|
|
char = R;code = 82
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result sql = Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy.
Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy.char = <;code = 60
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char = ;code = 32
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char = a;code = 97
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char = ;code = 32
char = t;code = 116
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char = a;code = 97
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char = i;code = 105
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char = c;code = 99
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char = <;code = 60
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char = T;code = 84
char = S;code = 83
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char = H;code = 72
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char = <;code = 60
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char = A;code = 65
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char = a;code = 97
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char = u;code = 117
char = a;code = 97
char = l;code = 108
char = ;code = 32
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char = r;code = 114
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char = s;code = 115
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result sql = PURPOSE : Glioblastoma multiforme is the prototype of an angiogenic tumour. Under experimental conditions, anti-angiogenic therapy strategies lead to an increased invasion. Here we report on the pattern of tumour recurrence in glioblastoma patients treated with an anti-angiogenic chemotherapy.
PATIENTS AND METHODS : A total of 32 patients with glioblastoma multiforme and a residual tumour mass after operation were treated with a continuous low-dose chemotherapy with temozolomide and a COX-II inhibitor, a presumably anti-angiogenic therapy.
RESULTS : While anti-tumour activity of this therapy regimen was excellent with a mean overall time to progression of 10.4 (+/-0.9) months and a mean overall survival of 17.8 (+/-1.5) months, an unusually high rate of distant recurrences was observed (62.5%).
CONCLUSION : Patients treated with an anti-angiogenic chemotherapy experience distant recurrences at a higher rate than reported for conventional therapies. This may reflect an anti-angiogenic therapy-induced activation of glioma invasion confirming similar recently published experimental results.
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result sql = Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy.
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char = s;code = 115
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char = n;code = 110
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char = s;code = 115
char = u;code = 117
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char = h;code = 104
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char = ;code = 32
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char = s;code = 115
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char = r;code = 114
char = v;code = 118
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char = d;code = 100
char = ;code = 32
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char = 2;code = 50
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char = 5;code = 53
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char = .;code = 46
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char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
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char = ;code = 32
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char = t;code = 116
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char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = i;code = 105
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char = h;code = 104
char = e;code = 101
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char = ;code = 32
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char = a;code = 97
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char = r;code = 114
char = e;code = 101
char = f;code = 102
char = l;code = 108
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char = ;code = 32
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char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = g;code = 103
char = l;code = 108
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char = o;code = 111
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = a;code = 97
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = i;code = 105
char = r;code = 114
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = u;code = 117
char = b;code = 98
char = l;code = 108
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = e;code = 101
char = d;code = 100
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char = x;code = 120
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = u;code = 117
char = l;code = 108
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result sql = PURPOSE : Glioblastoma multiforme is the prototype of an angiogenic tumour. Under experimental conditions, anti-angiogenic therapy strategies lead to an increased invasion. Here we report on the pattern of tumour recurrence in glioblastoma patients treated with an anti-angiogenic chemotherapy.
PATIENTS AND METHODS : A total of 32 patients with glioblastoma multiforme and a residual tumour mass after operation were treated with a continuous low-dose chemotherapy with temozolomide and a COX-II inhibitor, a presumably anti-angiogenic therapy.
RESULTS : While anti-tumour activity of this therapy regimen was excellent with a mean overall time to progression of 10.4 (+/-0.9) months and a mean overall survival of 17.8 (+/-1.5) months, an unusually high rate of distant recurrences was observed (62.5%).
CONCLUSION : Patients treated with an anti-angiogenic chemotherapy experience distant recurrences at a higher rate than reported for conventional therapies. This may reflect an anti-angiogenic therapy-induced activation of glioma invasion confirming similar recently published experimental results.
Publication: J. Cancer Res. Clin. Oncol. 2009 Sep ;135(9)::1239-44. :doi: 10.1007/s00432-009-0565-9.
Publication Date: 2009 Sep
Study Author(s): Tuettenberg, Jochen;Grobholz, Rainer;Seiz, Marcel;Brockmann, Marc A;Lohr, Frank;Wenz, Frederik;Vajkoczy, Peter;
Institution: Department of Neurosurgery, Universitätsmedizin Mannheim, University of Heidelberg, 68167 Mannheim, Germany. [email protected]
Shortcut link to this study:
Publication Date: 2009 Sep
Study Author(s): Tuettenberg, Jochen;Grobholz, Rainer;Seiz, Marcel;Brockmann, Marc A;Lohr, Frank;Wenz, Frederik;Vajkoczy, Peter;
Institution: Department of Neurosurgery, Universitätsmedizin Mannheim, University of Heidelberg, 68167 Mannheim, Germany. [email protected]
Shortcut link to this study:
PURPOSE : Glioblastoma multiforme is the prototype of an angiogenic tumour. Under experimental conditions, anti-angiogenic therapy strategies lead to an increased invasion. Here we report on the pattern of tumour recurrence in glioblastoma patients treated with an anti-angiogenic chemotherapy.
PATIENTS AND METHODS : A total of 32 patients with glioblastoma multiforme and a residual tumour mass after operation were treated with a continuous low-dose chemotherapy with temozolomide and a COX-II inhibitor, a presumably anti-angiogenic therapy.
RESULTS : While anti-tumour activity of this therapy regimen was excellent with a mean overall time to progression of 10.4 (+/-0.9) months and a mean overall survival of 17.8 (+/-1.5) months, an unusually high rate of distant recurrences was observed (62.5%).
CONCLUSION : Patients treated with an anti-angiogenic chemotherapy experience distant recurrences at a higher rate than reported for conventional therapies. This may reflect an anti-angiogenic therapy-induced activation of glioma invasion confirming similar recently published experimental results.
PATIENTS AND METHODS : A total of 32 patients with glioblastoma multiforme and a residual tumour mass after operation were treated with a continuous low-dose chemotherapy with temozolomide and a COX-II inhibitor, a presumably anti-angiogenic therapy.
RESULTS : While anti-tumour activity of this therapy regimen was excellent with a mean overall time to progression of 10.4 (+/-0.9) months and a mean overall survival of 17.8 (+/-1.5) months, an unusually high rate of distant recurrences was observed (62.5%).
CONCLUSION : Patients treated with an anti-angiogenic chemotherapy experience distant recurrences at a higher rate than reported for conventional therapies. This may reflect an anti-angiogenic therapy-induced activation of glioma invasion confirming similar recently published experimental results.
PMID: 19277712
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