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result sql = Liquid chromatography (LC) coupled with mass spectrometry (MS) detection is one of the most powerful analytical tools for organic compound analysis. THE ADVANTAGES OF USING LC/MS METHODS OVER HPLC METHODS INCLUDE: selectivity, chromatographic integrity, peak assignment, structural information, and rapid method development. In this paper, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of bisoprolol in human plasma samples, using metoprolol as internal standard and liquid-liquid extraction procedure. The assay has proven to be sensitive, specific and reproducible, suitable to determine the bisoprolol concentration, following a single oral administration of a 10 mg bisoprolol tablet in 22 healthy volunteers, in the bioequivalence study of Bisoprolol 10 mg coated tablets, produced by Antibiotice S.A. versus Concor 10 mg, produced by Merck.
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result sql = A new liquid chromatography-tandem mass spectrometry method for determination of bisoprolol in human plasma samples.
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result sql = Liquid chromatography (LC) coupled with mass spectrometry (MS) detection is one of the most powerful analytical tools for organic compound analysis. THE ADVANTAGES OF USING LC/MS METHODS OVER HPLC METHODS INCLUDE: selectivity, chromatographic integrity, peak assignment, structural information, and rapid method development. In this paper, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of bisoprolol in human plasma samples, using metoprolol as internal standard and liquid-liquid extraction procedure. The assay has proven to be sensitive, specific and reproducible, suitable to determine the bisoprolol concentration, following a single oral administration of a 10 mg bisoprolol tablet in 22 healthy volunteers, in the bioequivalence study of Bisoprolol 10 mg coated tablets, produced by Antibiotice S.A. versus Concor 10 mg, produced by Merck.
Publication: J. Biomed. Biotechnol. 2009 ;2009:736327. :doi: 10.1155/2009/736327.
Publication Date: 2009
Study Author(s): Peste, Gabriela;Bibire, Nela;Apostu, Mihai;Vlase, Aurel;Oniscu, Corneliu;
Institution: Center for Drug Evaluation, Antibiotice S.A., Iasi, Romania. [email protected]
Shortcut link to this study:
Publication Date: 2009
Study Author(s): Peste, Gabriela;Bibire, Nela;Apostu, Mihai;Vlase, Aurel;Oniscu, Corneliu;
Institution: Center for Drug Evaluation, Antibiotice S.A., Iasi, Romania. [email protected]
Shortcut link to this study:
Liquid chromatography (LC) coupled with mass spectrometry (MS) detection is one of the most powerful analytical tools for organic compound analysis. THE ADVANTAGES OF USING LC/MS METHODS OVER HPLC METHODS INCLUDE: selectivity, chromatographic integrity, peak assignment, structural information, and rapid method development. In this paper, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of bisoprolol in human plasma samples, using metoprolol as internal standard and liquid-liquid extraction procedure. The assay has proven to be sensitive, specific and reproducible, suitable to determine the bisoprolol concentration, following a single oral administration of a 10 mg bisoprolol tablet in 22 healthy volunteers, in the bioequivalence study of Bisoprolol 10 mg coated tablets, produced by Antibiotice S.A. versus Concor 10 mg, produced by Merck.
PMID: 19696905
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