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result sql = [The inhibitory effect of curcumin on the proliferation of HT-29 colonic cancer cell induced by deoxycholic acid].
[The inhibitory effect of curcumin on the proliferation of HT-29 colonic cancer cell induced by deoxycholic acid].
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result sql = OBJECTIVE : To assess the effect of curcumin on deoxycholic acid (DCA) induced cell proliferation in human HT-29 colon cancer cell line and to discuss its underlying anti-cancer mechanisms.

METHODS : The effect of curcumin on cell proliferation was tested in vitro with MTT assay. RT-PCR was applied to measure cyclooxygenase-2 (COX-2) mRNA transcription. Cellular immunochemical stain was applied to label COX-2 protein expression. Radio immunoassay was applied to assess prostaglandin E(2) (PGE(2)) level.

RESULTS : DCA increased cell proliferation, COX-2 mRNA expression and PGE(2) concentration of HT-29 cell line. Curcumin inhibited DCA-induced cell proliferation of HT-29 cell in a dose and time depended manner. Curcumin may inhibit DCA-induced COX-2 mRNA transcription at 6 hour with more than 5 micromol/L and at 12 hour with more than 0.5 micromol/L. However, Curcumin may decrease DCA-induced COX-2 expression and PGE(2) synthesis at 24 - 48 hour with more than 1 micromol/L and at 6-12 hour with more than 5 micromol/L.

CONCLUSIONS : Curcumin may inhibit HT-29 cell proliferation, COX-2 mRNA transcription, COX-2 protein expression and PGE(2) synthesis induced by DCA in HT-29 cell line. These data provide new insights into the mechanism of its anti-cancer properties.

Publication: Zhonghua Nei Ke Za Zhi 2009 Sep ;48(9)::760-3.
Publication Date: 2009 Sep
Study Author(s): Wang, Bang-mao;Zhai, Chun-ying;Fang, Wei-li;Chen, Xin;Jiang, Kui;Wang, Yu-ming;
Institution: Department of Gastroenterology, General Hospital, Tianjin Medical University, Tianjin 300052, China. [email protected]
Shortcut link to this study:
OBJECTIVE : To assess the effect of curcumin on deoxycholic acid (DCA) induced cell proliferation in human HT-29 colon cancer cell line and to discuss its underlying anti-cancer mechanisms.

METHODS : The effect of curcumin on cell proliferation was tested in vitro with MTT assay. RT-PCR was applied to measure cyclooxygenase-2 (COX-2) mRNA transcription. Cellular immunochemical stain was applied to label COX-2 protein expression. Radio immunoassay was applied to assess prostaglandin E(2) (PGE(2)) level.

RESULTS : DCA increased cell proliferation, COX-2 mRNA expression and PGE(2) concentration of HT-29 cell line. Curcumin inhibited DCA-induced cell proliferation of HT-29 cell in a dose and time depended manner. Curcumin may inhibit DCA-induced COX-2 mRNA transcription at 6 hour with more than 5 micromol/L and at 12 hour with more than 0.5 micromol/L. However, Curcumin may decrease DCA-induced COX-2 expression and PGE(2) synthesis at 24 - 48 hour with more than 1 micromol/L and at 6-12 hour with more than 5 micromol/L.

CONCLUSIONS : Curcumin may inhibit HT-29 cell proliferation, COX-2 mRNA transcription, COX-2 protein expression and PGE(2) synthesis induced by DCA in HT-29 cell line. These data provide new insights into the mechanism of its anti-cancer properties.
PMID: 20079215

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