|
|
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result sql = Anti-cancer drugs interfere with intracellular calcium signaling.
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result sql = (Neuro-)toxicity of metal and metal compounds is frequently highlighted. While specific metals or metal compounds are essential for cellular function, other metals are toxic and/or carcinogens. Metals can trigger accidental cell death in the form of necrosis, or activate programmed cell death in the form of apoptosis. The aim of anti-cancer therapy is induction of apoptosis in tumor cells. Therefore, there is an interesting twist in the toxicity of metals and metal compounds (e.g., arsenic trioxide, cisplatin); since they have a higher specificity to induce apoptosis in cancer cells (possibly due to the high turnover in these cells) they are used to cure some forms of cancer. A body of evidence suggests that second messengers, such as modulations in the intracellular calcium concentration, could be involved in metals induced toxicity as well as in the beneficial effects shown by anti-cancer drugs. HERE WE REVIEW THE INFLUENCE ON CALCIUM HOMEOSTASIS INDUCED BY SOME METALLIC COMPOUNDS: cisplatin, arsenic trioxide and trimethyltin chloride.
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result sql = Anti-cancer drugs interfere with intracellular calcium signaling.
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result sql = (Neuro-)toxicity of metal and metal compounds is frequently highlighted. While specific metals or metal compounds are essential for cellular function, other metals are toxic and/or carcinogens. Metals can trigger accidental cell death in the form of necrosis, or activate programmed cell death in the form of apoptosis. The aim of anti-cancer therapy is induction of apoptosis in tumor cells. Therefore, there is an interesting twist in the toxicity of metals and metal compounds (e.g., arsenic trioxide, cisplatin); since they have a higher specificity to induce apoptosis in cancer cells (possibly due to the high turnover in these cells) they are used to cure some forms of cancer. A body of evidence suggests that second messengers, such as modulations in the intracellular calcium concentration, could be involved in metals induced toxicity as well as in the beneficial effects shown by anti-cancer drugs. HERE WE REVIEW THE INFLUENCE ON CALCIUM HOMEOSTASIS INDUCED BY SOME METALLIC COMPOUNDS: cisplatin, arsenic trioxide and trimethyltin chloride.
Publication: Neurotoxicology 2009 Sep ;30(5)::803-10. :doi: 10.1016/j.neuro.2009.04.014.
Publication Date: 2009 Sep
Study Author(s): Florea, Ana-Maria;Büsselberg, Dietrich;
Institution: Institut für Physiologie, Universitätsklinikum Essen, Universität Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Shortcut link to this study:
Publication Date: 2009 Sep
Study Author(s): Florea, Ana-Maria;Büsselberg, Dietrich;
Institution: Institut für Physiologie, Universitätsklinikum Essen, Universität Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Shortcut link to this study:
(Neuro-)toxicity of metal and metal compounds is frequently highlighted. While specific metals or metal compounds are essential for cellular function, other metals are toxic and/or carcinogens. Metals can trigger accidental cell death in the form of necrosis, or activate programmed cell death in the form of apoptosis. The aim of anti-cancer therapy is induction of apoptosis in tumor cells. Therefore, there is an interesting twist in the toxicity of metals and metal compounds (e.g., arsenic trioxide, cisplatin); since they have a higher specificity to induce apoptosis in cancer cells (possibly due to the high turnover in these cells) they are used to cure some forms of cancer. A body of evidence suggests that second messengers, such as modulations in the intracellular calcium concentration, could be involved in metals induced toxicity as well as in the beneficial effects shown by anti-cancer drugs. HERE WE REVIEW THE INFLUENCE ON CALCIUM HOMEOSTASIS INDUCED BY SOME METALLIC COMPOUNDS: cisplatin, arsenic trioxide and trimethyltin chloride.
PMID: 19465052
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