|
|
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result sql = All-cause mortality after diabetes-related amputation in Barbados: a prospective case-control study.
All-cause mortality after diabetes-related amputation in Barbados: a prospective case-control study.char = <;code = 60
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result sql = OBJECTIVE : To determine the mortality rate after diabetes-related lower-extremity amputation (LEA) in an African-descent Caribbean population.
RESEARCH DESIGN AND METHODS : We conducted a prospective case-control study. We recruited case subjects (with diabetes and LEA) and age-matched control subjects (with diabetes and no LEA) between 1999 and 2001. We followed these groups for 5 years to assess mortality risk and causes.
RESULTS : There were 205 amputations (123 minor and 82 major). The 1-year and 5-year survival rates were 69 and 44% among case subjects and 97 and 82% among control subjects (case-control difference, P < 0.001). The mortality rates (per 1,000 person-years) were 273.9 (95% CI 207.1-362.3) after a major amputation, 113.4 (85.2-150.9) after a minor amputation, and 36.4 (25.6-51.8) among control subjects. Sepsis and cardiac disease were the most common causes of death.
CONCLUSIONS : These mortality rates are the highest reported worldwide. Interventions to limit sepsis and complications from cardiac disease offer a huge potential for improving post-LEA survival in this vulnerable group.
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result sql = All-cause mortality after diabetes-related amputation in Barbados: a prospective case-control study.
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char = l;code = 108
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char = t;code = 116
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char = ;code = 32
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = (;code = 40
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char = t;code = 116
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char = .;code = 46
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char = .;code = 46
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char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = .;code = 46
char = ;code = 32
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char = e;code = 101
char = p;code = 112
char = s;code = 115
char = i;code = 105
char = s;code = 115
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char = e;code = 101
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char = u;code = 117
char = s;code = 115
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char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
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char = ;code = 32
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char = b;code = 98
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char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = o;code = 111
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char = a;code = 97
char = l;code = 108
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char = ;code = 32
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char = ;code = 32
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char = g;code = 103
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char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
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char = r;code = 114
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char = w;code = 119
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char = e;code = 101
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char = s;code = 115
char = ;code = 32
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char = m;code = 109
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char = t;code = 116
char = ;code = 32
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char = e;code = 101
char = p;code = 112
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char = i;code = 105
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = c;code = 99
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = -;code = 45
char = L;code = 76
char = E;code = 69
char = A;code = 65
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = v;code = 118
char = u;code = 117
char = l;code = 108
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = .;code = 46
result sql = OBJECTIVE : To determine the mortality rate after diabetes-related lower-extremity amputation (LEA) in an African-descent Caribbean population.
RESEARCH DESIGN AND METHODS : We conducted a prospective case-control study. We recruited case subjects (with diabetes and LEA) and age-matched control subjects (with diabetes and no LEA) between 1999 and 2001. We followed these groups for 5 years to assess mortality risk and causes.
RESULTS : There were 205 amputations (123 minor and 82 major). The 1-year and 5-year survival rates were 69 and 44% among case subjects and 97 and 82% among control subjects (case-control difference, P < 0.001). The mortality rates (per 1,000 person-years) were 273.9 (95% CI 207.1-362.3) after a major amputation, 113.4 (85.2-150.9) after a minor amputation, and 36.4 (25.6-51.8) among control subjects. Sepsis and cardiac disease were the most common causes of death.
CONCLUSIONS : These mortality rates are the highest reported worldwide. Interventions to limit sepsis and complications from cardiac disease offer a huge potential for improving post-LEA survival in this vulnerable group.
Publication: Diabetes Care 2009 Feb ;32(2)::306-7. :doi: 10.2337/dc08-1504.
Publication Date: 2009 Feb
Study Author(s): Hambleton, Ian R;Jonnalagadda, Ramesh;Davis, Christopher R;Fraser, Henry S;Chaturvedi, Nish;Hennis, Anselm J;
Institution: Chronic Disease Research Centre, Tropical Medicine Research Institute, University of the West Indies, Barbados. [email protected]
Shortcut link to this study:
Publication Date: 2009 Feb
Study Author(s): Hambleton, Ian R;Jonnalagadda, Ramesh;Davis, Christopher R;Fraser, Henry S;Chaturvedi, Nish;Hennis, Anselm J;
Institution: Chronic Disease Research Centre, Tropical Medicine Research Institute, University of the West Indies, Barbados. [email protected]
Shortcut link to this study:
OBJECTIVE : To determine the mortality rate after diabetes-related lower-extremity amputation (LEA) in an African-descent Caribbean population.
RESEARCH DESIGN AND METHODS : We conducted a prospective case-control study. We recruited case subjects (with diabetes and LEA) and age-matched control subjects (with diabetes and no LEA) between 1999 and 2001. We followed these groups for 5 years to assess mortality risk and causes.
RESULTS : There were 205 amputations (123 minor and 82 major). The 1-year and 5-year survival rates were 69 and 44% among case subjects and 97 and 82% among control subjects (case-control difference, P < 0.001). The mortality rates (per 1,000 person-years) were 273.9 (95% CI 207.1-362.3) after a major amputation, 113.4 (85.2-150.9) after a minor amputation, and 36.4 (25.6-51.8) among control subjects. Sepsis and cardiac disease were the most common causes of death.
CONCLUSIONS : These mortality rates are the highest reported worldwide. Interventions to limit sepsis and complications from cardiac disease offer a huge potential for improving post-LEA survival in this vulnerable group.
RESEARCH DESIGN AND METHODS : We conducted a prospective case-control study. We recruited case subjects (with diabetes and LEA) and age-matched control subjects (with diabetes and no LEA) between 1999 and 2001. We followed these groups for 5 years to assess mortality risk and causes.
RESULTS : There were 205 amputations (123 minor and 82 major). The 1-year and 5-year survival rates were 69 and 44% among case subjects and 97 and 82% among control subjects (case-control difference, P < 0.001). The mortality rates (per 1,000 person-years) were 273.9 (95% CI 207.1-362.3) after a major amputation, 113.4 (85.2-150.9) after a minor amputation, and 36.4 (25.6-51.8) among control subjects. Sepsis and cardiac disease were the most common causes of death.
CONCLUSIONS : These mortality rates are the highest reported worldwide. Interventions to limit sepsis and complications from cardiac disease offer a huge potential for improving post-LEA survival in this vulnerable group.
PMID: 18984775
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