104
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char = m;code = 109
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char = c;code = 99
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char = ;code = 32
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char = s;code = 115
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char = e;code = 101
char = m;code = 109
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char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = s;code = 115
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = e;code = 101
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
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char = l;code = 108
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char = t;code = 116
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char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
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char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = n;code = 110
char = g;code = 103
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char = m;code = 109
char = i;code = 105
char = c;code = 99
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char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice.
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char = t;code = 116
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char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = 3;code = 51
char = ';code = 39
char = -;code = 45
char = O;code = 79
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char = a;code = 97
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char = a;code = 97
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char = g;code = 103
char = i;code = 105
char = o;code = 111
char = g;code = 103
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char = e;code = 101
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char = i;code = 105
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = e;code = 101
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char = n;code = 110
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char = r;code = 114
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char = p;code = 112
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char = t;code = 116
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char = e;code = 101
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char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = y;code = 121
char = m;code = 109
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char = h;code = 104
char = o;code = 111
char = c;code = 99
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char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
result sql = Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.
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char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = i;code = 105
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char = a;code = 97
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char = v;code = 118
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = t;code = 116
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char = r;code = 114
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char = g;code = 103
char = h;code = 104
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
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char = o;code = 111
char = r;code = 114
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char = u;code = 117
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char = d;code = 100
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char = i;code = 105
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
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char = s;code = 115
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char = b;code = 98
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char = t;code = 116
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char = t;code = 116
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char = e;code = 101
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char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
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char = s;code = 115
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char = b;code = 98
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = A;code = 65
char = n;code = 110
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char = e;code = 101
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char = i;code = 105
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char = j;code = 106
char = a;code = 97
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char = i;code = 105
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char = a;code = 97
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char = r;code = 114
char = o;code = 111
char = o;code = 111
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char = s;code = 115
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char = e;code = 101
char = ;code = 32
char = u;code = 117
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char = k;code = 107
char = n;code = 110
char = o;code = 111
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char = n;code = 110
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char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = t;code = 116
char = e;code = 101
char = m;code = 109
char = p;code = 112
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = f;code = 102
char = y;code = 121
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = o;code = 111
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = m;code = 109
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char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
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char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
char = r;code = 114
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char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = 3;code = 51
char = ';code = 39
char = -;code = 45
char = O;code = 79
char = -;code = 45
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = y;code = 121
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char = h;code = 104
char = a;code = 97
char = m;code = 109
char = a;code = 97
char = u;code = 117
char = d;code = 100
char = o;code = 111
char = l;code = 108
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char = i;code = 105
char = s;code = 115
char = o;code = 111
char = l;code = 108
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = A;code = 65
char = .;code = 46
char = ;code = 32
char = j;code = 106
char = a;code = 97
char = p;code = 112
char = o;code = 111
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char = i;code = 105
char = c;code = 99
char = a;code = 97
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = o;code = 111
char = t;code = 116
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = r;code = 114
char = s;code = 115
char = t;code = 116
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char = e;code = 101
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char = n;code = 110
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char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 3;code = 51
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char = -;code = 45
char = O;code = 79
char = -;code = 45
char = a;code = 97
char = c;code = 99
char = e;code = 101
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char = y;code = 121
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char = a;code = 97
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char = a;code = 97
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char = d;code = 100
char = o;code = 111
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char = o;code = 111
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char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = t;code = 116
char = h;code = 104
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char = i;code = 105
char = n;code = 110
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char = c;code = 99
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char = l;code = 108
char = o;code = 111
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char = ;code = 32
char = 2;code = 50
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char = b;code = 98
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char = a;code = 97
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char = m;code = 109
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char = c;code = 99
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char = F;code = 70
char = u;code = 117
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char = e;code = 101
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char = a;code = 97
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char = 2;code = 50
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char = V;code = 86
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = R;code = 82
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char = l;code = 108
char = s;code = 115
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char = H;code = 72
char = U;code = 85
char = V;code = 86
char = E;code = 69
char = C;code = 67
char = s;code = 115
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char = ,;code = 44
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char = a;code = 97
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char = a;code = 97
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char = (;code = 40
char = V;code = 86
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = );code = 41
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char = O;code = 79
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char = 3;code = 51
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char = O;code = 79
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char = a;code = 97
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char = e;code = 101
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char = f;code = 102
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char = V;code = 86
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char = G;code = 71
char = F;code = 70
char = ;code = 32
char = p;code = 112
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char = n;code = 110
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char = a;code = 97
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char = d;code = 100
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char = H;code = 72
char = I;code = 73
char = F;code = 70
char = -;code = 45
char = 1;code = 49
char = a;code = 97
char = l;code = 108
char = p;code = 112
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char = i;code = 105
char = t;code = 116
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char = m;code = 109
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result sql = We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice.
Publication: Cancer Lett. 2008 Jun 28 ;265(1)::84-97. :doi: 10.1016/j.canlet.2008.02.009.
Publication Date: 2008 Jun 28
Study Author(s): Kimura, Yoshiyuki;Sumiyoshi, Maho;Baba, Kimiye;
Institution: Division of Biochemical Pharmacology, Department of Basic Medical Research Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791-0295, Japan. [email protected]
Shortcut link to this study:
Publication Date: 2008 Jun 28
Study Author(s): Kimura, Yoshiyuki;Sumiyoshi, Maho;Baba, Kimiye;
Institution: Division of Biochemical Pharmacology, Department of Basic Medical Research Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791-0295, Japan. [email protected]
Shortcut link to this study:
We recently demonstrated that two chalcones isolated from Angelica keiskei roots have anti-tumor and anti-metastatic activities through the inhibition of tumor-induced angiogenesis, but the anti-tumor substances of Angelica japonica roots are unknown. We attempted to clarify the anti-tumor action and its mechanisms of a major component 3'-O-acetylhamaudol isolated from A. japonica roots. We first examined the effects of 3'-O-acetylhamaudol on tumor growth in colon 26-bearing mice. Furthermore, we examined the effects of 3'-O-acetylhamaudol on angiogenic factors (vascular endothelial growth factor receptor-2 (VEGFR-2) phosphorylation in human umbilical vein endothelial cells (HUVECs), and vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor (HIF)-1alpha expression in tumors). 3'-O-Acetylhamaudol (25 and 50 mg/kg, twice daily) inhibited the tumor growth in colon 26-bearing mice. Although 3'-O-acetylhamudol had no effect on the VEGF production and HIF-1alpha in colon 26 cells, it (10 microM) inhibited the VEGF-induced angiogenesis and VEGF-induced VEGFR-2 phosphorylation in HUVECs. 3'-O-Acetylhamaudol has anti-tumor effects mediated through dual mechanisms, i.e., anti-angiogenic actions and the modulation of the immune system in the spleen and small intestine in tumor-bearing mice.
PMID: 18358599
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