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result sql = Development of a broad-spectrum antiviral with activity against Ebola virus.
Development of a broad-spectrum antiviral with activity against Ebola virus.
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result sql = We report herein the identification of a small molecule therapeutic, FGI-106, which displays potent and broad-spectrum inhibition of lethal viral hemorrhagic fevers pathogens, including Ebola, Rift Valley and Dengue Fever viruses, in cell-based assays. Using mouse models of Ebola virus, we further demonstrate that FGI-106 can protect animals from an otherwise lethal infection when used either in a prophylactic or therapeutic setting. A single treatment, administered 1 day after infection, is sufficient to protect animals from lethal Ebola virus challenge. Cell-based assays also identified inhibitory activity against divergent virus families, which supports a hypothesis that FGI-106 interferes with a common pathway utilized by different viruses. These findings suggest FGI-106 may provide an opportunity for targeting viral diseases.

Publication: Antiviral Res. 2009 Sep ;83(3)::245-51. :doi: 10.1016/j.antiviral.2009.06.001.
Publication Date: 2009 Sep
Study Author(s): Aman, M Javad;Kinch, Michael S;Warfield, Kelly;Warren, Travis;Yunus, Abdul;Enterlein, Sven;Stavale, Eric;Wang, Peifang;Chang, Shaojing;Tang, Qingsong;Porter, Kevin;Goldblatt, Michael;Bavari, Sina;
Institution: United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD 21702, USA. [email protected]
Shortcut link to this study:
We report herein the identification of a small molecule therapeutic, FGI-106, which displays potent and broad-spectrum inhibition of lethal viral hemorrhagic fevers pathogens, including Ebola, Rift Valley and Dengue Fever viruses, in cell-based assays. Using mouse models of Ebola virus, we further demonstrate that FGI-106 can protect animals from an otherwise lethal infection when used either in a prophylactic or therapeutic setting. A single treatment, administered 1 day after infection, is sufficient to protect animals from lethal Ebola virus challenge. Cell-based assays also identified inhibitory activity against divergent virus families, which supports a hypothesis that FGI-106 interferes with a common pathway utilized by different viruses. These findings suggest FGI-106 may provide an opportunity for targeting viral diseases.
PMID: 19523489

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