|
|
char = V;code = 86
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char = D;code = 68
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result sql = Vitamin D and skin cancer: a meta-analysis.
Vitamin D and skin cancer: a meta-analysis.char = A;code = 65
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char = a;code = 97
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char = i;code = 105
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char = c;code = 99
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char = M;code = 77
char = S;code = 83
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char = V;code = 86
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char = m;code = 109
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char = p;code = 112
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char = s;code = 115
char = m;code = 109
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char = ;code = 32
char = F;code = 70
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char = I;code = 73
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char = a;code = 97
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char = B;code = 66
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char = V;code = 86
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char = a;code = 97
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char = t;code = 116
char = o;code = 111
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char = a;code = 97
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char = f;code = 102
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char = 6;code = 54
char = 8;code = 56
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char = c;code = 99
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char = s;code = 115
char = .;code = 46
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char = W;code = 87
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char = f;code = 102
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char = d;code = 100
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char = a;code = 97
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char = a;code = 97
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char = M;code = 77
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result sql = A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases. We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively. The SRR for ff versus wild-type became significant with the inclusion of NMSC. THE SRR FOR THE STUDIES ON CMM WERE: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively. There is also a slight indication of a role of dietary Vitamin D in CMM development. In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet.
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result sql = Vitamin D and skin cancer: a meta-analysis.
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char = s;code = 115
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char = v;code = 118
char = e;code = 101
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char = h;code = 104
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char = r;code = 114
char = e;code = 101
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char = i;code = 105
char = s;code = 115
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char = o;code = 111
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = s;code = 115
char = l;code = 108
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = r;code = 114
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char = l;code = 108
char = e;code = 101
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char = o;code = 111
char = f;code = 102
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
char = n;code = 110
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char = .;code = 46
char = ;code = 32
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char = n;code = 110
char = ;code = 32
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char = n;code = 110
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char = u;code = 117
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char = i;code = 105
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char = a;code = 97
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char = n;code = 110
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char = y;code = 121
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char = g;code = 103
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char = a;code = 97
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char = l;code = 108
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
char = f;code = 102
char = u;code = 117
char = r;code = 114
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
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char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = u;code = 117
char = l;code = 108
char = d;code = 100
char = ;code = 32
char = b;code = 98
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char = ;code = 32
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = f;code = 102
char = u;code = 117
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
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char = i;code = 105
char = f;code = 102
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
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char = <;code = 60
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result sql = A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases. We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively. The SRR for ff versus wild-type became significant with the inclusion of NMSC. THE SRR FOR THE STUDIES ON CMM WERE: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively. There is also a slight indication of a role of dietary Vitamin D in CMM development. In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet.
Publication: Eur. J. Cancer 2009 Mar ;45(4)::634-41. :doi: 10.1016/j.ejca.2008.10.003.
Publication Date: 2009 Mar
Study Author(s): Gandini, Sara;Raimondi, Sara;Gnagnarella, Patrizia;Doré, Jean-Francois;Maisonneuve, Patrick;Testori, Alessandro;
Institution: Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. [email protected]
Shortcut link to this study:
Publication Date: 2009 Mar
Study Author(s): Gandini, Sara;Raimondi, Sara;Gnagnarella, Patrizia;Doré, Jean-Francois;Maisonneuve, Patrick;Testori, Alessandro;
Institution: Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. [email protected]
Shortcut link to this study:
A comprehensive bibliographic search of the literature was conducted to identify studies on Cutaneous Malignant Melanoma (CMM) and non-melanoma skin cancer (NMSC), Vitamin D receptor (VDR) polymorphisms, Vitamin D intake and 25(OH)D serum levels. Fully adjusted risk estimates were found and extracted for the two polymorphisms FokI and BsmI and Vitamin D intake. Ten studies were included in the meta-analysis, with a total of 6805 skin cancer cases. We found an association with CMM for both polymorphisms. The summary relative risks (SRR) for the studies on CMM were: 1.21 (1.03-1.42) and 1.21 (0.95-1.54) for the Ff and ff versus wild-type of FokI, respectively. The SRR for ff versus wild-type became significant with the inclusion of NMSC. THE SRR FOR THE STUDIES ON CMM WERE: 0.78 (0.65-0.92) and 0.75 (0.59-0.95) for the Bb and BB versus wild-type of BsmI, respectively. There is also a slight indication of a role of dietary Vitamin D in CMM development. In conclusion, this meta-analysis suggests a possible significant role of VDR FokI and BsmI polymorphism in CMM and NMSC risk. The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet.
PMID: 19008093
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