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result sql = Anti-angiogenic therapy: adapting strategies to overcome resistant tumors.
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result sql = Healthy cells, as well as benign and malignant tumors, depend upon the body's blood supply to bring in oxygen and nutrients and carry away waste products. Using this property against tumors, anti-angiogenic therapy targets the tumor vasculature with the aim of starving the tumor, and has demonstrated exceptional clinical efficacy against a number of tumors. This review discusses the current state of knowledge regarding anti-angiogenic therapies presently available to patients, and garners from both preclinical and clinical literature the benefits and side effects associated with anti-angiogenic therapies, the unfortunate mechanisms of acquired resistance to these novel therapeutics, and highlights promising next generation anti-angiogenics that may overcome the limitations encountered with first generation therapies.
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result sql = Anti-angiogenic therapy: adapting strategies to overcome resistant tumors.
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char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Healthy cells, as well as benign and malignant tumors, depend upon the body's blood supply to bring in oxygen and nutrients and carry away waste products. Using this property against tumors, anti-angiogenic therapy targets the tumor vasculature with the aim of starving the tumor, and has demonstrated exceptional clinical efficacy against a number of tumors. This review discusses the current state of knowledge regarding anti-angiogenic therapies presently available to patients, and garners from both preclinical and clinical literature the benefits and side effects associated with anti-angiogenic therapies, the unfortunate mechanisms of acquired resistance to these novel therapeutics, and highlights promising next generation anti-angiogenics that may overcome the limitations encountered with first generation therapies.
Publication: J. Cell. Biochem. 2010 Oct 15 ;111(3)::543-53. :doi: 10.1002/jcb.22764.
Publication Date: 2010 Oct 15
Study Author(s): Mitchell, Dianne C;Bryan, Brad A;
Institution: Acceleron Pharmaceuticals, Cambridge, Massachusetts, USA.
Shortcut link to this study:
Publication Date: 2010 Oct 15
Study Author(s): Mitchell, Dianne C;Bryan, Brad A;
Institution: Acceleron Pharmaceuticals, Cambridge, Massachusetts, USA.
Shortcut link to this study:
Healthy cells, as well as benign and malignant tumors, depend upon the body's blood supply to bring in oxygen and nutrients and carry away waste products. Using this property against tumors, anti-angiogenic therapy targets the tumor vasculature with the aim of starving the tumor, and has demonstrated exceptional clinical efficacy against a number of tumors. This review discusses the current state of knowledge regarding anti-angiogenic therapies presently available to patients, and garners from both preclinical and clinical literature the benefits and side effects associated with anti-angiogenic therapies, the unfortunate mechanisms of acquired resistance to these novel therapeutics, and highlights promising next generation anti-angiogenics that may overcome the limitations encountered with first generation therapies.
PMID: 20626031
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