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result sql = Conjugation with alpha-linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin.
Conjugation with alpha-linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin.
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result sql = The synthetic DOX-LNA conjugate was characterized by proton nuclear magnetic resonance and mass spectrometry. In addition, the purity of the conjugate was analyzed by reverse-phase high-performance liquid chromatography. The cellular uptake, intracellular distribution, and cytotoxicity of DOX-LNA were assessed by flow cytometry, fluorescence microscopy, liquid chromatography/electrospray ionization tandem mass spectrometry, and the tetrazolium dye assay using the in vitro cell models. The DOX-LNA conjugate showed substantially higher tumor-specific cytotoxicity compared with DOX.

Publication: Bioorg. Med. Chem. Lett. 2009 May 1 ;19(9)::2579-84. :doi: 10.1016/j.bmcl.2009.03.016.
Publication Date: 2009 May 1
Study Author(s): Huan, Meng-Lei;Zhou, Si-Yuan;Teng, Zeng-Hui;Zhang, Bang-le;Liu, Xin-You;Wang, Jie-Pin;Mei, Qi-Bing;
Institution: Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, 17, Changle West Road, Xi'an, Shaan'xi 710032, China.
Shortcut link to this study:
The synthetic DOX-LNA conjugate was characterized by proton nuclear magnetic resonance and mass spectrometry. In addition, the purity of the conjugate was analyzed by reverse-phase high-performance liquid chromatography. The cellular uptake, intracellular distribution, and cytotoxicity of DOX-LNA were assessed by flow cytometry, fluorescence microscopy, liquid chromatography/electrospray ionization tandem mass spectrometry, and the tetrazolium dye assay using the in vitro cell models. The DOX-LNA conjugate showed substantially higher tumor-specific cytotoxicity compared with DOX.
PMID: 19329312

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