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char = o;code = 111
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char = ;code = 32
char = (;code = 40
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char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = c;code = 99
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char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Wilms' tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells.
Wilms' tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells.
char = T;code = 84
char = h;code = 104
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char = i;code = 105
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char = c;code = 99
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char = c;code = 99
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char = l;code = 108
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char = c;code = 99
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char = y;code = 121
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char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
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char = i;code = 105
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char = p;code = 112
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char = e;code = 101
char = a;code = 97
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char = c;code = 99
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = ;code = 32
char = C;code = 67
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char = r;code = 114
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char = u;code = 117
char = m;code = 109
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char = e;code = 101
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char = l;code = 108
char = e;code = 101
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char = o;code = 111
char = f;code = 102
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char = W;code = 87
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char = 1;code = 49
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char = i;code = 105
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char = ;code = 32
char = c;code = 99
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char = ;code = 32
char = T;code = 84
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char = c;code = 99
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char = m;code = 109
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char = P;code = 80
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result sql = The transcription factor WT1 plays an important role in cellular proliferation and survival of various cancer cells, and is frequently expressed in pancreatic cancer. Curcumin has been shown to be a potentially effective agent in pancreatic cancer. In this context, the purpose of this study was to determine the role of WT1 in a curcumin-treated pancreatic cancer cell line. To study the effect of curcumin on the expression of WT1, we incubated the pancreatic cancer cell line PANC-1 with different amounts of curcumin. The expression of WT1 on mRNA and protein level was measured with real-time RT-PCR and Western blot analysis. The incubation of the pancreatic cancer cell line PANC-1 with curcumin resulted in an inhibition of cellular proliferation as measured with MTT assay. The expression of WT1 on mRNA and protein level was significantly down-regulated in a concentration-dependent manner after treatment with curcumin. The WT1 mRNA levels were decreased by 20%, 25%, 40%, 78% and 88% in response to 10, 20, 30, 40 and 50 microM curcumin. The use of small inhibitory RNA (siRNA) targeting WT1 down-regulated the expression of WT1 about 90%. Combined treatment with curcumin and siRNA targeting WT1 resulted in a significant inhibition of cell proliferation compared to curcumin-treated cells alone. In conclusion, WT1 is involved in cellular proliferation of PANC-1 cells. Targeting WT1 gene expression with siRNA may enhance the efficacy of curcumin to inhibit cell proliferation.

Publication: Eur. J. Cancer 2009 Mar ;45(5)::874-80. :doi: 10.1016/j.ejca.2008.12.030.
Publication Date: 2009 Mar
Study Author(s): Glienke, Wolfgang;Maute, Luise;Wicht, Johannes;Bergmann, Lothar;
Institution: Department of Medicine II (Hämatologie/Onkologie), University Hospital, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.
Shortcut link to this study:
The transcription factor WT1 plays an important role in cellular proliferation and survival of various cancer cells, and is frequently expressed in pancreatic cancer. Curcumin has been shown to be a potentially effective agent in pancreatic cancer. In this context, the purpose of this study was to determine the role of WT1 in a curcumin-treated pancreatic cancer cell line. To study the effect of curcumin on the expression of WT1, we incubated the pancreatic cancer cell line PANC-1 with different amounts of curcumin. The expression of WT1 on mRNA and protein level was measured with real-time RT-PCR and Western blot analysis. The incubation of the pancreatic cancer cell line PANC-1 with curcumin resulted in an inhibition of cellular proliferation as measured with MTT assay. The expression of WT1 on mRNA and protein level was significantly down-regulated in a concentration-dependent manner after treatment with curcumin. The WT1 mRNA levels were decreased by 20%, 25%, 40%, 78% and 88% in response to 10, 20, 30, 40 and 50 microM curcumin. The use of small inhibitory RNA (siRNA) targeting WT1 down-regulated the expression of WT1 about 90%. Combined treatment with curcumin and siRNA targeting WT1 resulted in a significant inhibition of cell proliferation compared to curcumin-treated cells alone. In conclusion, WT1 is involved in cellular proliferation of PANC-1 cells. Targeting WT1 gene expression with siRNA may enhance the efficacy of curcumin to inhibit cell proliferation.
PMID: 19196508

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