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result sql = The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population.
The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population.
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result sql = In the first case-control study on pancreatic cancer conducted on 253 cases and 403 controls in the Czech Republic we observed that the GSTP1-codon 105 Val variant allele and the GSTT1-null genotype were associated with an elevated risk for pancreatic cancer (OR = 1.38; 95%CI = 0.96-1.97 and OR = 1.56; 95%CI = 0.93-2.61, respectively). Combination of GSTT1-null and GSTP1-codon 105 Val variants further increased the risk for pancreatic cancer (OR = 2.50; 95%CI = 1.20-5.20). In conclusion, this study suggests population-specific associations of polymorphisms in key biotransformation genes with elevated risk for pancreatic cancer.

Publication: Mutat. Res. 2009 Nov-Dec ;680(1-2)::78-81. :doi: 10.1016/j.mrgentox.2009.09.005.
Publication Date: 2009 Nov-Dec
Study Author(s): Vrana, D;Pikhart, H;Mohelnikova-Duchonova, B;Holcatova, I;Strnad, R;Slamova, A;Schejbalova, M;Ryska, M;Susova, S;Soucek, P;
Institution: Toxicogenomics Unit, National Institute of Public Health, Prague 10, 100 42, Czech Republic.
Shortcut link to this study:
In the first case-control study on pancreatic cancer conducted on 253 cases and 403 controls in the Czech Republic we observed that the GSTP1-codon 105 Val variant allele and the GSTT1-null genotype were associated with an elevated risk for pancreatic cancer (OR = 1.38; 95%CI = 0.96-1.97 and OR = 1.56; 95%CI = 0.93-2.61, respectively). Combination of GSTT1-null and GSTP1-codon 105 Val variants further increased the risk for pancreatic cancer (OR = 2.50; 95%CI = 1.20-5.20). In conclusion, this study suggests population-specific associations of polymorphisms in key biotransformation genes with elevated risk for pancreatic cancer.
PMID: 19786118

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