|
|
char = A;code = 65
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char = n;code = 110
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char = a;code = 97
char = s;code = 115
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char = c;code = 99
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char = n;code = 110
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = e;code = 101
char = .;code = 46
result sql = A synthetic coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice.
A synthetic coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice.char = S;code = 83
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char = o;code = 111
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char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = a;code = 97
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char = k;code = 107
char = a;code = 97
char = l;code = 108
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char = a;code = 97
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char = x;code = 120
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char = G;code = 71
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char = ;code = 32
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char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = p;code = 112
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char = r;code = 114
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char = d;code = 100
char = ;code = 32
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char = s;code = 115
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char = i;code = 105
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result sql = Scopoletin, an alkaloid separated from ethanolic extract of the medicinal plant, Gelsemium sempervirens (FAM: Loganiaceae) has been reported to have anti-cancer potentials. The synthetic coumarin (4-Methyl-7 hydroxy coumarin) derived from resorcinol and ethyl aceto-acetate in presence of concentrated sulphuric acid is structurally close to scopoletin, being a coumarin derivative. Whether this synthetic compound also has anti-cancer potentials has been evaluated in vivo on DMBA (7,12-Dimethylbenz[a]anthracene) induced skin cancer in mice by analyzing results of several cytogenetic endpoints, Comet assay, and fluorescence activated cell sorting (FACS). Further, expressions of signal proteins like Aryl hydrocarbon receptor , p53, PCNA, Akt, Bcl-2, Bcl-xL, Bad, Bax, NF-kappaB Apaf, IL-6, Cytochrome-c, Caspase-3 and Caspase-9 were studied by immunoblot analysis along with histology of skin and immuno-histochemical localization of Aryl hydrocarbon receptor and PCNA in DMBA treated mice vis-a-vis carcinogen treated synthetic coumarin fed mice. Feeding of this synthetic coumarin induced positive modulations in expression of all biomarkers in DMBA administered mice, giving clues on its possible signaling pathway(s) - primarily through down-regulation of Aryl hydrocarbon receptor and PCNA and up-regulation of apoptotic proteins like Bax, Bad, Cytochrome c, Apaf, Caspase-3 and Caspase-9, resulting in an appreciable reduction in growth of papilloma in mice. Therefore, this synthetic coumarin shows promise for use in cancer therapy, particularly in skin cancer.
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char = c;code = 99
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char = n;code = 110
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = e;code = 101
char = .;code = 46
result sql = A synthetic coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice.
char = c;code = 99
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char = p;code = 112
char = o;code = 111
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char = k;code = 107
char = a;code = 97
char = l;code = 108
char = o;code = 111
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char = d;code = 100
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char = a;code = 97
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char = m;code = 109
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char = x;code = 120
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char = c;code = 99
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char = m;code = 109
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char = G;code = 71
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char = F;code = 70
char = A;code = 65
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char = <;code = 60
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char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
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char = r;code = 114
char = e;code = 101
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char = r;code = 114
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = i;code = 105
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = ;code = 32
char = T;code = 84
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char = s;code = 115
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = c;code = 99
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char = u;code = 117
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char = a;code = 97
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = 4;code = 52
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char = M;code = 77
char = e;code = 101
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char = l;code = 108
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char = 7;code = 55
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char = x;code = 120
char = y;code = 121
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char = c;code = 99
char = o;code = 111
char = u;code = 117
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char = );code = 41
char = ;code = 32
char = d;code = 100
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char = ;code = 32
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char = a;code = 97
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char = e;code = 101
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char = i;code = 105
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char = e;code = 101
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char = c;code = 99
char = e;code = 101
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char = c;code = 99
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char = e;code = 101
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char = s;code = 115
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char = l;code = 108
char = p;code = 112
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char = u;code = 117
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = c;code = 99
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char = d;code = 100
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
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char = r;code = 114
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char = c;code = 99
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = l;code = 108
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char = c;code = 99
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char = o;code = 111
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char = s;code = 115
char = c;code = 99
char = o;code = 111
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char = W;code = 87
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char = e;code = 101
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char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
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result sql = Scopoletin, an alkaloid separated from ethanolic extract of the medicinal plant, Gelsemium sempervirens (FAM: Loganiaceae) has been reported to have anti-cancer potentials. The synthetic coumarin (4-Methyl-7 hydroxy coumarin) derived from resorcinol and ethyl aceto-acetate in presence of concentrated sulphuric acid is structurally close to scopoletin, being a coumarin derivative. Whether this synthetic compound also has anti-cancer potentials has been evaluated in vivo on DMBA (7,12-Dimethylbenz[a]anthracene) induced skin cancer in mice by analyzing results of several cytogenetic endpoints, Comet assay, and fluorescence activated cell sorting (FACS). Further, expressions of signal proteins like Aryl hydrocarbon receptor , p53, PCNA, Akt, Bcl-2, Bcl-xL, Bad, Bax, NF-kappaB Apaf, IL-6, Cytochrome-c, Caspase-3 and Caspase-9 were studied by immunoblot analysis along with histology of skin and immuno-histochemical localization of Aryl hydrocarbon receptor and PCNA in DMBA treated mice vis-a-vis carcinogen treated synthetic coumarin fed mice. Feeding of this synthetic coumarin induced positive modulations in expression of all biomarkers in DMBA administered mice, giving clues on its possible signaling pathway(s) - primarily through down-regulation of Aryl hydrocarbon receptor and PCNA and up-regulation of apoptotic proteins like Bax, Bad, Cytochrome c, Apaf, Caspase-3 and Caspase-9, resulting in an appreciable reduction in growth of papilloma in mice. Therefore, this synthetic coumarin shows promise for use in cancer therapy, particularly in skin cancer.
Publication: Eur. J. Pharmacol. 2009 Jul 1 ;614(1-3)::128-36. :doi: 10.1016/j.ejphar.2009.04.015.
Publication Date: 2009 Jul 1
Study Author(s): Bhattacharyya, Soumya S;Paul, Saili;Mandal, Sushil K;Banerjee, Antara;Boujedaini, Naoual;Khuda-Bukhsh, Anisur R;
Institution: Department of Zoology, University of Kalyani, Kalyani-741235, India.
Shortcut link to this study:
Publication Date: 2009 Jul 1
Study Author(s): Bhattacharyya, Soumya S;Paul, Saili;Mandal, Sushil K;Banerjee, Antara;Boujedaini, Naoual;Khuda-Bukhsh, Anisur R;
Institution: Department of Zoology, University of Kalyani, Kalyani-741235, India.
Shortcut link to this study:
Scopoletin, an alkaloid separated from ethanolic extract of the medicinal plant, Gelsemium sempervirens (FAM: Loganiaceae) has been reported to have anti-cancer potentials. The synthetic coumarin (4-Methyl-7 hydroxy coumarin) derived from resorcinol and ethyl aceto-acetate in presence of concentrated sulphuric acid is structurally close to scopoletin, being a coumarin derivative. Whether this synthetic compound also has anti-cancer potentials has been evaluated in vivo on DMBA (7,12-Dimethylbenz[a]anthracene) induced skin cancer in mice by analyzing results of several cytogenetic endpoints, Comet assay, and fluorescence activated cell sorting (FACS). Further, expressions of signal proteins like Aryl hydrocarbon receptor , p53, PCNA, Akt, Bcl-2, Bcl-xL, Bad, Bax, NF-kappaB Apaf, IL-6, Cytochrome-c, Caspase-3 and Caspase-9 were studied by immunoblot analysis along with histology of skin and immuno-histochemical localization of Aryl hydrocarbon receptor and PCNA in DMBA treated mice vis-a-vis carcinogen treated synthetic coumarin fed mice. Feeding of this synthetic coumarin induced positive modulations in expression of all biomarkers in DMBA administered mice, giving clues on its possible signaling pathway(s) - primarily through down-regulation of Aryl hydrocarbon receptor and PCNA and up-regulation of apoptotic proteins like Bax, Bad, Cytochrome c, Apaf, Caspase-3 and Caspase-9, resulting in an appreciable reduction in growth of papilloma in mice. Therefore, this synthetic coumarin shows promise for use in cancer therapy, particularly in skin cancer.
PMID: 19393233
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