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char = c;code = 99
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char = .;code = 46
result sql = Vitamin D for the prevention and treatment of pancreatic cancer.
Vitamin D for the prevention and treatment of pancreatic cancer.
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char = c;code = 99
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char = f;code = 102
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char = C;code = 67
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char = r;code = 114
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char = i;code = 105
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char = ;code = 32
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char = e;code = 101
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char = o;code = 111
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char = y;code = 121
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = v;code = 118
char = e;code = 101
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char = t;code = 116
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char = r;code = 114
char = a;code = 97
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char = .;code = 46
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char = a;code = 97
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char = l;code = 108
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char = a;code = 97
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char = i;code = 105
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char = a;code = 97
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char = c;code = 99
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char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = i;code = 105
char = v;code = 118
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
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char = a;code = 97
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char = t;code = 116
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char = r;code = 114
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char = c;code = 99
char = o;code = 111
char = l;code = 108
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char = ;code = 32
char = S;code = 83
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char = m;code = 109
char = i;code = 105
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = l;code = 108
char = y;code = 121
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = u;code = 117
char = m;code = 109
char = o;code = 111
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = a;code = 97
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char = 2;code = 50
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char = O;code = 79
char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = D;code = 68
char = (;code = 40
char = 3;code = 51
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char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = p;code = 112
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = e;code = 101
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = h;code = 104
char = a;code = 97
char = s;code = 115
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char = b;code = 98
char = e;code = 101
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char = n;code = 110
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char = d;code = 100
char = e;code = 101
char = m;code = 109
char = o;code = 111
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 1;code = 49
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = ,;code = 44
char = 2;code = 50
char = 5;code = 53
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char = O;code = 79
char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = D;code = 68
char = (;code = 40
char = 3;code = 51
char = );code = 41
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = e;code = 101
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = l;code = 108
char = e;code = 101
char = t;code = 116
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char = a;code = 97
char = l;code = 108
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char = s;code = 115
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char = d;code = 100
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = p;code = 112
char = e;code = 101
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
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char = e;code = 101
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char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = u;code = 117
char = r;code = 114
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char = a;code = 97
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char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = 2;code = 50
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char = O;code = 79
char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = D;code = 68
char = (;code = 40
char = 3;code = 51
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char = ;code = 32
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char = a;code = 97
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char = o;code = 111
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char = i;code = 105
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char = e;code = 101
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char = e;code = 101
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char = t;code = 116
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char = e;code = 101
char = r;code = 114
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char = e;code = 101
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char = i;code = 105
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char = a;code = 97
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char = O;code = 79
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char = (;code = 40
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char = t;code = 116
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char = a;code = 97
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char = f;code = 102
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char = R;code = 82
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char = c;code = 99
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char = s;code = 115
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char = p;code = 112
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char = a;code = 97
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char = O;code = 79
char = H;code = 72
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char = (;code = 40
char = 2;code = 50
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char = D;code = 68
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char = D;code = 68
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char = a;code = 97
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char = ;code = 32
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char = o;code = 111
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char = e;code = 101
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char = S;code = 83
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char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = r;code = 114
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = P;code = 80
char = a;code = 97
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char = c;code = 99
char = a;code = 97
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char = a;code = 97
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char = p;code = 112
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char = a;code = 97
char = ,;code = 44
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char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
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char = D;code = 68
char = (;code = 40
char = 3;code = 51
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char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = ;code = 32
char = i;code = 105
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char = n;code = 110
char = a;code = 97
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
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char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
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char = o;code = 111
char = r;code = 114
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char = e;code = 101
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char = t;code = 116
char = i;code = 105
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char = ;code = 32
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char = a;code = 97
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result sql = Pancreatic cancer is ranked fifth among cancer-related deaths worldwide with a 5-year survival rate of less than 5%. Currently, surgery is the only effective therapy. However, most patients are diagnosed in the late stage and are not suitable for receiving curative surgery. Moreover, pancreatic cancer doesn't respond well to traditional chemotherapy and radiotherapy, leaving little effective treatment for advanced pancreatic cancer cases. 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], the biologically active form of vitamin D(3), was originally identified during studies of calcium and bone metabolism, though it is now recognized that it exerts biological effects in almost every tissue in the body. Abundant evidence has shown that 1alpha,25(OH)(2)D(3) has antiproliferative, apoptotic, pro-differentiation and antiangiogensis effects in many types of cancer cells in vivo and in vitro, including breast, prostate, and colon. Similarly, the antitumor growth effect of 1alpha,25(OH)(2)D(3) on pancreatic cells has been demonstrated. The clinical use of 1alpha,25(OH)(2)D(3) is impeded by the lethal side effects of hypercalcemia and hypercalciuria. Therefore, 1alpha,25(OH)(2)D(3) analogs, which are either equipotent or more potent than 1alpha,25(OH)(2)D(3) in inhibiting tumor cell growth but with fewer hypercalcemic and hypercalciuric side effects, have been developed for the treatment of different cancers. Recently, a pre-clinical study demonstrated that a less calcemic analog of 1alpha,25(OH)(2)D(3), 19-nor-1alpha,25(OH)(2)D(2) (Paricalcitol), is effective in inhibiting tumor growth in vitro and in vivo, via upregulation of p21 and p27 tumor suppressor genes. Studies on the anti-tumor effects of a more potent analog of Paricalcitol are underway. 1alpha,25(OH)(2)D(3) and its analogs are potentially attractive novel therapies for pancreatic cancer.

Publication: World J. Gastroenterol. 2009 Jul 21 ;15(27)::3349-54.
Publication Date: 2009 Jul 21
Study Author(s): Chiang, Kun-Chun;Chen, Tai C;
Institution: Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, China. [email protected]
Shortcut link to this study:
Pancreatic cancer is ranked fifth among cancer-related deaths worldwide with a 5-year survival rate of less than 5%. Currently, surgery is the only effective therapy. However, most patients are diagnosed in the late stage and are not suitable for receiving curative surgery. Moreover, pancreatic cancer doesn't respond well to traditional chemotherapy and radiotherapy, leaving little effective treatment for advanced pancreatic cancer cases. 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], the biologically active form of vitamin D(3), was originally identified during studies of calcium and bone metabolism, though it is now recognized that it exerts biological effects in almost every tissue in the body. Abundant evidence has shown that 1alpha,25(OH)(2)D(3) has antiproliferative, apoptotic, pro-differentiation and antiangiogensis effects in many types of cancer cells in vivo and in vitro, including breast, prostate, and colon. Similarly, the antitumor growth effect of 1alpha,25(OH)(2)D(3) on pancreatic cells has been demonstrated. The clinical use of 1alpha,25(OH)(2)D(3) is impeded by the lethal side effects of hypercalcemia and hypercalciuria. Therefore, 1alpha,25(OH)(2)D(3) analogs, which are either equipotent or more potent than 1alpha,25(OH)(2)D(3) in inhibiting tumor cell growth but with fewer hypercalcemic and hypercalciuric side effects, have been developed for the treatment of different cancers. Recently, a pre-clinical study demonstrated that a less calcemic analog of 1alpha,25(OH)(2)D(3), 19-nor-1alpha,25(OH)(2)D(2) (Paricalcitol), is effective in inhibiting tumor growth in vitro and in vivo, via upregulation of p21 and p27 tumor suppressor genes. Studies on the anti-tumor effects of a more potent analog of Paricalcitol are underway. 1alpha,25(OH)(2)D(3) and its analogs are potentially attractive novel therapies for pancreatic cancer.
PMID: 19610135

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