char = S;code = 83
Synthesis and antiprotozoal activity of novel 1-methylbenzimidazole derivatives.char = I;code = 73
Publication: Bioorg. Med. Chem. 2009 Feb 15 ;17(4)::1724-30. :doi: 10.1016/j.bmc.2008.12.059.
In this paper are reported the synthesis and antiprotozoal activity in vitro of 24 1-methylbenzimidazole derivatives (13-36) substituted at position 2 with aminocarbonyl, N-methylaminocarbonyl, N,N-dimethylaminocarbonyl, ethoxycarbonyl, 1-hydroxyethyl and acetyl groups, some of them with chlorine atoms at the benzenoid ring. Compounds 13-36 were more active than metronidazole, the choice drug against Giardia intestinalis and most of them against Trichomonas vaginalis. The most active group of compounds for both parasites was that with a 2-ethoxycarbonyl group (16, 22, 28, 34), independently of the substitution pattern at the benzenoid ring.
PMID: 19186059
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