char = A;code = 65
Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells.char = T;code = 84
Publication: Food Chem. Toxicol. 2009 Mar ;47(3)::536-9. :doi: 10.1016/j.fct.2008.12.006.
Publication Date: 2009 Mar
Study Author(s): Siddique, Yasir Hasan;Afzal, Mohammad;
Institution: Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P. 202 002, India.
[email protected]
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The antigenotoxic effect of apigenin was studied against the genotoxic damage induced by mitomycin C on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Apigenin was studied at three different doses i.e. 10, 20 and 40 mg/kg b.w. and was found to be non-genotoxic at all the above three doses. Mitomycin C at 2 mg/kg b.w. was given along with the 10, 20 and 40 mg/kg bw of apigenin. A significant decrease in SCEs and CAs was observed, suggesting a protective role of apigenin against the genotoxicity of mitomycin C on mice bone marrow cells.
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