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char = m;code = 109
char = i;code = 105
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char = ;code = 32
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char = r;code = 114
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = .;code = 46
result sql = Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
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char = e;code = 101
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char = s;code = 115
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char = l;code = 108
char = y;code = 121
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = 8;code = 56
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char = ;code = 32
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char = C;code = 67
char = ,;code = 44
char = ;code = 32
char = C;code = 67
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
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char = 2;code = 50
char = 5;code = 53
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char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
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char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
char = [;code = 91
char = 2;code = 50
char = 5;code = 53
char = (;code = 40
char = O;code = 79
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char = D;code = 68
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char = a;code = 97
char = m;code = 109
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char = n;code = 110
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char = ;code = 32
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char = 1;code = 49
char = ,;code = 44
char = 2;code = 50
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char = O;code = 79
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char = );code = 41
char = (;code = 40
char = 2;code = 50
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char = ];code = 93
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char = l;code = 108
char = ;code = 32
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char = 6;code = 54
char = 4;code = 52
char = ;code = 32
char = S;code = 83
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char = P;code = 80
char = S;code = 83
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char = i;code = 105
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char = m;code = 109
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char = o;code = 111
char = f;code = 102
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char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
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char = g;code = 103
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = [;code = 91
char = V;code = 86
char = D;code = 68
char = R;code = 82
char = ,;code = 44
char = ;code = 32
char = R;code = 82
char = X;code = 88
char = R;code = 82
char = A;code = 65
char = ,;code = 44
char = ;code = 32
char = R;code = 82
char = X;code = 88
char = R;code = 82
char = B;code = 66
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char = ;code = 32
char = P;code = 80
char = P;code = 80
char = A;code = 65
char = R;code = 82
char = ,;code = 44
char = ;code = 32
char = N;code = 78
char = C;code = 67
char = O;code = 79
char = A;code = 65
char = 1;code = 49
char = ,;code = 44
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char = C;code = 67
char = O;code = 79
char = A;code = 65
char = 2;code = 50
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char = A;code = 65
char = 3;code = 51
char = ;code = 32
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char = S;code = 83
char = M;code = 77
char = A;code = 65
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char = 3;code = 51
char = ];code = 93
char = ;code = 32
char = w;code = 119
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char = ;code = 32
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char = r;code = 114
char = o;code = 111
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char = a;code = 97
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char = e;code = 101
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char = c;code = 99
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char = c;code = 99
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char = r;code = 114
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char = r;code = 114
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char = s;code = 115
char = k;code = 107
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = 7;code = 55
char = 4;code = 52
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char = t;code = 116
char = o;code = 111
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char = P;code = 80
char = S;code = 83
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char = n;code = 110
char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = n;code = 110
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = ';code = 39
char = ;code = 32
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char = n;code = 110
char = t;code = 116
char = r;code = 114
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char = n;code = 110
char = s;code = 115
char = l;code = 108
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = i;code = 105
char = o;code = 111
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char = (;code = 40
char = U;code = 85
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char = R;code = 82
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char = ;code = 32
char = o;code = 111
char = f;code = 102
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char = V;code = 86
char = D;code = 68
char = R;code = 82
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char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
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char = ;code = 32
char = t;code = 116
char = h;code = 104
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char = t;code = 116
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char = s;code = 115
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char = i;code = 105
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char = r;code = 114
char = ;code = 32
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char = 1;code = 49
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char = 1;code = 49
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char = o;code = 111
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char = r;code = 114
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char = P;code = 80
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char = ;code = 32
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char = e;code = 101
char = n;code = 110
char = o;code = 111
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char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
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char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = l;code = 108
char = l;code = 108
char = ;code = 32
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char = m;code = 109
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = 2;code = 50
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = 3;code = 51
char = .;code = 46
char = ;code = 32
char = R;code = 82
char = e;code = 101
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = ;code = 32
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char = p;code = 112
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char = e;code = 101
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
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char = a;code = 97
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = n;code = 110
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
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char = u;code = 117
char = g;code = 103
char = g;code = 103
char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = t;code = 116
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char = t;code = 116
char = ;code = 32
char = t;code = 116
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char = g;code = 103
char = ;code = 32
char = S;code = 83
char = N;code = 78
char = P;code = 80
char = S;code = 83
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = ';code = 39
char = ;code = 32
char = U;code = 85
char = T;code = 84
char = R;code = 82
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = D;code = 68
char = R;code = 82
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char = a;code = 97
char = y;code = 121
char = ;code = 32
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char = e;code = 101
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = We systematically investigated the association of 48 SNPS in four vitamin D metabolizing genes [CYP27A1, GC, CYP27B1 and CYP24A1] with serum 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels and the association of these SNPS and an additional 164 SNPS in eight downstream mediators of vitamin D signaling [VDR, RXRA, RXRB, PPAR, NCOA1, NCOA2, NCOA3 and SMAD3] with prostate cancer risk in the 749 incident prostate cancer cases and 781 controls of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. 25(OH)D (all cases and controls) and 1,25(OH)(2)D (a subset of 150 controls) levels were measured by radioimmunoassay and SNP data were genotyped as part of a genome-wide scan. Among investigated SNPS, only four tag SNPS in GC, the major serum 25(OH)D carrier, were associated with 25(OH)D levels; no SNPS were associated with 1,25(OH)(2)D levels. None of the 212 SNPS examined were associated with cancer risk overall. Among men in the lowest tertile of serum 25(OH)D (<48.9 nmol/l), however, prostate cancer risk was related to tag SNPS in or near the 3' untranslated region (UTR) of VDR, with the strongest association for rs11574143 [odds ratio (95% confidence interval) for risk allele carriers versus wild-type: 2.49 (1.51-4.11), P = 0.0007]; the genotype associations were null among men in tertile 2 and tertile 3. Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status.

Publication: Carcinogenesis 2009 May ;30(5)::769-76. :doi: 10.1093/carcin/bgp055.
Publication Date: 2009 May
Study Author(s): Ahn, Jiyoung;Albanes, Demetrius;Berndt, Sonja I;Peters, Ulrike;Chatterjee, Nilanjan;Freedman, Neal D;Abnet, Christian C;Huang, Wen-Yi;Kibel, Adam S;Crawford, E David;Weinstein, Stephanie J;Chanock, Stephen J;Schatzkin, Arthur;Hayes, Richard B;Prostate, Lung, Colorectal and Ovarian Trial Project Team;
Institution: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA. [email protected]
Shortcut link to this study:
We systematically investigated the association of 48 SNPS in four vitamin D metabolizing genes [CYP27A1, GC, CYP27B1 and CYP24A1] with serum 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels and the association of these SNPS and an additional 164 SNPS in eight downstream mediators of vitamin D signaling [VDR, RXRA, RXRB, PPAR, NCOA1, NCOA2, NCOA3 and SMAD3] with prostate cancer risk in the 749 incident prostate cancer cases and 781 controls of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. 25(OH)D (all cases and controls) and 1,25(OH)(2)D (a subset of 150 controls) levels were measured by radioimmunoassay and SNP data were genotyped as part of a genome-wide scan. Among investigated SNPS, only four tag SNPS in GC, the major serum 25(OH)D carrier, were associated with 25(OH)D levels; no SNPS were associated with 1,25(OH)(2)D levels. None of the 212 SNPS examined were associated with cancer risk overall. Among men in the lowest tertile of serum 25(OH)D (<48.9 nmol/l), however, prostate cancer risk was related to tag SNPS in or near the 3' untranslated region (UTR) of VDR, with the strongest association for rs11574143 [odds ratio (95% confidence interval) for risk allele carriers versus wild-type: 2.49 (1.51-4.11), P = 0.0007]; the genotype associations were null among men in tertile 2 and tertile 3. Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status.
PMID: 19255064

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