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char = .;code = 46
result sql = The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life.
The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life.
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = p;code = 112
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char = t;code = 116
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char = e;code = 101
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char = f;code = 102
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char = r;code = 114
char = s;code = 115
char = t;code = 116
char = ,;code = 44
char = ;code = 32
char = A;code = 65
char = L;code = 76
char = A;code = 65
char = ;code = 32
char = a;code = 97
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char = ;code = 32
char = G;code = 71
char = L;code = 76
char = A;code = 65
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ,;code = 44
char = ;code = 32
char = (;code = 40
char = n;code = 110
char = ;code = 32
char = =;code = 61
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char = 1;code = 49
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char = 1;code = 49
char = );code = 41
char = ;code = 32
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = i;code = 105
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char = e;code = 101
char = d;code = 100
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char = a;code = 97
char = l;code = 108
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char = d;code = 100
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 6;code = 54
char = 0;code = 48
char = 0;code = 48
char = ;code = 32
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char = g;code = 103
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = l;code = 108
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char = p;code = 112
char = o;code = 111
char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
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char = (;code = 40
char = A;code = 65
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char = A;code = 65
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = 3;code = 51
char = 6;code = 54
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char = m;code = 109
char = g;code = 103
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char = o;code = 111
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char = ;code = 32
char = g;code = 103
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
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char = l;code = 108
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = (;code = 40
char = G;code = 71
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char = A;code = 65
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = r;code = 114
char = e;code = 101
char = h;code = 104
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = m;code = 109
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = s;code = 115
char = i;code = 105
char = x;code = 120
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = c;code = 99
char = o;code = 111
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char = d;code = 100
char = ;code = 32
char = (;code = 40
char = n;code = 110
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = l;code = 108
char = y;code = 121
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char = r;code = 114
char = e;code = 101
char = h;code = 104
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = m;code = 109
char = .;code = 46
char = ;code = 32
char = P;code = 80
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = r;code = 114
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = P;code = 80
char = h;code = 104
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = M;code = 77
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = R;code = 82
char = e;code = 101
char = h;code = 104
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = y;code = 121
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char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = w;code = 119
char = e;code = 101
char = n;code = 110
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char = ;code = 32
char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = c;code = 99
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char = e;code = 101
char = x;code = 120
char = a;code = 97
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char = n;code = 110
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = p;code = 112
char = r;code = 114
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char = m;code = 109
char = a;code = 97
char = r;code = 114
char = y;code = 121
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char = t;code = 116
char = c;code = 99
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char = e;code = 101
char = s;code = 115
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char = e;code = 101
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char = r;code = 114
char = e;code = 101
char = c;code = 99
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char = d;code = 100
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char = g;code = 103
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char = t;code = 116
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char = a;code = 97
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char = t;code = 116
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char = o;code = 111
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char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
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char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = r;code = 114
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char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
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char = ,;code = 44
char = ;code = 32
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char = x;code = 120
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char = w;code = 119
char = e;code = 101
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char = k;code = 107
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char = t;code = 116
char = 3;code = 51
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = s;code = 115
char = a;code = 97
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char = e;code = 101
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char = h;code = 104
char = a;code = 97
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char = b;code = 98
char = e;code = 101
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = e;code = 101
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char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = s;code = 115
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = ;code = 32
char = V;code = 86
char = A;code = 65
char = S;code = 83
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char = s;code = 115
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = ,;code = 44
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char = S;code = 83
char = F;code = 70
char = -;code = 45
char = 3;code = 51
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char = ,;code = 44
char = ;code = 32
char = O;code = 79
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char = e;code = 101
char = s;code = 115
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char = r;code = 114
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char = w;code = 119
char = ;code = 32
char = B;code = 66
char = a;code = 97
char = c;code = 99
char = k;code = 107
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char = P;code = 80
char = a;code = 97
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char = n;code = 110
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char = D;code = 68
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char = a;code = 97
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char = a;code = 97
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char = f;code = 102
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char = c;code = 99
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char = p;code = 112
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char = L;code = 76
char = A;code = 65
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char = a;code = 97
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char = g;code = 103
char = r;code = 114
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char = e;code = 101
char = s;code = 115
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char = a;code = 97
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char = b;code = 98
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char = d;code = 100
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char = n;code = 110
char = g;code = 103
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char = p;code = 112
char = a;code = 97
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char = ,;code = 44
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char = a;code = 97
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char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = V;code = 86
char = A;code = 65
char = S;code = 83
char = ;code = 32
char = (;code = 40
char = V;code = 86
char = i;code = 105
char = s;code = 115
char = u;code = 117
char = a;code = 97
char = l;code = 108
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char = A;code = 65
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char = a;code = 97
char = l;code = 108
char = o;code = 111
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char = u;code = 117
char = e;code = 101
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char = S;code = 83
char = c;code = 99
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result sql = The aim of this trial was to evaluate the effects of alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) and the beneficial effect of physical exercise on positive sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict. Often these painful syndromes after the acute event, tend to recurr becoming subacute or chronic syndromes that become for the period of interest disabiling is an event very important in these cases proper prevention, based on a maintenance drug therapy and the strengthening exercises of paravertebral muscles, flexibility exercises on the spine and when needed on the reduction of body weight. In this Observational Cohort, two-arm trial, 203 patients were enrolled and divided into two groups, the first, ALA and GLA group, (n = 101) received oral dose of 600 mg of alpha-lipoic acid (ALA) and 360 mg of gamma-linolenic acid (GLA) and a rehabilitation program for six weeks, the second (n = 102) treated with only rehabilitation program. Patients were recruited at the centre of Physical Medicine and Rehabilitation, they underwent a physiatric examination at the primary outcome (t0) and secondary outcomes were recorded at monitoring visits scheduled at two weeks = t1, four weeks = t2, six weeks = t3, and at the same has been administered the following scale: VAS scale, SF-36, Oswestry Low Back Pain Disability Questionnaire, Aberdeen Back Pain Scale (ABPS), Revised Leeds Disability Questionnaire (LDQ), Roland and Morris Disability Questionnaire. Significant improvements was noted in the ALA and GLA group for paresthesia, stabbing and burning pain, as showed by VAS (Visual Analogue Scale), Oswestry Low Back Pain Disability Questionnaire, Aberdeen Low Back Pain Scale; also, improvements of quality of life has been noted, in the same group, as showed by SF-36, LDQ (Revised Leeds Disability Questionnaire), Roland and Morris disability questionnaire. All these outcome measure showed statistically significant decreases. Oral treatment with alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) for six weeks in synergy with rehabilitation therapy improved neuropathic symptoms and deficits in patients with radicular neuropathy.

Publication: Int J Immunopathol Pharmacol 2009 Jul-Sep ;22(3 Suppl)::45-50.
Publication Date: 2009 Jul-Sep
Study Author(s): Ranieri, M;Sciuscio, M;Cortese, A M;Santamato, A;Di Teo, L;Ianieri, G;Bellomo, R G;Stasi, M;Megna, M;
Institution: Physical Medicine and Rehabilitation Unit, Neurological and Psychiatric Sciences Department, Aldo Moro University, Bari 70124, Italy. [email protected]
Shortcut link to this study:
The aim of this trial was to evaluate the effects of alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) and the beneficial effect of physical exercise on positive sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict. Often these painful syndromes after the acute event, tend to recurr becoming subacute or chronic syndromes that become for the period of interest disabiling is an event very important in these cases proper prevention, based on a maintenance drug therapy and the strengthening exercises of paravertebral muscles, flexibility exercises on the spine and when needed on the reduction of body weight. In this Observational Cohort, two-arm trial, 203 patients were enrolled and divided into two groups, the first, ALA and GLA group, (n = 101) received oral dose of 600 mg of alpha-lipoic acid (ALA) and 360 mg of gamma-linolenic acid (GLA) and a rehabilitation program for six weeks, the second (n = 102) treated with only rehabilitation program. Patients were recruited at the centre of Physical Medicine and Rehabilitation, they underwent a physiatric examination at the primary outcome (t0) and secondary outcomes were recorded at monitoring visits scheduled at two weeks = t1, four weeks = t2, six weeks = t3, and at the same has been administered the following scale: VAS scale, SF-36, Oswestry Low Back Pain Disability Questionnaire, Aberdeen Back Pain Scale (ABPS), Revised Leeds Disability Questionnaire (LDQ), Roland and Morris Disability Questionnaire. Significant improvements was noted in the ALA and GLA group for paresthesia, stabbing and burning pain, as showed by VAS (Visual Analogue Scale), Oswestry Low Back Pain Disability Questionnaire, Aberdeen Low Back Pain Scale; also, improvements of quality of life has been noted, in the same group, as showed by SF-36, LDQ (Revised Leeds Disability Questionnaire), Roland and Morris disability questionnaire. All these outcome measure showed statistically significant decreases. Oral treatment with alpha-lipoic acid (ALA) and gamma-linolenic acid (GLA) for six weeks in synergy with rehabilitation therapy improved neuropathic symptoms and deficits in patients with radicular neuropathy.
PMID: 19887043

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