char = E;code = 69 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = M;code = 77 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = D;code = 68 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = H;code = 72 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = t;code = 116 char = ;code = 32 char = F;code = 70 char = a;code = 97 char = i;code = 105 char = l;code = 108 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = T;code = 84 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = S;code = 83 char = t;code = 116 char = a;code = 97 char = r;code = 114 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = B;code = 66 char = i;code = 105 char = s;code = 115 char = o;code = 111 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = F;code = 70 char = o;code = 111 char = l;code = 108 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = E;code = 69 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = a;code = 97 char = p;code = 112 char = r;code = 114 char = i;code = 105 char = l;code = 108 char = ,;code = 44 char = ;code = 32 char = C;code = 67 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = O;code = 79 char = p;code = 112 char = p;code = 112 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = O;code = 79 char = r;code = 114 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = :;code = 58 char = ;code = 32 char = R;code = 82 char = e;code = 101 char = s;code = 115 char = u;code = 117 char = l;code = 108 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = R;code = 82 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = o;code = 111 char = m;code = 109 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = C;code = 67 char = I;code = 73 char = B;code = 66 char = I;code = 73 char = S;code = 83 char = ;code = 32 char = I;code = 73 char = I;code = 73 char = I;code = 73 char = ;code = 32 char = T;code = 84 char = r;code = 114 char = i;code = 105 char = a;code = 97 char = l;code = 108 char = .;code = 46 result sql = Effect on Mode of Death of Heart Failure Treatment Started with Bisoprolol Followed by Enalapril, Compared to the Opposite Order: Results of the Randomized CIBIS III Trial.
Effect on Mode of Death of Heart Failure Treatment Started with Bisoprolol Followed by Enalapril, Compared to the Opposite Order: Results of the Randomized CIBIS III Trial.char = <;code = 60 char = b;code = 98 char = >;code = 62 char = B;code = 66 char = A;code = 65 char = C;code = 67 char = K;code = 75 char = G;code = 71 char = R;code = 82 char = O;code = 79 char = U;code = 85 char = N;code = 78 char = D;code = 68 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = ;code = 32 char = M;code = 77 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = h;code = 104 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = t;code = 116 char = ;code = 32 char = f;code = 102 char = a;code = 97 char = i;code = 105 char = l;code = 108 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = C;code = 67 char = H;code = 72 char = F;code = 70 char = );code = 41 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = e;code = 101 char = v;code = 118 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = o;code = 111 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = p;code = 112 char = y;code = 121 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = .;code = 46 char = ;code = 32 char = S;code = 83 char = u;code = 117 char = d;code = 100 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = r;code = 114 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = /;code = 47 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = l;code = 108 char = d;code = 100 char = /;code = 47 char = m;code = 109 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = C;code = 67 char = H;code = 72 char = F;code = 70 char = .;code = 46 char = ;code = 32 char = &;code = 38 char = #;code = 35 char = 9;code = 57 char = 4;code = 52 char = 6;code = 54 char = ;;code = 59 char = -;code = 45 char = B;code = 66 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = k;code = 107 char = a;code = 97 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = v;code = 118 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = g;code = 103 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = d;code = 100 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = A;code = 65 char = C;code = 67 char = E;code = 69 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = h;code = 104 char = i;code = 105 char = b;code = 98 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = (;code = 40 char = A;code = 65 char = C;code = 67 char = E;code = 69 char = I;code = 73 char = );code = 41 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = t;code = 116 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = .;code = 46 char = ;code = 32 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = M;code = 77 char = E;code = 69 char = T;code = 84 char = H;code = 72 char = O;code = 79 char = D;code = 68 char = S;code = 83 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = ;code = 32 char = W;code = 87 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = o;code = 111 char = m;code = 109 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = 1;code = 49 char = 0;code = 48 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = l;code = 108 char = d;code = 100 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = b;code = 98 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = C;code = 67 char = H;code = 72 char = F;code = 70 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = l;code = 108 char = e;code = 101 char = f;code = 102 char = t;code = 116 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = e;code = 101 char = j;code = 106 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = &;code = 38 char = #;code = 35 char = 8;code = 56 char = 8;code = 56 char = 0;code = 48 char = 4;code = 52 char = ;;code = 59 char = 3;code = 51 char = 5;code = 53 char = %;code = 37 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = o;code = 111 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = A;code = 65 char = C;code = 67 char = E;code = 69 char = I;code = 73 char = ,;code = 44 char = ;code = 32 char = &;code = 38 char = #;code = 35 char = 9;code = 57 char = 4;code = 52 char = 6;code = 54 char = ;;code = 59 char = -;code = 45 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = k;code = 107 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = g;code = 103 char = i;code = 105 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = -;code = 45 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = p;code = 112 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = -;code = 45 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = k;code = 107 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = p;code = 112 char = y;code = 121 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = e;code = 101 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = b;code = 98 char = i;code = 105 char = s;code = 115 char = o;code = 111 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 5;code = 53 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = a;code = 97 char = p;code = 112 char = r;code = 114 char = i;code = 105 char = l;code = 108 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 5;code = 53 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = 6;code = 54 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = l;code = 108 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = i;code = 105 char = r;code = 114 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = b;code = 98 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = 6;code = 54 char = -;code = 45 char = 2;code = 50 char = 4;code = 52 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = w;code = 119 char = o;code = 111 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = g;code = 103 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = g;code = 103 char = a;code = 97 char = r;code = 114 char = d;code = 100 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = j;code = 106 char = u;code = 117 char = d;code = 100 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = ,;code = 44 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = c;code = 99 char = l;code = 108 char = u;code = 117 char = d;code = 100 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = d;code = 100 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = g;code = 103 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = u;code = 117 char = m;code = 109 char = p;code = 112 char = ;code = 32 char = f;code = 102 char = a;code = 97 char = i;code = 105 char = l;code = 108 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = .;code = 46 char = ;code = 32 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = R;code = 82 char = E;code = 69 char = S;code = 83 char = U;code = 85 char = L;code = 76 char = T;code = 84 char = S;code = 83 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = ;code = 32 char = D;code = 68 char = u;code = 117 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = p;code = 112 char = y;code = 121 char = ;code = 32 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = s;code = 115 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = 8;code = 56 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 2;code = 50 char = 3;code = 51 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = i;code = 105 char = s;code = 115 char = o;code = 111 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = o;code = 111 char = l;code = 108 char = -;code = 45 char = f;code = 102 char = i;code = 105 char = r;code = 114 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = d;code = 100 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = ,;code = 44 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 1;code = 49 char = 6;code = 54 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 3;code = 51 char = 2;code = 50 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = a;code = 97 char = p;code = 112 char = r;code = 114 char = i;code = 105 char = l;code = 108 char = -;code = 45 char = f;code = 102 char = i;code = 105 char = r;code = 114 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = :;code = 58 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = z;code = 122 char = a;code = 97 char = r;code = 114 char = d;code = 100 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = ;code = 32 char = (;code = 40 char = H;code = 72 char = R;code = 82 char = );code = 41 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = d;code = 100 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 5;code = 53 char = 0;code = 48 char = ;;code = 59 char = ;code = 32 char = 9;code = 57 char = 5;code = 53 char = %;code = 37 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = f;code = 102 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = (;code = 40 char = C;code = 67 char = I;code = 73 char = );code = 41 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 2;code = 50 char = 1;code = 49 char = -;code = 45 char = 1;code = 49 char = .;code = 46 char = 1;code = 49 char = 6;code = 54 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = =;code = 61 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 1;code = 49 char = 0;code = 48 char = 7;code = 55 char = .;code = 46 char = ;code = 32 char = A;code = 65 char = t;code = 116 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = y;code = 121 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = 6;code = 54 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 4;code = 52 char = 2;code = 50 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = 2;code = 50 char = 9;code = 57 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 6;code = 54 char = 0;code = 48 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = d;code = 100 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = :;code = 58 char = ;code = 32 char = H;code = 72 char = R;code = 82 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 5;code = 53 char = 4;code = 52 char = ;;code = 59 char = ;code = 32 char = 9;code = 57 char = 5;code = 53 char = %;code = 37 char = ;code = 32 char = C;code = 67 char = I;code = 73 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 2;code = 50 char = 9;code = 57 char = -;code = 45 char = 1;code = 49 char = .;code = 46 char = 0;code = 48 char = 0;code = 48 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = =;code = 61 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 4;code = 52 char = 9;code = 57 char = .;code = 46 char = ;code = 32 char = A;code = 65 char = t;code = 116 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = y;code = 121 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = d;code = 100 char = ,;code = 44 char = ;code = 32 char = 2;code = 50 char = 9;code = 57 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 6;code = 54 char = 5;code = 53 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = 3;code = 51 char = 4;code = 52 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 7;code = 55 char = 3;code = 51 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = d;code = 100 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = :;code = 58 char = ;code = 32 char = H;code = 72 char = R;code = 82 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 8;code = 56 char = 4;code = 52 char = ;;code = 59 char = ;code = 32 char = 9;code = 57 char = 5;code = 53 char = %;code = 37 char = ;code = 32 char = C;code = 67 char = I;code = 73 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 5;code = 53 char = 1;code = 49 char = -;code = 45 char = 1;code = 49 char = .;code = 46 char = 3;code = 51 char = 8;code = 56 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = =;code = 61 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 4;code = 52 char = 8;code = 56 char = 7;code = 55 char = .;code = 46 char = ;code = 32 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = C;code = 67 char = O;code = 79 char = M;code = 77 char = P;code = 80 char = A;code = 65 char = R;code = 82 char = A;code = 65 char = B;code = 66 char = L;code = 76 char = E;code = 69 char = ;code = 32 char = F;code = 70 char = I;code = 73 char = G;code = 71 char = U;code = 85 char = R;code = 82 char = E;code = 69 char = S;code = 83 char = ;code = 32 char = F;code = 70 char = O;code = 79 char = R;code = 82 char = ;code = 32 char = P;code = 80 char = U;code = 85 char = M;code = 77 char = P;code = 80 char = ;code = 32 char = F;code = 70 char = A;code = 65 char = I;code = 73 char = L;code = 76 char = U;code = 85 char = R;code = 82 char = E;code = 69 char = ;code = 32 char = D;code = 68 char = E;code = 69 char = A;code = 65 char = T;code = 84 char = H;code = 72 char = ;code = 32 char = W;code = 87 char = E;code = 69 char = R;code = 82 char = E;code = 69 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = p;code = 112 char = y;code = 121 char = ,;code = 44 char = ;code = 32 char = 7;code = 55 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 2;code = 50 char = 3;code = 51 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = 2;code = 50 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 3;code = 51 char = 2;code = 50 char = :;code = 58 char = ;code = 32 char = H;code = 72 char = R;code = 82 char = ;code = 32 char = 3;code = 51 char = .;code = 46 char = 4;code = 52 char = 3;code = 51 char = ;;code = 59 char = ;code = 32 char = 9;code = 57 char = 5;code = 53 char = %;code = 37 char = ;code = 32 char = C;code = 67 char = I;code = 73 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 7;code = 55 char = 1;code = 49 char = -;code = 45 char = 1;code = 49 char = 6;code = 54 char = .;code = 46 char = 5;code = 53 char = 3;code = 51 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = =;code = 61 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 1;code = 49 char = 2;code = 50 char = 4;code = 52 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = y;code = 121 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = 3;code = 51 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 4;code = 52 char = 2;code = 50 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = 5;code = 53 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 6;code = 54 char = 0;code = 48 char = :;code = 58 char = ;code = 32 char = H;code = 72 char = R;code = 82 char = ;code = 32 char = 2;code = 50 char = .;code = 46 char = 5;code = 53 char = 7;code = 55 char = ;;code = 59 char = ;code = 32 char = 9;code = 57 char = 5;code = 53 char = %;code = 37 char = ;code = 32 char = C;code = 67 char = I;code = 73 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 9;code = 57 char = 2;code = 50 char = -;code = 45 char = 7;code = 55 char = .;code = 46 char = 2;code = 50 char = 0;code = 48 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = =;code = 61 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 7;code = 55 char = 3;code = 51 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = y;code = 121 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = d;code = 100 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = 7;code = 55 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 6;code = 54 char = 5;code = 53 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = 7;code = 55 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 7;code = 55 char = 3;code = 51 char = :;code = 58 char = ;code = 32 char = H;code = 72 char = R;code = 82 char = ;code = 32 char = 2;code = 50 char = .;code = 46 char = 3;code = 51 char = 9;code = 57 char = ;;code = 59 char = ;code = 32 char = 9;code = 57 char = 5;code = 53 char = %;code = 37 char = ;code = 32 char = C;code = 67 char = I;code = 73 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 9;code = 57 char = 9;code = 57 char = -;code = 45 char = 5;code = 53 char = .;code = 46 char = 7;code = 55 char = 5;code = 53 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = =;code = 61 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = 3;code = 51 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = -;code = 45 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = f;code = 102 char = a;code = 97 char = t;code = 116 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = C;code = 67 char = O;code = 79 char = N;code = 78 char = C;code = 67 char = L;code = 76 char = U;code = 85 char = S;code = 83 char = I;code = 73 char = O;code = 79 char = N;code = 78 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = p;code = 112 char = y;code = 121 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = b;code = 98 char = i;code = 105 char = s;code = 115 char = o;code = 111 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = a;code = 97 char = p;code = 112 char = r;code = 114 char = i;code = 105 char = l;code = 108 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = i;code = 105 char = s;code = 115 char = k;code = 107 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = d;code = 100 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = d;code = 100 char = u;code = 117 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = f;code = 102 char = i;code = 105 char = r;code = 114 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = y;code = 121 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = l;code = 108 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = y;code = 121 char = s;code = 115 char = t;code = 116 char = o;code = 111 char = l;code = 108 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = C;code = 67 char = H;code = 72 char = F;code = 70 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = h;code = 104 char = o;code = 111 char = r;code = 114 char = t;code = 116 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = o;code = 111 char = m;code = 109 char = e;code = 101 char = w;code = 119 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = f;code = 102 char = s;code = 115 char = e;code = 101 char = t;code = 116 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = u;code = 117 char = m;code = 109 char = p;code = 112 char = ;code = 32 char = f;code = 102 char = a;code = 97 char = i;code = 105 char = l;code = 108 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = h;code = 104 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = i;code = 105 char = s;code = 115 char = o;code = 111 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = o;code = 111 char = l;code = 108 char = -;code = 45 char = f;code = 102 char = i;code = 105 char = r;code = 114 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = h;code = 104 char = o;code = 111 char = r;code = 114 char = t;code = 116 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 result sql = BACKGROUND: Mode of death in chronic heart failure (CHF) may be of relevance to choice of therapy for this condition. Sudden death is particularly common in patients with early and/or mild/moderate CHF. β-Blockade may provide better protection against sudden death than ACE inhibition (ACEI) in this setting. METHODS: We randomized 1010 patients with mild or moderate, stable CHF and left ventricular ejection fraction ≤35%, without ACEI, β-blocker or angiotensin-receptor-blocker therapy, to either bisoprolol (n = 505) or enalapril (n = 505) for 6 months, followed by their combination for 6-24 months. The two strategies were blindly compared regarding adjudicated mode of death, including sudden death and progressive pump failure death. RESULTS: During the monotherapy phase, 8 of 23 deaths in the bisoprolol-first group were sudden, compared to 16 of 32 in the enalapril-first group: hazard ratio (HR) for sudden death 0.50; 95% confidence interval (CI) 0.21-1.16; P= 0.107. At 1 year, 16 of 42 versus 29 of 60 deaths were sudden: HR 0.54; 95% CI 0.29-1.00; P= 0.049. At study end, 29 of 65 versus 34 of 73 deaths were sudden: HR 0.84; 95% CI 0.51-1.38; P= 0.487. COMPARABLE FIGURES FOR PUMP FAILURE DEATH WERE: monotherapy, 7 of 23 deaths versus 2 of 32: HR 3.43; 95% CI 0.71-16.53; P= 0.124, at 1 year, 13 of 42 versus 5 of 60: HR 2.57; 95% CI 0.92-7.20; P= 0.073, at study end, 17 of 65 versus 7 of 73: HR 2.39; 95% CI 0.99-5.75; P= 0.053. There were no significant between-group differences in any other fatal events. CONCLUSION: Initiating therapy with bisoprolol compared to enalapril decreased the risk of sudden death during the first year in this mild systolic CHF cohort. This was somewhat offset by an increase in pump failure deaths in the bisoprolol-first cohort.
Publication: Cardiovasc Ther 2010 Jun 1 ;:. :doi: 10.1111/j.1755-5922.2010.00185.x.
Publication Date: 2010 Jun 1
Study Author(s): Krum, Henry;Van Veldhuisen, Dirk J;Funck-Brentano, Christian;Vanoli, Emilio;Silke, Bernard;Erdmann, Erland;Follath, Ferenc;Ponikowski, Piotr;Goulder, Michael;Meyer, Wilfried;Lechat, Philippe;Willenheimer, Ronnie;on behalf of the CIBIS III Investigators;
Institution: Departments of Epidemiology and Preventive Medicine and Medicine, Monash University, Alfred Hospital, Melbourne, Australia Thoraxcenter, Department of Cardiology, University Hospital Groningen, The Netherlands UPMC - AP-HP - INSERM CIC9304, Department of Pharmacology, Pitié-Salpêtrière Hospital, Paris, France Department of Cardiology, University of Pavia and Policlinico di Monza, Italy Department of Pharmacology & Therapeutics, Trinity Centre, St James' Hospital, Dublin, Ireland Medizinische Klinik III, University of Cologne, Germany Medicine A, University Hospital Zürich, Switzerland Department of Heart Diseases, Medical University, Wroclaw, Poland Worldwide Clinical Trials, Nottingham, UK Merck KGaA, Darmstadt, Germany Service de Pharmacologie, Hopital Pitié-Salpetriere, Paris, France Lund University and Heart Health Group, Malmö, Sweden.
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BACKGROUND: Mode of death in chronic heart failure (CHF) may be of relevance to choice of therapy for this condition. Sudden death is particularly common in patients with early and/or mild/moderate CHF. β-Blockade may provide better protection against sudden death than ACE inhibition (ACEI) in this setting. METHODS: We randomized 1010 patients with mild or moderate, stable CHF and left ventricular ejection fraction ≤35%, without ACEI, β-blocker or angiotensin-receptor-blocker therapy, to either bisoprolol (n = 505) or enalapril (n = 505) for 6 months, followed by their combination for 6-24 months. The two strategies were blindly compared regarding adjudicated mode of death, including sudden death and progressive pump failure death. RESULTS: During the monotherapy phase, 8 of 23 deaths in the bisoprolol-first group were sudden, compared to 16 of 32 in the enalapril-first group: hazard ratio (HR) for sudden death 0.50; 95% confidence interval (CI) 0.21-1.16; P= 0.107. At 1 year, 16 of 42 versus 29 of 60 deaths were sudden: HR 0.54; 95% CI 0.29-1.00; P= 0.049. At study end, 29 of 65 versus 34 of 73 deaths were sudden: HR 0.84; 95% CI 0.51-1.38; P= 0.487. COMPARABLE FIGURES FOR PUMP FAILURE DEATH WERE: monotherapy, 7 of 23 deaths versus 2 of 32: HR 3.43; 95% CI 0.71-16.53; P= 0.124, at 1 year, 13 of 42 versus 5 of 60: HR 2.57; 95% CI 0.92-7.20; P= 0.073, at study end, 17 of 65 versus 7 of 73: HR 2.39; 95% CI 0.99-5.75; P= 0.053. There were no significant between-group differences in any other fatal events. CONCLUSION: Initiating therapy with bisoprolol compared to enalapril decreased the risk of sudden death during the first year in this mild systolic CHF cohort. This was somewhat offset by an increase in pump failure deaths in the bisoprolol-first cohort.
PMID: 20528880