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char = s;code = 115
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char = i;code = 105
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
result sql = Vitamin D receptor variants and breast cancer risk in the Polish population.
Vitamin D receptor variants and breast cancer risk in the Polish population.
char = T;code = 84
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char = ;code = 32
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char = e;code = 101
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char = ;code = 32
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char = (;code = 40
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char = 4;code = 52
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char = 8;code = 56
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char = a;code = 97
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char = d;code = 100
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char = r;code = 114
char = s;code = 115
char = 4;code = 52
char = 5;code = 53
char = 1;code = 49
char = 6;code = 54
char = 0;code = 48
char = 3;code = 51
char = 5;code = 53
char = );code = 41
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char = e;code = 101
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char = s;code = 115
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char = b;code = 98
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char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
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char = <;code = 60
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = W;code = 87
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char = I;code = 73
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char = D;code = 68
char = E;code = 69
char = P;code = 80
char = E;code = 69
char = N;code = 78
char = D;code = 68
char = E;code = 69
char = N;code = 78
char = T;code = 84
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char = S;code = 83
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char = R;code = 82
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char = E;code = 69
char = S;code = 83
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char = O;code = 79
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char = ;code = 32
char = F;code = 70
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char = M;code = 77
char = A;code = 65
char = L;code = 76
char = E;code = 69
char = ;code = 32
char = P;code = 80
char = A;code = 65
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char = I;code = 73
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = W;code = 87
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char = R;code = 82
char = E;code = 69
char = ;code = 32
char = E;code = 69
char = M;code = 77
char = P;code = 80
char = L;code = 76
char = O;code = 79
char = Y;code = 89
char = E;code = 69
char = D;code = 68
char = :;code = 58
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char = <;code = 60
char = /;code = 47
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char = >;code = 62
char = ;code = 32
char = 9;code = 57
char = 6;code = 54
char = 0;code = 48
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char = c;code = 99
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char = e;code = 101
char = c;code = 99
char = u;code = 117
char = t;code = 116
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char = v;code = 118
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = c;code = 99
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char = c;code = 99
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char = r;code = 114
char = ;code = 32
char = c;code = 99
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char = s;code = 115
char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = 8;code = 56
char = 0;code = 48
char = 0;code = 48
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char = u;code = 117
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char = l;code = 108
char = e;code = 101
char = c;code = 99
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char = d;code = 100
char = ;code = 32
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = l;code = 108
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char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = c;code = 99
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char = e;code = 101
char = s;code = 115
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char = d;code = 100
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char = u;code = 117
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char = r;code = 114
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char = t;code = 116
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char = ;code = 32
char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 5;code = 53
char = 1;code = 49
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = o;code = 111
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = f;code = 102
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char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = 9;code = 57
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char = g;code = 103
char = o;code = 111
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char = r;code = 114
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char = O;code = 79
char = R;code = 82
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char = ;code = 32
char = C;code = 67
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char = 1;code = 49
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char = e;code = 101
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char = n;code = 110
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char = r;code = 114
char = ;code = 32
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char = ;code = 32
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char = ;code = 32
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char = i;code = 105
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result sql = The aim of the study was to determine whether four VDR gene single nucleotide polymorphisms (SNPS: rs1544410, rs731236, rs10735810 and rs4516035) are associated with breast cancer risk in Polish population.

TWO INDEPENDENT SERIES OF FEMALE PATIENTS WERE EMPLOYED: 960 consecutive breast cancer cases, and 800 unselected early onset cases diagnosed under the age of 51. The control group for the consecutive breast cancer cases consisted of 960 healthy, age-matched women with a negative cancer family history. 550 healthy women, aged 51 or less, with negative cancer family history were selected as the independent controls for the early onset breast cancer cases. The frequencies of the VDR polymorphisms in the unselected cases when compared to the respective control population failed to reveal any association between the individual SNPs and disease. Examination of the group of early-onset patients, revealed an association between rs10735810 and increased breast cancer risk. Heterozygous carriers for the change had an OR = 1.73 (95% CI 1.33-2.26, P < 0.0001) and homozygous carriers OR = 2.34 (95% CI 1.71-3.21, P < 0.0001). The remaining three examined SNPs failed to show any association with disease risk. In summary, this study has identified an association between the VDR gene and early onset breast cancer risk in the Polish population.

Publication: Breast Cancer Res. Treat. 2009 Jun ;115(3)::629-33. :doi: 10.1007/s10549-008-0107-1.
Publication Date: 2009 Jun
Study Author(s): Gapska, P;Scott, R J;Serrano-Fernandez, P;Huzarski, T;Byrski, T;Kładny, J;Gronwald, J;Górski, B;Cybulski, C;Lubinski, J;Debniak, T;
Institution: Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Połabska 4, 70-115, Szczecin, Poland.
Shortcut link to this study:
The aim of the study was to determine whether four VDR gene single nucleotide polymorphisms (SNPS: rs1544410, rs731236, rs10735810 and rs4516035) are associated with breast cancer risk in Polish population.

TWO INDEPENDENT SERIES OF FEMALE PATIENTS WERE EMPLOYED: 960 consecutive breast cancer cases, and 800 unselected early onset cases diagnosed under the age of 51. The control group for the consecutive breast cancer cases consisted of 960 healthy, age-matched women with a negative cancer family history. 550 healthy women, aged 51 or less, with negative cancer family history were selected as the independent controls for the early onset breast cancer cases. The frequencies of the VDR polymorphisms in the unselected cases when compared to the respective control population failed to reveal any association between the individual SNPs and disease. Examination of the group of early-onset patients, revealed an association between rs10735810 and increased breast cancer risk. Heterozygous carriers for the change had an OR = 1.73 (95% CI 1.33-2.26, P < 0.0001) and homozygous carriers OR = 2.34 (95% CI 1.71-3.21, P < 0.0001). The remaining three examined SNPs failed to show any association with disease risk. In summary, this study has identified an association between the VDR gene and early onset breast cancer risk in the Polish population.
PMID: 18587672

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