|
|
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result sql = An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta.
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta.char = I;code = 73
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char = l;code = 108
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char = o;code = 111
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char = ;code = 32
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char = u;code = 117
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char = l;code = 108
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char = p;code = 112
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char = d;code = 100
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char = t;code = 116
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char = o;code = 111
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char = c;code = 99
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char = l;code = 108
char = s;code = 115
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char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = g;code = 103
char = e;code = 101
char = n;code = 110
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char = s;code = 115
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = i;code = 105
char = z;code = 122
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = h;code = 104
char = a;code = 97
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char = s;code = 115
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char = t;code = 116
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = G;code = 71
char = S;code = 83
char = K;code = 75
char = 3;code = 51
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = a;code = 97
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char = t;code = 116
char = a;code = 97
char = r;code = 114
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char = e;code = 101
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = f;code = 102
char = e;code = 101
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = G;code = 71
char = S;code = 83
char = K;code = 75
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char = e;code = 101
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char = l;code = 108
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char = l;code = 108
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = G;code = 71
char = S;code = 83
char = K;code = 75
char = 3;code = 51
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = w;code = 119
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char = a;code = 97
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char = a;code = 97
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char = e;code = 101
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char = r;code = 114
char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = G;code = 71
char = S;code = 83
char = K;code = 75
char = 3;code = 51
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = .;code = 46
char = <;code = 60
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result sql = Improvement in the outcome of cancer patients who are refractory to currently available treatments relies on the development of target-directed therapies. One group of molecular targets with potential clinical relevance is a set of protein tyrosine kinases encoded mostly by proto-oncogenes and that are frequently deregulated in cancer. Glycogen synthase kinase 3beta (GSK3beta), a serine/threonine protein kinase, has emerged as a therapeutic target for common chronic diseases including type 2 diabetes mellitus, neurodegenerative disorders, inflammation and osteoporosis. This is based on its currently known functions and primary pathologic causalities. GSK3beta has well characterized roles in the regulation of gene transcription and in oncogenic signaling. We have shown that deregulated GSK3beta promotes gastrointestinal, pancreatic and liver cancers and glioblastomas. Furthermore, we have demonstrated that inhibition of GSK3beta attenuates cell survival and proliferation, induces cell senescence and apoptosis and sensitizes tumor cells to chemotherapeutic agents and ionizing radiation. This has led us to propose GSK3beta as a potential therapeutic target in cancer. The anti-tumor effects of GSK3beta inhibition are mediated by changes in the expression and phosphorylation of molecules critical to the regulation of cell cycling, proliferation and apoptosis and underlie the pathological role for GSK3beta in cancer. Investigation of the mechanisms responsible for deregulation of GSK3beta and the consequent downstream pathologic effects in cancer cells has shed light on the molecular pathways leading to tumorigenesis. This will allow exploration of novel therapeutic strategies for cancer that target aberrant GSK3beta.
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result sql = An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta.
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char = l;code = 108
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char = G;code = 71
char = S;code = 83
char = K;code = 75
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char = I;code = 73
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char = .;code = 46
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char = T;code = 84
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result sql = Improvement in the outcome of cancer patients who are refractory to currently available treatments relies on the development of target-directed therapies. One group of molecular targets with potential clinical relevance is a set of protein tyrosine kinases encoded mostly by proto-oncogenes and that are frequently deregulated in cancer. Glycogen synthase kinase 3beta (GSK3beta), a serine/threonine protein kinase, has emerged as a therapeutic target for common chronic diseases including type 2 diabetes mellitus, neurodegenerative disorders, inflammation and osteoporosis. This is based on its currently known functions and primary pathologic causalities. GSK3beta has well characterized roles in the regulation of gene transcription and in oncogenic signaling. We have shown that deregulated GSK3beta promotes gastrointestinal, pancreatic and liver cancers and glioblastomas. Furthermore, we have demonstrated that inhibition of GSK3beta attenuates cell survival and proliferation, induces cell senescence and apoptosis and sensitizes tumor cells to chemotherapeutic agents and ionizing radiation. This has led us to propose GSK3beta as a potential therapeutic target in cancer. The anti-tumor effects of GSK3beta inhibition are mediated by changes in the expression and phosphorylation of molecules critical to the regulation of cell cycling, proliferation and apoptosis and underlie the pathological role for GSK3beta in cancer. Investigation of the mechanisms responsible for deregulation of GSK3beta and the consequent downstream pathologic effects in cancer cells has shed light on the molecular pathways leading to tumorigenesis. This will allow exploration of novel therapeutic strategies for cancer that target aberrant GSK3beta.
Publication: Anticancer Agents Med Chem 2009 Dec ;9(10)::1114-22.
Publication Date: 2009 Dec
Study Author(s): Miyashita, Katsuyoshi;Nakada, Mitsutoshi;Shakoori, Abbas;Ishigaki, Yasuhito;Shimasaki, Takeo;Motoo, Yoshiharu;Kawakami, Kazuyuki;Minamoto, Toshinari;
Institution: Division of Translational and Clinical Oncology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Shortcut link to this study:
Publication Date: 2009 Dec
Study Author(s): Miyashita, Katsuyoshi;Nakada, Mitsutoshi;Shakoori, Abbas;Ishigaki, Yasuhito;Shimasaki, Takeo;Motoo, Yoshiharu;Kawakami, Kazuyuki;Minamoto, Toshinari;
Institution: Division of Translational and Clinical Oncology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Shortcut link to this study:
Improvement in the outcome of cancer patients who are refractory to currently available treatments relies on the development of target-directed therapies. One group of molecular targets with potential clinical relevance is a set of protein tyrosine kinases encoded mostly by proto-oncogenes and that are frequently deregulated in cancer. Glycogen synthase kinase 3beta (GSK3beta), a serine/threonine protein kinase, has emerged as a therapeutic target for common chronic diseases including type 2 diabetes mellitus, neurodegenerative disorders, inflammation and osteoporosis. This is based on its currently known functions and primary pathologic causalities. GSK3beta has well characterized roles in the regulation of gene transcription and in oncogenic signaling. We have shown that deregulated GSK3beta promotes gastrointestinal, pancreatic and liver cancers and glioblastomas. Furthermore, we have demonstrated that inhibition of GSK3beta attenuates cell survival and proliferation, induces cell senescence and apoptosis and sensitizes tumor cells to chemotherapeutic agents and ionizing radiation. This has led us to propose GSK3beta as a potential therapeutic target in cancer. The anti-tumor effects of GSK3beta inhibition are mediated by changes in the expression and phosphorylation of molecules critical to the regulation of cell cycling, proliferation and apoptosis and underlie the pathological role for GSK3beta in cancer. Investigation of the mechanisms responsible for deregulation of GSK3beta and the consequent downstream pathologic effects in cancer cells has shed light on the molecular pathways leading to tumorigenesis. This will allow exploration of novel therapeutic strategies for cancer that target aberrant GSK3beta.
PMID: 19925395
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