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char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = :;code = 58
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char = o;code = 111
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char = t;code = 116
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = I;code = 73
char = B;code = 66
char = S;code = 83
char = .;code = 46
result sql = Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS.
Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS.
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char = i;code = 105
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char = N;code = 78
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char = b;code = 98
char = e;code = 101
char = r;code = 114
char = s;code = 115
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char = ;code = 32
char = c;code = 99
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char = t;code = 116
char = r;code = 114
char = a;code = 97
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char = t;code = 116
char = i;code = 105
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char = s;code = 115
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char = a;code = 97
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char = ;code = 32
char = A;code = 65
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char = C;code = 67
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = r;code = 114
char = s;code = 115
char = t;code = 116
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char = t;code = 116
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = f;code = 102
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char = u;code = 117
char = r;code = 114
char = t;code = 116
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char = a;code = 97
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char = t;code = 116
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char = l;code = 108
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char = i;code = 105
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char = h;code = 104
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char = a;code = 97
char = l;code = 108
char = t;code = 116
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char = <;code = 60
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char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
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char = a;code = 97
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char = n;code = 110
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char = b;code = 98
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char = r;code = 114
char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = c;code = 99
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char = t;code = 116
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char = t;code = 116
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char = s;code = 115
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char = i;code = 105
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = s;code = 115
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char = b;code = 98
char = j;code = 106
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char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = s;code = 115
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char = m;code = 109
char = i;code = 105
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = t;code = 116
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char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = t;code = 116
char = r;code = 114
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char = s;code = 115
char = .;code = 46
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char = M;code = 77
char = e;code = 101
char = a;code = 97
char = n;code = 110
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char = A;code = 65
char = U;code = 85
char = C;code = 67
char = s;code = 115
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = t;code = 116
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char = (;code = 40
char = P;code = 80
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = m;code = 109
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char = d;code = 100
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = S;code = 83
char = T;code = 84
char = C;code = 67
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 4;code = 52
char = );code = 41
char = ;code = 32
char = b;code = 98
char = u;code = 117
char = t;code = 116
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char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = S;code = 83
char = T;code = 84
char = C;code = 67
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = N;code = 78
char = S;code = 83
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char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
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char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = h;code = 104
char = e;code = 101
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = h;code = 104
char = y;code = 121
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char = s;code = 115
char = u;code = 117
char = b;code = 98
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = I;code = 73
char = B;code = 66
char = S;code = 83
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = g;code = 103
char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = r;code = 114
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char = m;code = 109
char = e;code = 101
char = a;code = 97
char = n;code = 110
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char = n;code = 110
char = u;code = 117
char = m;code = 109
char = b;code = 98
char = e;code = 101
char = r;code = 114
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = =;code = 61
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char = 0;code = 48
char = .;code = 46
char = 0;code = 48
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char = ;code = 32
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char = A;code = 65
char = U;code = 85
char = C;code = 67
char = s;code = 115
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char = (;code = 40
char = P;code = 80
char = ;code = 32
char = =;code = 61
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char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
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char = e;code = 101
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char = ;code = 32
char = t;code = 116
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char = a;code = 97
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = .;code = 46
char = ;code = 32
char = N;code = 78
char = u;code = 117
char = m;code = 109
char = b;code = 98
char = e;code = 101
char = r;code = 114
char = s;code = 115
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char = ;code = 32
char = c;code = 99
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char = t;code = 116
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char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
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char = r;code = 114
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char = m;code = 109
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char = f;code = 102
char = i;code = 105
char = r;code = 114
char = s;code = 115
char = t;code = 116
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char = t;code = 116
char = o;code = 111
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char = o;code = 111
char = u;code = 117
char = r;code = 114
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char = h;code = 104
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char = i;code = 105
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char = e;code = 101
char = s;code = 115
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char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = S;code = 83
char = T;code = 84
char = C;code = 67
char = ,;code = 44
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char = C;code = 67
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char = I;code = 73
char = B;code = 66
char = S;code = 83
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = f;code = 102
char = u;code = 117
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char = a;code = 97
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char = c;code = 99
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char = C;code = 67
char = s;code = 115
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char = i;code = 105
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char = a;code = 97
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char = f;code = 102
char = r;code = 114
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char = m;code = 109
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char = t;code = 116
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char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = r;code = 114
char = s;code = 115
char = t;code = 116
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char = t;code = 116
char = o;code = 111
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char = f;code = 102
char = o;code = 111
char = u;code = 117
char = r;code = 114
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char = l;code = 108
char = e;code = 101
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char = a;code = 97
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char = l;code = 108
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char = r;code = 114
char = o;code = 111
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char = p;code = 112
char = s;code = 115
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char = (;code = 40
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char = l;code = 108
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char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
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char = .;code = 46
char = 0;code = 48
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char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = c;code = 99
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char = n;code = 110
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char = s;code = 115
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char = t;code = 116
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char = t;code = 116
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char = y;code = 121
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = I;code = 73
char = B;code = 66
char = S;code = 83
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = f;code = 102
char = i;code = 105
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char = i;code = 105
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = z;code = 122
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char = d;code = 100
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char = f;code = 102
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char = f;code = 102
char = f;code = 102
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char = s;code = 115
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char = t;code = 116
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = u;code = 117
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char = y;code = 121
char = p;code = 112
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result sql = Relationships of regional colonic motility to transit in health, constipation, and constipation-predominant irritable bowel syndrome (C-IBS) are poorly characterized. This study aimed to 1) characterize regional differences in colon pressure, 2) relate motor differences in constipation to colon transit, and 3) quantify the role of IBS in altered contractility with constipation. Colon pH and pressure were measured by wireless capsules in 53 healthy and 36 constipated subjects. Numbers of contractions >25 mmHg and areas under curves (AUC) were calculated for colon transit quartiles by time. Constipation was classified as normal transit (<59 h), moderate slow transit (STC) (59-100 h), and severe STC (>100 h). Twelve out of 36 constipated subjects had C-IBS; 24 had functional constipation. Numbers of contractions and AUCs increased from the first to the fourth quartile in health (P < 0.0001). Mean numbers of contractions in constipated subjects were similar to controls. Mean AUCs with normal transit (P = 0.01) and moderate STC (P = 0.004) but not severe STC (P = NS) were higher than healthy subjects. IBS was associated with greater mean numbers of contractions (P = 0.05) and AUCs (P = 0.0006) vs. controls independent of transit. Numbers of contractions increased from the first to fourth quartiles in moderate STC, C-IBS, and functional constipation; AUCs increased from the first to fourth quartiles in all groups (all P < 0.05). In conclusion, colon pressure activity is greater distally than proximally in health. Constipated patients with normal or moderately delayed transit show increased motor activity that is partly explained by IBS. These findings emphasize differential effects on transit and motility in different constipation subtypes.

Publication: Am. J. Physiol. Gastrointest. Liver Physiol. 2009 Dec ;297(6)::G1107-14. :doi: 10.1152/ajpgi.00136.2009.
Publication Date: 2009 Dec
Study Author(s): Hasler, William L;Saad, Richard J;Rao, Satish S;Wilding, Gregory E;Parkman, Henry P;Koch, Kenneth L;McCallum, Richard W;Kuo, Braden;Sarosiek, Irene;Sitrin, Michael D;Semler, John R;Chey, William D;
Institution: University of Michigan Health System, Ann Arbor, Michigan, USA. [email protected]
Shortcut link to this study:
Relationships of regional colonic motility to transit in health, constipation, and constipation-predominant irritable bowel syndrome (C-IBS) are poorly characterized. This study aimed to 1) characterize regional differences in colon pressure, 2) relate motor differences in constipation to colon transit, and 3) quantify the role of IBS in altered contractility with constipation. Colon pH and pressure were measured by wireless capsules in 53 healthy and 36 constipated subjects. Numbers of contractions >25 mmHg and areas under curves (AUC) were calculated for colon transit quartiles by time. Constipation was classified as normal transit (<59 h), moderate slow transit (STC) (59-100 h), and severe STC (>100 h). Twelve out of 36 constipated subjects had C-IBS; 24 had functional constipation. Numbers of contractions and AUCs increased from the first to the fourth quartile in health (P < 0.0001). Mean numbers of contractions in constipated subjects were similar to controls. Mean AUCs with normal transit (P = 0.01) and moderate STC (P = 0.004) but not severe STC (P = NS) were higher than healthy subjects. IBS was associated with greater mean numbers of contractions (P = 0.05) and AUCs (P = 0.0006) vs. controls independent of transit. Numbers of contractions increased from the first to fourth quartiles in moderate STC, C-IBS, and functional constipation; AUCs increased from the first to fourth quartiles in all groups (all P < 0.05). In conclusion, colon pressure activity is greater distally than proximally in health. Constipated patients with normal or moderately delayed transit show increased motor activity that is partly explained by IBS. These findings emphasize differential effects on transit and motility in different constipation subtypes.
PMID: 19808653

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