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result sql = The effect of ginkgo biloba on the rat retinal ganglion cell survival in the optic nerve crush model.
The effect of ginkgo biloba on the rat retinal ganglion cell survival in the optic nerve crush model.
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char = .;code = 46
char = 5;code = 53
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char = .;code = 46
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char = <;code = 60
char = b;code = 98
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char = /;code = 47
char = >;code = 62
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char = >;code = 62
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char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
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char = h;code = 104
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char = ;code = 32
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char = t;code = 116
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char = a;code = 97
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char = n;code = 110
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char = i;code = 105
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char = o;code = 111
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char = ;code = 32
char = a;code = 97
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char = k;code = 107
char = g;code = 103
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char = r;code = 114
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char = ;code = 32
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char = o;code = 111
char = r;code = 114
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char = y;code = 121
char = ;code = 32
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char = t;code = 116
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char = ;code = 32
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char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = n;code = 110
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char = p;code = 112
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char = n;code = 110
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char = e;code = 101
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char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
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char = ;code = 32
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char = g;code = 103
char = h;code = 104
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char = u;code = 117
char = r;code = 114
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = a;code = 97
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char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = e;code = 101
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = a;code = 97
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char = g;code = 103
char = l;code = 108
char = i;code = 105
char = o;code = 111
char = n;code = 110
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result sql = PURPOSE : To investigate the effect of ginkgo biloba on the retinal ganglion cell survival in a rat optic nerve crush model.

METHODS : Twenty-four Sprague-Dawley rats were divided randomly into a study group of 12 animals receiving intraperitoneal injections of ginkgo biloba and a control group of 12 animals receiving intraperitoneal saline injections. All injections were performed 1 hr before the optic nerve crush and daily afterwards. For each animal, the right optic nerve was crushed closely behind the globe for 60 seconds using a microclip with 40 g power. The left optic nerve was kept intact. At 23 days after the optic nerve crush, the retinal ganglion cells were labelled retrogradely by injecting 3% fluorogold into both sides of the superior colliculus of the brain. At 4 weeks after the optic nerve crush, the animals were killed. Photographs taken from retinal flat mounts were assessed for the number and density of the retinal ganglion cells.

RESULTS : The survival rate, defined as the ratio of the retinal ganglion cell density in the right eye with the optic nerve crush divided by the retinal ganglion cell density in left eye without an optic nerve trauma, was significantly (p=0.035) higher in the study group with ginkgo biloba than in the control group (60.0+/-6.0% versus 53.5+/-8.0%).

CONCLUSION : The results suggest that intraperitoneal injections of a ginkgo biloba extract given prior to and daily after an experimental and standardized optic nerve crush in rats were associated with a higher survival rate of retinal ganglion cells.

Publication: Acta Ophthalmol 2010 Aug ;88(5)::553-7. :doi: 10.1111/j.1755-3768.2008.01486.x.
Publication Date: 2010 Aug
Study Author(s): Ma, Ke;Xu, Liang;Zhang, Haijuan;Zhang, Shixian;Pu, Mingliang;Jonas, Jost B;
Institution: Beijing Institute of Ophthalmology, Beijing TongRen Eye Hospital, Capital Medical University, Beijing, China. [email protected]
Shortcut link to this study:
PURPOSE : To investigate the effect of ginkgo biloba on the retinal ganglion cell survival in a rat optic nerve crush model.

METHODS : Twenty-four Sprague-Dawley rats were divided randomly into a study group of 12 animals receiving intraperitoneal injections of ginkgo biloba and a control group of 12 animals receiving intraperitoneal saline injections. All injections were performed 1 hr before the optic nerve crush and daily afterwards. For each animal, the right optic nerve was crushed closely behind the globe for 60 seconds using a microclip with 40 g power. The left optic nerve was kept intact. At 23 days after the optic nerve crush, the retinal ganglion cells were labelled retrogradely by injecting 3% fluorogold into both sides of the superior colliculus of the brain. At 4 weeks after the optic nerve crush, the animals were killed. Photographs taken from retinal flat mounts were assessed for the number and density of the retinal ganglion cells.

RESULTS : The survival rate, defined as the ratio of the retinal ganglion cell density in the right eye with the optic nerve crush divided by the retinal ganglion cell density in left eye without an optic nerve trauma, was significantly (p=0.035) higher in the study group with ginkgo biloba than in the control group (60.0+/-6.0% versus 53.5+/-8.0%).

CONCLUSION : The results suggest that intraperitoneal injections of a ginkgo biloba extract given prior to and daily after an experimental and standardized optic nerve crush in rats were associated with a higher survival rate of retinal ganglion cells.
PMID: 19681765

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