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char = t;code = 116
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char = h;code = 104
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char = t;code = 116
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char = 8;code = 56
char = F;code = 70
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char = o;code = 111
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char = n;code = 110
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char = P;code = 80
char = E;code = 69
char = T;code = 84
char = -;code = 45
char = C;code = 67
char = T;code = 84
char = ;code = 32
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char = e;code = 101
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char = e;code = 101
char = c;code = 99
char = t;code = 116
char = e;code = 101
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char = ;code = 32
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char = m;code = 109
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char = l;code = 108
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = e;code = 101
char = o;code = 111
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char = s;code = 115
char = ;code = 32
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char = n;code = 110
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char = e;code = 101
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char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = .;code = 46
result sql = Dose-escalation using intensity-modulated radiotherapy for prostate cancer--evaluation of the dose distribution with and without 18F-choline PET-CT detected simultaneous integrated boost.
Dose-escalation using intensity-modulated radiotherapy for prostate cancer--evaluation of the dose distribution with and without 18F-choline PET-CT detected simultaneous integrated boost.
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char = m;code = 109
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char = o;code = 111
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char = b;code = 98
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char = e;code = 101
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char = ;code = 32
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char = e;code = 101
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char = d;code = 100
char = d;code = 100
char = e;code = 101
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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result sql = BACKGROUND AND PURPOSE : The aim of the study was to evaluate the impact of a dose escalation to an (18)F-choline PET-CT defined simultaneous integrated boost (IB) on the dose distribution and changes of the equivalent uniform dose (EUD).

MATERIALS AND METHODS : PET-CT was performed in 12 consecutive patients for treatment planning. An intraprostatic lesion was defined by a tumour-to-background uptake value ratio >2 (GTV(PET)). Dose escalation was focused only on the intraprostatic lesion. Two comparisons were evaluated: whole prostate irradiation to 76 Gy+/-boost to 80 Gy (C1) and whole prostate irradiation to 66.6 Gy+/-boost to 83.25 Gy (C2).

RESULTS : PTV/GTV(PET)+margins were covered by a mean EUD of 75.9/76.1 Gy vs. 77.1/80.1 Gy (C1) and 66.5/66.2 Gy vs. 71.1/82.9 Gy (C2) (p<0.01, respectively). Concerning the organs at risk, EUD increased slightly with an additional boost (mean EUD for bladder: C1 53.2 Gy vs. 53.8 Gy; C2 43.0 Gy vs. 45.1 Gy; for rectum: C1 52.0 Gy vs. 52.6 Gy; C2 43.0 Gy vs. 45.4 Gy; p<0.01, respectively). The distance to the organs at risk had a significant impact on the respective maximum doses in the treatment plans with IB.

CONCLUSIONS : Treatment planning with IB allows an individually adapted dose escalation. The therapeutic ratio can be improved by a considerable dose escalation to the macroscopic tumour, but only minor EUD changes to the bladder and rectum.

Publication: Radiother Oncol 2009 Nov ;93(2)::213-9. :doi: 10.1016/j.radonc.2009.07.014.
Publication Date: 2009 Nov
Study Author(s): Pinkawa, Michael;Attieh, Charbel;Piroth, Marc D;Holy, Richard;Nussen, Sandra;Klotz, Jens;Hawickhorst, Robert;Schäfer, Wolfgang;Eble, Michael J;
Institution: Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany. [email protected]
Shortcut link to this study:
BACKGROUND AND PURPOSE : The aim of the study was to evaluate the impact of a dose escalation to an (18)F-choline PET-CT defined simultaneous integrated boost (IB) on the dose distribution and changes of the equivalent uniform dose (EUD).

MATERIALS AND METHODS : PET-CT was performed in 12 consecutive patients for treatment planning. An intraprostatic lesion was defined by a tumour-to-background uptake value ratio >2 (GTV(PET)). Dose escalation was focused only on the intraprostatic lesion. Two comparisons were evaluated: whole prostate irradiation to 76 Gy+/-boost to 80 Gy (C1) and whole prostate irradiation to 66.6 Gy+/-boost to 83.25 Gy (C2).

RESULTS : PTV/GTV(PET)+margins were covered by a mean EUD of 75.9/76.1 Gy vs. 77.1/80.1 Gy (C1) and 66.5/66.2 Gy vs. 71.1/82.9 Gy (C2) (p<0.01, respectively). Concerning the organs at risk, EUD increased slightly with an additional boost (mean EUD for bladder: C1 53.2 Gy vs. 53.8 Gy; C2 43.0 Gy vs. 45.1 Gy; for rectum: C1 52.0 Gy vs. 52.6 Gy; C2 43.0 Gy vs. 45.4 Gy; p<0.01, respectively). The distance to the organs at risk had a significant impact on the respective maximum doses in the treatment plans with IB.

CONCLUSIONS : Treatment planning with IB allows an individually adapted dose escalation. The therapeutic ratio can be improved by a considerable dose escalation to the macroscopic tumour, but only minor EUD changes to the bladder and rectum.
PMID: 19717197

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