|
|
char = A;code = 65
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char = t;code = 116
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = m;code = 109
char = m;code = 109
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char = r;code = 114
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char = a;code = 97
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char = t;code = 116
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = 6;code = 54
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char = I;code = 73
char = L;code = 76
char = );code = 41
char = ;code = 32
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char = o;code = 111
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char = o;code = 111
char = l;code = 108
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char = e;code = 101
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char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = -;code = 45
char = a;code = 97
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char = t;code = 116
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char = c;code = 99
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char = o;code = 111
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char = s;code = 115
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char = (;code = 40
char = P;code = 80
char = P;code = 80
char = A;code = 65
char = R;code = 82
char = );code = 41
char = .;code = 46
result sql = Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR).
Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR).char = <;code = 60
char = b;code = 98
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char = I;code = 73
char = N;code = 78
char = T;code = 84
char = R;code = 82
char = O;code = 79
char = D;code = 68
char = U;code = 85
char = C;code = 67
char = T;code = 84
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
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char = b;code = 98
char = >;code = 62
char = S;code = 83
char = t;code = 116
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char = h;code = 104
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char = ;code = 32
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char = a;code = 97
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char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
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char = m;code = 109
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char = M;code = 77
char = N;code = 78
char = U;code = 85
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char = g;code = 103
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char = g;code = 103
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char = b;code = 98
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char = A;code = 65
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char = <;code = 60
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result sql = INTRODUCTION : Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro, however the cellular intermediated involved in these effects has not been elucidated.
METHODS : Virgin Sprague-Dawley rats were treated with methyl-nitrosourea (MNU: single dose ip, 50 mg/Kg bw) and the participation of arachidonic acid (AA) and PPAR receptors in the antineoplasic effect of I2 where analyzed.
RESULTS : I2-treated rats for four weeks exhibited a significant reduction in the incidence (62.5 vs. 100%) and size (0.87 +/- 0.98 vs 1.96 +/- 1.5 cm3) of mammary tumors. HPLC analysis showed that tumoral but not normal mammary tissue contained an elevated basal concentration of AA and significantly more AA-iodinated called 6-iodolactone (6-IL) after chronic I2 treatment. Tumors from I2-treated rats showed fewer cells positive to proliferating cell nuclear antigen, lower blood vessel density, as well as decreases in vascular endothelial growth factor, urokinase-type plasminogen activator, and PPAR type alpha (PPARalpha). These same tumors showed increases in the cell death markers, TUNEL-positive cells (p < 0.05) and the enzyme caspase-3 (trend), as well as significant induction of PPAR type gamma (PPARgamma).
CONCLUSION : Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARgamma induction.
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result sql = Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR).
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result sql = INTRODUCTION : Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro, however the cellular intermediated involved in these effects has not been elucidated.
METHODS : Virgin Sprague-Dawley rats were treated with methyl-nitrosourea (MNU: single dose ip, 50 mg/Kg bw) and the participation of arachidonic acid (AA) and PPAR receptors in the antineoplasic effect of I2 where analyzed.
RESULTS : I2-treated rats for four weeks exhibited a significant reduction in the incidence (62.5 vs. 100%) and size (0.87 +/- 0.98 vs 1.96 +/- 1.5 cm3) of mammary tumors. HPLC analysis showed that tumoral but not normal mammary tissue contained an elevated basal concentration of AA and significantly more AA-iodinated called 6-iodolactone (6-IL) after chronic I2 treatment. Tumors from I2-treated rats showed fewer cells positive to proliferating cell nuclear antigen, lower blood vessel density, as well as decreases in vascular endothelial growth factor, urokinase-type plasminogen activator, and PPAR type alpha (PPARalpha). These same tumors showed increases in the cell death markers, TUNEL-positive cells (p < 0.05) and the enzyme caspase-3 (trend), as well as significant induction of PPAR type gamma (PPARgamma).
CONCLUSION : Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARgamma induction.
Publication: Mol. Cancer 2009 ;8:33. :doi: 10.1186/1476-4598-8-33.
Publication Date: 2009
Study Author(s): Aceves, Carmen;García-Solís, Pablo;Arroyo-Helguera, Omar;Vega-Riveroll, Laura;Delgado, Guadalupe;Anguiano, Brenda;
Institution: Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, México. [email protected]
Shortcut link to this study:
Publication Date: 2009
Study Author(s): Aceves, Carmen;García-Solís, Pablo;Arroyo-Helguera, Omar;Vega-Riveroll, Laura;Delgado, Guadalupe;Anguiano, Brenda;
Institution: Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro, México. [email protected]
Shortcut link to this study:
INTRODUCTION : Studies in mammary cancer demonstrated that moderately high concentrations of molecular iodine (I2) have a antiproliferative and apoptotic effect either in vivo as in vitro, however the cellular intermediated involved in these effects has not been elucidated.
METHODS : Virgin Sprague-Dawley rats were treated with methyl-nitrosourea (MNU: single dose ip, 50 mg/Kg bw) and the participation of arachidonic acid (AA) and PPAR receptors in the antineoplasic effect of I2 where analyzed.
RESULTS : I2-treated rats for four weeks exhibited a significant reduction in the incidence (62.5 vs. 100%) and size (0.87 +/- 0.98 vs 1.96 +/- 1.5 cm3) of mammary tumors. HPLC analysis showed that tumoral but not normal mammary tissue contained an elevated basal concentration of AA and significantly more AA-iodinated called 6-iodolactone (6-IL) after chronic I2 treatment. Tumors from I2-treated rats showed fewer cells positive to proliferating cell nuclear antigen, lower blood vessel density, as well as decreases in vascular endothelial growth factor, urokinase-type plasminogen activator, and PPAR type alpha (PPARalpha). These same tumors showed increases in the cell death markers, TUNEL-positive cells (p < 0.05) and the enzyme caspase-3 (trend), as well as significant induction of PPAR type gamma (PPARgamma).
CONCLUSION : Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARgamma induction.
METHODS : Virgin Sprague-Dawley rats were treated with methyl-nitrosourea (MNU: single dose ip, 50 mg/Kg bw) and the participation of arachidonic acid (AA) and PPAR receptors in the antineoplasic effect of I2 where analyzed.
RESULTS : I2-treated rats for four weeks exhibited a significant reduction in the incidence (62.5 vs. 100%) and size (0.87 +/- 0.98 vs 1.96 +/- 1.5 cm3) of mammary tumors. HPLC analysis showed that tumoral but not normal mammary tissue contained an elevated basal concentration of AA and significantly more AA-iodinated called 6-iodolactone (6-IL) after chronic I2 treatment. Tumors from I2-treated rats showed fewer cells positive to proliferating cell nuclear antigen, lower blood vessel density, as well as decreases in vascular endothelial growth factor, urokinase-type plasminogen activator, and PPAR type alpha (PPARalpha). These same tumors showed increases in the cell death markers, TUNEL-positive cells (p < 0.05) and the enzyme caspase-3 (trend), as well as significant induction of PPAR type gamma (PPARgamma).
CONCLUSION : Together, these data demonstrate that the antineoplasic effect of iodine involves 6-IL formation and PPARgamma induction.
PMID: 19500378
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