|
|
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result sql = AKT and p21 WAF1/CIP1 as potential genistein targets in BRCA1-mutant human breast cancer cell lines.
AKT and p21 WAF1/CIP1 as potential genistein targets in BRCA1-mutant human breast cancer cell lines.char = B;code = 66
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char = P;code = 80
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char = ;code = 32
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char = t;code = 116
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result sql = BRCA1 acts as a tumour suppressor and germ-line mutations within this gene are found in a large proportion of families with breast cancer. The aim of our study was to unravel the mechanism of action of genistein, the major soy phytoestrogen, in BRCA1-mutant human breast cancer cell lines. Four breast cancer cell lines were studied for their response to genistein, three of them harbouring different mutations within the BRCA1 gene (HCC1937, SUM149 and SUM1315 cells) and the MDA-MB-231 cell line, which expresses a functional BRCA1 protein. We showed that genistein inhibits proliferation and induces apoptosis more efficiently in BRCA1-mutant cells than in cells expressing wild-type BRCA1 protein. Increased AKT and decreased p21(WAF1/CIP1) protein levels could explain the relative resistance to genistein elicited by cells with wild-type BRCA1. BRCA1-mutant breast cancer cells are highly sensitive to genistein treatment and p21(WAF1/CIP1) and AKT could be genistein targets in these cells.
char = K;code = 75
char = T;code = 84
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = 2;code = 50
char = 1;code = 49
char = ;code = 32
char = W;code = 87
char = A;code = 65
char = F;code = 70
char = 1;code = 49
char = /;code = 47
char = C;code = 67
char = I;code = 73
char = P;code = 80
char = 1;code = 49
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = B;code = 66
char = R;code = 82
char = C;code = 67
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char = -;code = 45
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char = t;code = 116
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = r;code = 114
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = .;code = 46
result sql = AKT and p21 WAF1/CIP1 as potential genistein targets in BRCA1-mutant human breast cancer cell lines.
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char = C;code = 67
char = A;code = 65
char = 1;code = 49
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char = t;code = 116
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = u;code = 117
char = r;code = 114
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char = u;code = 117
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char = p;code = 112
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char = s;code = 115
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char = B;code = 66
char = R;code = 82
char = C;code = 67
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char = l;code = 108
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result sql = BRCA1 acts as a tumour suppressor and germ-line mutations within this gene are found in a large proportion of families with breast cancer. The aim of our study was to unravel the mechanism of action of genistein, the major soy phytoestrogen, in BRCA1-mutant human breast cancer cell lines. Four breast cancer cell lines were studied for their response to genistein, three of them harbouring different mutations within the BRCA1 gene (HCC1937, SUM149 and SUM1315 cells) and the MDA-MB-231 cell line, which expresses a functional BRCA1 protein. We showed that genistein inhibits proliferation and induces apoptosis more efficiently in BRCA1-mutant cells than in cells expressing wild-type BRCA1 protein. Increased AKT and decreased p21(WAF1/CIP1) protein levels could explain the relative resistance to genistein elicited by cells with wild-type BRCA1. BRCA1-mutant breast cancer cells are highly sensitive to genistein treatment and p21(WAF1/CIP1) and AKT could be genistein targets in these cells.
Publication: Anticancer Res. 2010 Jun ;30(6)::2049-54.
Publication Date: 2010 Jun
Study Author(s): Privat, Maud;Aubel, Corinne;Arnould, Stephanie;Communal, Yves;Ferrara, Marc;Bignon, Yves-Jean;
Institution: Centre Jean Perrin, Département d'Oncogénétique, F-63000 Clermont-Ferrand, France.
Shortcut link to this study:
Publication Date: 2010 Jun
Study Author(s): Privat, Maud;Aubel, Corinne;Arnould, Stephanie;Communal, Yves;Ferrara, Marc;Bignon, Yves-Jean;
Institution: Centre Jean Perrin, Département d'Oncogénétique, F-63000 Clermont-Ferrand, France.
Shortcut link to this study:
BRCA1 acts as a tumour suppressor and germ-line mutations within this gene are found in a large proportion of families with breast cancer. The aim of our study was to unravel the mechanism of action of genistein, the major soy phytoestrogen, in BRCA1-mutant human breast cancer cell lines. Four breast cancer cell lines were studied for their response to genistein, three of them harbouring different mutations within the BRCA1 gene (HCC1937, SUM149 and SUM1315 cells) and the MDA-MB-231 cell line, which expresses a functional BRCA1 protein. We showed that genistein inhibits proliferation and induces apoptosis more efficiently in BRCA1-mutant cells than in cells expressing wild-type BRCA1 protein. Increased AKT and decreased p21(WAF1/CIP1) protein levels could explain the relative resistance to genistein elicited by cells with wild-type BRCA1. BRCA1-mutant breast cancer cells are highly sensitive to genistein treatment and p21(WAF1/CIP1) and AKT could be genistein targets in these cells.
PMID: 20651350
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