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result sql = Modeling the interaction of binary and ternary mixtures of estradiol with bisphenol A and bisphenol AF in an in vitro estrogen-mediated transcriptional activation assay (T47D-KBluc).
Modeling the interaction of binary and ternary mixtures of estradiol with bisphenol A and bisphenol AF in an in vitro estrogen-mediated transcriptional activation assay (T47D-KBluc).
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char = t;code = 116
char = h;code = 104
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char = P;code = 80
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char = ;code = 32
char = a;code = 97
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char = .;code = 46
char = ;code = 32
char = L;code = 76
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char = C;code = 67
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char = h;code = 104
char = i;code = 105
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = l;code = 108
char = o;code = 111
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char = a;code = 97
char = l;code = 108
char = u;code = 117
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char = w;code = 119
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char = t;code = 116
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char = ;code = 32
char = S;code = 83
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char = s;code = 115
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char = ;code = 32
char = r;code = 114
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char = s;code = 115
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char = e;code = 101
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char = y;code = 121
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char = o;code = 111
char = r;code = 114
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char = i;code = 105
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char = d;code = 100
char = i;code = 105
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char = d;code = 100
char = u;code = 117
char = a;code = 97
char = l;code = 108
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char = m;code = 109
char = p;code = 112
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char = d;code = 100
char = s;code = 115
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char = w;code = 119
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char = e;code = 101
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char = a;code = 97
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char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = s;code = 115
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char = 2;code = 50
char = );code = 41
char = ,;code = 44
char = ;code = 32
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char = 1;code = 49
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char = .;code = 46
char = 1;code = 49
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char = +;code = 43
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char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 6;code = 54
char = 0;code = 48
char = 7;code = 55
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char = ,;code = 44
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 7;code = 55
char = 7;code = 55
char = 0;code = 48
char = 2;code = 50
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char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 1;code = 49
char = 7;code = 55
char = 3;code = 51
char = 9;code = 57
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char = ;code = 32
char = B;code = 66
char = P;code = 80
char = A;code = 65
char = ,;code = 44
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char = -;code = 45
char = 6;code = 54
char = .;code = 46
char = 6;code = 54
char = 7;code = 55
char = 9;code = 57
char = M;code = 77
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char = +;code = 43
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char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 8;code = 56
char = 5;code = 53
char = 0;code = 48
char = 5;code = 53
char = ,;code = 44
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 1;code = 49
char = 9;code = 57
char = 4;code = 52
char = ;code = 32
char = +;code = 43
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char = -;code = 45
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 2;code = 50
char = 1;code = 49
char = 3;code = 51
char = 7;code = 55
char = ;;code = 59
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = B;code = 66
char = P;code = 80
char = A;code = 65
char = F;code = 70
char = ,;code = 44
char = ;code = 32
char = -;code = 45
char = 7;code = 55
char = .;code = 46
char = 6;code = 54
char = 4;code = 52
char = 8;code = 56
char = M;code = 77
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 5;code = 53
char = 5;code = 53
char = 2;code = 50
char = 7;code = 55
char = ,;code = 44
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 2;code = 50
char = 7;code = 55
char = 3;code = 51
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 1;code = 49
char = 7;code = 55
char = 3;code = 51
char = 9;code = 57
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = T;code = 84
char = B;code = 66
char = B;code = 66
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = n;code = 110
char = o;code = 111
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char = ;code = 32
char = e;code = 101
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char = a;code = 97
char = l;code = 108
char = u;code = 117
char = a;code = 97
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char = d;code = 100
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char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = e;code = 101
char = c;code = 99
char = a;code = 97
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char = s;code = 115
char = e;code = 101
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char = f;code = 102
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = m;code = 109
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char = n;code = 110
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char = l;code = 108
char = y;code = 121
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char = s;code = 115
char = t;code = 116
char = r;code = 114
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char = g;code = 103
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char = i;code = 105
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char = s;code = 115
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char = o;code = 111
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char = s;code = 115
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char = a;code = 97
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char = ;code = 32
char = 3;code = 51
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char = x;code = 120
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 5;code = 53
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char = M;code = 77
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char = o;code = 111
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char = c;code = 99
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char = t;code = 116
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char = ;code = 32
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char = h;code = 104
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char = B;code = 66
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char = 2;code = 50
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char = ;code = 32
char = w;code = 119
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char = t;code = 116
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char = P;code = 80
char = A;code = 65
char = ;code = 32
char = a;code = 97
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char = B;code = 66
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char = A;code = 65
char = F;code = 70
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char = E;code = 69
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char = ,;code = 44
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char = B;code = 66
char = P;code = 80
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char = ,;code = 44
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char = F;code = 70
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char = a;code = 97
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char = .;code = 46
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char = F;code = 70
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char = r;code = 114
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char = b;code = 98
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char = a;code = 97
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char = s;code = 115
char = ,;code = 44
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char = a;code = 97
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char = ;code = 32
char = E;code = 69
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char = c;code = 99
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char = o;code = 111
char = f;code = 102
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char = B;code = 66
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = a;code = 97
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char = B;code = 66
char = P;code = 80
char = A;code = 65
char = F;code = 70
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char = P;code = 80
char = A;code = 65
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char = ;code = 32
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char = i;code = 105
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char = i;code = 105
char = d;code = 100
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char = l;code = 108
char = l;code = 108
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char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = x;code = 120
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
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char = >;code = 62
result sql = Exposure to xenoestrogens occurs against a backdrop to physiological levels of endogenous estrogens. Endogenous estrogen levels vary from low levels in early childhood to high levels during pregnancy and in young women. However, few studies have addressed how xenoestrogens interact with endogenous estrogens. The current study was designed to characterize the individual dose-response curves of estradiol-17beta (E(2)), bisphenol A (BPA), tetrabromo-bisphenol A (TBBPA), and bisphenol AF (BPAF, 4,4'-hexafluoroisopropylidene diphenol) on estrogen-dependent luciferase expression in T47D-KBluc cells and to determine how binary (8 x 8 factorial) and ternary (4 x 4 x 4 factorial) mixtures of an endogenous estrogen (E(2)) interact with BPA and/or BPAF. Log EC(50) and hillslope values with SEs, respectively, for individual compounds were as follows: E(2), -12.10M +/- 0.06071, 0.7702 +/- 0.1739; BPA, -6.679M +/- 0.08505, 1.194 +/- 0.2137; and BPAF, -7.648M +/- 0.05527, 1.273 +/- 0.1739 TBBPA : was not evaluated in mixture studies because of its minimally estrogenic response at 3 x10(-5)M and elicited cytotoxicity at higher concentrations. Both the binary mixtures of E(2) with BPA and BPAF and the ternary mixture of E(2), BPA, and BPAF behaved in an additive manner. For binary mixtures, as E(2) concentration increased, higher concentrations of BPA and BPAF were necessary to induce a significant increase in the estrogenic response. Understanding the behavior of mixture interactions of xenoestrogens, like BPA and BPAF, with endogenous estrogens will allow a better assessment of the potential risk associated with exposure to these chemicals, individually or as mixtures.

Publication: Toxicol. Sci. 2010 Aug ;116(2)::477-87. :doi: 10.1093/toxsci/kfq156.
Publication Date: 2010 Aug
Study Author(s): Bermudez, Dieldrich S;Gray, Leon E;Wilson, Vickie S;
Institution: Department of Molecular Biomedical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.
Shortcut link to this study:
Exposure to xenoestrogens occurs against a backdrop to physiological levels of endogenous estrogens. Endogenous estrogen levels vary from low levels in early childhood to high levels during pregnancy and in young women. However, few studies have addressed how xenoestrogens interact with endogenous estrogens. The current study was designed to characterize the individual dose-response curves of estradiol-17beta (E(2)), bisphenol A (BPA), tetrabromo-bisphenol A (TBBPA), and bisphenol AF (BPAF, 4,4'-hexafluoroisopropylidene diphenol) on estrogen-dependent luciferase expression in T47D-KBluc cells and to determine how binary (8 x 8 factorial) and ternary (4 x 4 x 4 factorial) mixtures of an endogenous estrogen (E(2)) interact with BPA and/or BPAF. Log EC(50) and hillslope values with SEs, respectively, for individual compounds were as follows: E(2), -12.10M +/- 0.06071, 0.7702 +/- 0.1739; BPA, -6.679M +/- 0.08505, 1.194 +/- 0.2137; and BPAF, -7.648M +/- 0.05527, 1.273 +/- 0.1739 TBBPA : was not evaluated in mixture studies because of its minimally estrogenic response at 3 x10(-5)M and elicited cytotoxicity at higher concentrations. Both the binary mixtures of E(2) with BPA and BPAF and the ternary mixture of E(2), BPA, and BPAF behaved in an additive manner. For binary mixtures, as E(2) concentration increased, higher concentrations of BPA and BPAF were necessary to induce a significant increase in the estrogenic response. Understanding the behavior of mixture interactions of xenoestrogens, like BPA and BPAF, with endogenous estrogens will allow a better assessment of the potential risk associated with exposure to these chemicals, individually or as mixtures.
PMID: 20498000

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