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result sql = Fruit and vegetable consumption has been hypothesized to reduce the risk of renal cell cancer. We conducted a pooled analysis of 13 prospective studies, including 1,478 incident cases of renal cell cancer (709 women and 769 men) among 530,469 women and 244,483 men followed for up to 7 to 20 years. Participants completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RR) were calculated using the Cox proportional hazards model and then pooled using a random effects model. We found that fruit and vegetable consumption was associated with a reduced risk of renal cell cancer. Compared with <200 g/d of fruit and vegetable intake, the pooled multivariate RR for >or=600 g/d was 0.68 [95% confidence interval (95% CI) = 0.54-0.87; P for between-studies heterogeneity = 0.86; P for trend = 0.001]. Compared with <100 g/d, the pooled multivariate RRs (95% CI) for >or=400 g/d were 0.79 (0.63-0.99; P for trend = 0.03) for total fruit and 0.72 (0.48-1.08; P for trend = 0.07) for total vegetables. For specific carotenoids, the pooled multivariate RRs (95% CIs) comparing the highest and lowest quintiles were 0.87 (0.73-1.03) for alpha-carotene, 0.82 (0.69-0.98) for beta-carotene, 0.86 (0.73-1.01) for beta-cryptoxanthin, 0.82 (0.64-1.06) for lutein/zeaxanthin, and 1.13 (0.95-1.34) for lycopene. In conclusion, increasing fruit and vegetable consumption is associated with decreasing risk of renal cell cancer; carotenoids present in fruit and vegetables may partly contribute to this protection.
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char = t;code = 116
char = u;code = 117
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char = e;code = 101
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char = .;code = 46
result sql = Intakes of fruit, vegetables, and carotenoids and renal cell cancer risk: a pooled analysis of 13 prospective studies.
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char = e;code = 101
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char = m;code = 109
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char = b;code = 98
char = e;code = 101
char = e;code = 101
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char = y;code = 121
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char = i;code = 105
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char = e;code = 101
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char = e;code = 101
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char = k;code = 107
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char = ;code = 32
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char = n;code = 110
char = a;code = 97
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = W;code = 87
char = e;code = 101
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char = c;code = 99
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char = d;code = 100
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char = a;code = 97
char = ;code = 32
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char = o;code = 111
char = o;code = 111
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char = a;code = 97
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char = a;code = 97
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char = y;code = 121
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 1;code = 49
char = 3;code = 51
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = i;code = 105
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char = c;code = 99
char = l;code = 108
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = 1;code = 49
char = ,;code = 44
char = 4;code = 52
char = 7;code = 55
char = 8;code = 56
char = ;code = 32
char = i;code = 105
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char = c;code = 99
char = i;code = 105
char = d;code = 100
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char = t;code = 116
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char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = f;code = 102
char = ;code = 32
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char = n;code = 110
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char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = 7;code = 55
char = 0;code = 48
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char = w;code = 119
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char = d;code = 100
char = ;code = 32
char = 7;code = 55
char = 6;code = 54
char = 9;code = 57
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = );code = 41
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char = a;code = 97
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char = g;code = 103
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char = 5;code = 53
char = 3;code = 51
char = 0;code = 48
char = ,;code = 44
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char = 6;code = 54
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char = w;code = 119
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char = a;code = 97
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char = 2;code = 50
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char = 4;code = 52
char = ,;code = 44
char = 4;code = 52
char = 8;code = 56
char = 3;code = 51
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char = m;code = 109
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char = ;code = 32
char = f;code = 102
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char = l;code = 108
char = l;code = 108
char = o;code = 111
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = 7;code = 55
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = 2;code = 50
char = 0;code = 48
char = ;code = 32
char = y;code = 121
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = .;code = 46
char = ;code = 32
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char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = p;code = 112
char = a;code = 97
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char = s;code = 115
char = ;code = 32
char = c;code = 99
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char = p;code = 112
char = l;code = 108
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = l;code = 108
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char = d;code = 100
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
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char = o;code = 111
char = d;code = 100
char = -;code = 45
char = f;code = 102
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char = e;code = 101
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char = e;code = 101
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char = y;code = 121
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char = q;code = 113
char = u;code = 117
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char = a;code = 97
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char = .;code = 46
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char = U;code = 85
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char = n;code = 110
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char = r;code = 114
char = y;code = 121
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char = d;code = 100
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char = a;code = 97
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = e;code = 101
char = a;code = 97
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
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char = y;code = 121
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char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = s;code = 115
char = ;code = 32
char = (;code = 40
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char = R;code = 82
char = );code = 41
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char = e;code = 101
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char = l;code = 108
char = a;code = 97
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char = e;code = 101
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char = f;code = 102
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char = R;code = 82
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result sql = Fruit and vegetable consumption has been hypothesized to reduce the risk of renal cell cancer. We conducted a pooled analysis of 13 prospective studies, including 1,478 incident cases of renal cell cancer (709 women and 769 men) among 530,469 women and 244,483 men followed for up to 7 to 20 years. Participants completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RR) were calculated using the Cox proportional hazards model and then pooled using a random effects model. We found that fruit and vegetable consumption was associated with a reduced risk of renal cell cancer. Compared with <200 g/d of fruit and vegetable intake, the pooled multivariate RR for >or=600 g/d was 0.68 [95% confidence interval (95% CI) = 0.54-0.87; P for between-studies heterogeneity = 0.86; P for trend = 0.001]. Compared with <100 g/d, the pooled multivariate RRs (95% CI) for >or=400 g/d were 0.79 (0.63-0.99; P for trend = 0.03) for total fruit and 0.72 (0.48-1.08; P for trend = 0.07) for total vegetables. For specific carotenoids, the pooled multivariate RRs (95% CIs) comparing the highest and lowest quintiles were 0.87 (0.73-1.03) for alpha-carotene, 0.82 (0.69-0.98) for beta-carotene, 0.86 (0.73-1.01) for beta-cryptoxanthin, 0.82 (0.64-1.06) for lutein/zeaxanthin, and 1.13 (0.95-1.34) for lycopene. In conclusion, increasing fruit and vegetable consumption is associated with decreasing risk of renal cell cancer; carotenoids present in fruit and vegetables may partly contribute to this protection.
Publication: Cancer Epidemiol. Biomarkers Prev. 2009 Jun ;18(6)::1730-9. :doi: 10.1158/1055-9965.EPI-09-0045.
Publication Date: 2009 Jun
Study Author(s): Lee, Jung Eun;Männistö, Satu;Spiegelman, Donna;Hunter, David J;Bernstein, Leslie;van den Brandt, Piet A;Buring, Julie E;Cho, Eunyoung;English, Dallas R;Flood, Andrew;Freudenheim, Jo L;Giles, Graham G;Giovannucci, Edward;Håkansson, Niclas;Horn-Ross, Pamela L;Jacobs, Eric J;Leitzmann, Michael F;Marshall, James R;McCullough, Marjorie L;Miller, Anthony B;Rohan, Thomas E;Ross, Julie A;Schatzkin, Arthur;Schouten, Leo J;Virtamo, Jarmo;Wolk, Alicja;Zhang, Shumin M;Smith-Warner, Stephanie A;
Institution: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. [email protected]
Shortcut link to this study:
Publication Date: 2009 Jun
Study Author(s): Lee, Jung Eun;Männistö, Satu;Spiegelman, Donna;Hunter, David J;Bernstein, Leslie;van den Brandt, Piet A;Buring, Julie E;Cho, Eunyoung;English, Dallas R;Flood, Andrew;Freudenheim, Jo L;Giles, Graham G;Giovannucci, Edward;Håkansson, Niclas;Horn-Ross, Pamela L;Jacobs, Eric J;Leitzmann, Michael F;Marshall, James R;McCullough, Marjorie L;Miller, Anthony B;Rohan, Thomas E;Ross, Julie A;Schatzkin, Arthur;Schouten, Leo J;Virtamo, Jarmo;Wolk, Alicja;Zhang, Shumin M;Smith-Warner, Stephanie A;
Institution: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. [email protected]
Shortcut link to this study:
Fruit and vegetable consumption has been hypothesized to reduce the risk of renal cell cancer. We conducted a pooled analysis of 13 prospective studies, including 1,478 incident cases of renal cell cancer (709 women and 769 men) among 530,469 women and 244,483 men followed for up to 7 to 20 years. Participants completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RR) were calculated using the Cox proportional hazards model and then pooled using a random effects model. We found that fruit and vegetable consumption was associated with a reduced risk of renal cell cancer. Compared with <200 g/d of fruit and vegetable intake, the pooled multivariate RR for >or=600 g/d was 0.68 [95% confidence interval (95% CI) = 0.54-0.87; P for between-studies heterogeneity = 0.86; P for trend = 0.001]. Compared with <100 g/d, the pooled multivariate RRs (95% CI) for >or=400 g/d were 0.79 (0.63-0.99; P for trend = 0.03) for total fruit and 0.72 (0.48-1.08; P for trend = 0.07) for total vegetables. For specific carotenoids, the pooled multivariate RRs (95% CIs) comparing the highest and lowest quintiles were 0.87 (0.73-1.03) for alpha-carotene, 0.82 (0.69-0.98) for beta-carotene, 0.86 (0.73-1.01) for beta-cryptoxanthin, 0.82 (0.64-1.06) for lutein/zeaxanthin, and 1.13 (0.95-1.34) for lycopene. In conclusion, increasing fruit and vegetable consumption is associated with decreasing risk of renal cell cancer; carotenoids present in fruit and vegetables may partly contribute to this protection.
PMID: 19505906
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