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char = x;code = 120
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char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = P;code = 80
char = I;code = 73
char = K;code = 75
char = 3;code = 51
char = C;code = 67
char = A;code = 65
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = K;code = 75
char = R;code = 82
char = A;code = 65
char = S;code = 83
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char = m;code = 109
char = u;code = 117
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char = a;code = 97
char = t;code = 116
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char = o;code = 111
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char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = c;code = 99
char = o;code = 111
char = l;code = 108
char = o;code = 111
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char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
result sql = Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer.
Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer.
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char = s;code = 115
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char = c;code = 99
char = e;code = 101
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char = ;code = 32
char = (;code = 40
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char = D;code = 68
char = R;code = 82
char = );code = 41
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = t;code = 116
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char = a;code = 97
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char = c;code = 99
char = r;code = 114
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char = t;code = 116
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char = o;code = 111
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char = a;code = 97
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char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = y;code = 121
char = s;code = 115
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char = a;code = 97
char = n;code = 110
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char = i;code = 105
char = m;code = 109
char = p;code = 112
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char = r;code = 114
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char = u;code = 117
char = l;code = 108
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char = f;code = 102
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char = t;code = 116
char = i;code = 105
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = o;code = 111
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char = p;code = 112
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = ;code = 32
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char = i;code = 105
char = n;code = 110
char = k;code = 107
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char = b;code = 98
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char = w;code = 119
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char = e;code = 101
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char = V;code = 86
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char = R;code = 82
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char = k;code = 107
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char = (;code = 40
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char = d;code = 100
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char = i;code = 105
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char = o;code = 111
char = l;code = 108
char = ;code = 32
char = 3;code = 51
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char = k;code = 107
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char = e;code = 101
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char = (;code = 40
char = P;code = 80
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char = );code = 41
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char = K;code = 75
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char = w;code = 119
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char = h;code = 104
char = a;code = 97
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char = b;code = 98
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char = e;code = 101
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char = s;code = 115
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char = g;code = 103
char = g;code = 103
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char = t;code = 116
char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = H;code = 72
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char = v;code = 118
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char = ,;code = 44
char = ;code = 32
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char = p;code = 112
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char = c;code = 99
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char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = V;code = 86
char = D;code = 68
char = R;code = 82
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
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char = n;code = 110
char = ;code = 32
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char = ;code = 32
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char = s;code = 115
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char = e;code = 101
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char = i;code = 105
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char = w;code = 119
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char = h;code = 104
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char = P;code = 80
char = I;code = 73
char = K;code = 75
char = 3;code = 51
char = C;code = 67
char = A;code = 65
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char = o;code = 111
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char = K;code = 75
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char = S;code = 83
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = m;code = 109
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char = g;code = 103
char = ;code = 32
char = 6;code = 54
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char = C;code = 67
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char = A;code = 65
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char = 1;code = 49
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char = N;code = 78
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char = O;code = 79
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char = 1;code = 49
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char = a;code = 97
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char = 1;code = 49
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char = s;code = 115
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = a;code = 97
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char = s;code = 115
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char = a;code = 97
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = K;code = 75
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char = A;code = 65
char = S;code = 83
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char = m;code = 109
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
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char = d;code = 100
char = s;code = 115
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char = i;code = 105
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char = ;code = 32
char = 1;code = 49
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char = 5;code = 53
char = 5;code = 53
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char = ;code = 32
char = 9;code = 57
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char = %;code = 37
char = ;code = 32
char = c;code = 99
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char = c;code = 99
char = e;code = 101
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char = i;code = 105
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char = a;code = 97
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char = ,;code = 44
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 1;code = 49
char = 1;code = 49
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char = 2;code = 50
char = .;code = 46
char = 1;code = 49
char = 6;code = 54
char = );code = 41
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = P;code = 80
char = I;code = 73
char = K;code = 75
char = 3;code = 51
char = C;code = 67
char = A;code = 65
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char = m;code = 109
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char = a;code = 97
char = t;code = 116
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char = s;code = 115
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char = 2;code = 50
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char = 1;code = 49
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char = %;code = 37
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char = ;code = 32
char = 1;code = 49
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char = 4;code = 52
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char = b;code = 98
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char = V;code = 86
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char = w;code = 119
char = a;code = 97
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char = S;code = 83
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char = L;code = 76
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char = F;code = 70
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result sql = Vitamin D is associated with decreased risks of various cancers, including colon cancer. The vitamin D receptor (VDR) is a transcription factor, which plays an important role in cellular differentiation and inhibition of proliferation. A link between VDR and the RAS-mitogen-activated protein kinase (MAPK) or phosphatidylinositol 3-kinase (PI3K)-AKT pathway has been suggested. However, the prognostic role of VDR expression or its relationship with PIK3CA or KRAS mutation remains uncertain. Among 619 colorectal cancers in two prospective cohort studies, 233 (38%) tumors showed VDR overexpression by immunohistochemistry. We analyzed for PIK3CA and KRAS mutations and LINE-1 methylation by Pyrosequencing, microsatellite instability (MSI), and DNA methylation (epigenetic changes) in eight CpG island methylator phenotype (CIMP)-specific promoters [CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1] by MethyLight (real-time PCR). VDR overexpression was significantly associated with KRAS mutation (odds ratio, 1.55; 95% confidence interval, 1.11-2.16) and PIK3CA mutation (odds ratio, 2.17; 95% confidence interval, 1.36-3.47), both of which persisted in multivariate logistic regression analysis. VDR was not independently associated with body mass index, family history of colorectal cancer, tumor location (colon versus rectum), stage, tumor grade, signet ring cells, CIMP, MSI, LINE-1 hypomethylation, BRAF, p53, p21, beta-catenin, or cyclooxygenase-2. VDR expression was not significantly related with patient survival, prognosis, or clinical outcome. In conclusion, VDR overexpression in colorectal cancer is independently associated with PIK3CA and KRAS mutations. Our data support potential interactions between the VDR, RAS-MAPK and PI3K-AKT pathways, and possible influence by KRAS or PIK3CA mutation on therapy or chemoprevention targeting VDR.

Publication: Cancer Epidemiol. Biomarkers Prev. 2009 Oct ;18(10)::2765-72. :doi: 10.1158/1055-9965.EPI-09-0490.
Publication Date: 2009 Oct
Study Author(s): Kure, Shoko;Nosho, Katsuhiko;Baba, Yoshifumi;Irahara, Natsumi;Shima, Kaori;Ng, Kimmie;Meyerhardt, Jeffrey A;Giovannucci, Edward L;Fuchs, Charles S;Ogino, Shuji;
Institution: Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.
Shortcut link to this study:
Vitamin D is associated with decreased risks of various cancers, including colon cancer. The vitamin D receptor (VDR) is a transcription factor, which plays an important role in cellular differentiation and inhibition of proliferation. A link between VDR and the RAS-mitogen-activated protein kinase (MAPK) or phosphatidylinositol 3-kinase (PI3K)-AKT pathway has been suggested. However, the prognostic role of VDR expression or its relationship with PIK3CA or KRAS mutation remains uncertain. Among 619 colorectal cancers in two prospective cohort studies, 233 (38%) tumors showed VDR overexpression by immunohistochemistry. We analyzed for PIK3CA and KRAS mutations and LINE-1 methylation by Pyrosequencing, microsatellite instability (MSI), and DNA methylation (epigenetic changes) in eight CpG island methylator phenotype (CIMP)-specific promoters [CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1] by MethyLight (real-time PCR). VDR overexpression was significantly associated with KRAS mutation (odds ratio, 1.55; 95% confidence interval, 1.11-2.16) and PIK3CA mutation (odds ratio, 2.17; 95% confidence interval, 1.36-3.47), both of which persisted in multivariate logistic regression analysis. VDR was not independently associated with body mass index, family history of colorectal cancer, tumor location (colon versus rectum), stage, tumor grade, signet ring cells, CIMP, MSI, LINE-1 hypomethylation, BRAF, p53, p21, beta-catenin, or cyclooxygenase-2. VDR expression was not significantly related with patient survival, prognosis, or clinical outcome. In conclusion, VDR overexpression in colorectal cancer is independently associated with PIK3CA and KRAS mutations. Our data support potential interactions between the VDR, RAS-MAPK and PI3K-AKT pathways, and possible influence by KRAS or PIK3CA mutation on therapy or chemoprevention targeting VDR.
PMID: 19789368

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