Characterization of STAT3 activation and expression in canine and human osteosarcoma.

Publication: BMC cancer
Publication Date: 2009
Study Author(s): Fossey, Stacey L;Liao, Albert T;McCleese, Jennifer K;Bear, Misty D;Lin, Jiayuh;Li, Pui-Kai;Kisseberth, William C;London, Cheryl A;
Institution: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Shortcut link to this study:
Dysregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a key participant in Tumor cell survival, proliferation, and metastasis and is often correlated with a more malignant tumor phenotype. STAT3 phosphorylation has been demonstrated in a subset of human Osteosarcoma (OSA) tissues and cell lines. OSA in the canine population is known to exhibit a similar clinical behavior and molecular biology when compared to its human counterpart, and is often used as a model for preclinical testing of novel therapeutics. The purpose of this study was to investigate the potential role of STAT3 in canine and human OSA, and to evaluate the biologic activity of a novel small molecule STAT3 Inhibitor.
PMID: 19284568

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